Chromatin lysine acylation: On the path to chromatin homeostasis and genome integrity
Feng Chen,
Xingkai He,
Wenchao Xu
et al.
Abstract:The fundamental role of cells in safeguarding the genome's integrity against DNA double‐strand breaks (DSBs) is crucial for maintaining chromatin homeostasis and the overall genomic stability. Aberrant responses to DNA damage, known as DNA damage responses (DDRs), can result in genomic instability and contribute significantly to tumorigenesis. Unraveling the intricate mechanisms underlying DDRs following severe damage holds the key to identify therapeutic targets for cancer. Chromatin lysine acylation, encompa… Show more
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