2015
DOI: 10.1186/s13059-015-0768-0
|View full text |Cite
|
Sign up to set email alerts
|

Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells

Abstract: BackgroundHigher-order chromatin structure is often perturbed in cancer and other pathological states. Although several genetic and epigenetic differences have been charted between normal and breast cancer tissues, changes in higher-order chromatin organization during tumorigenesis have not been fully explored. To probe the differences in higher-order chromatin structure between mammary epithelial and breast cancer cells, we performed Hi-C analysis on MCF-10A mammary epithelial and MCF-7 breast cancer cell lin… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

21
224
0
2

Year Published

2016
2016
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 204 publications
(247 citation statements)
references
References 74 publications
21
224
0
2
Order By: Relevance
“…S4A-J). The shSCRAM and shSMARCA4 Hi-C data sets exhibited high correlation (R 2 > 0.95) with the previously published wild-type MCF-10A Hi-C data set (Barutcu et al 2015). The scaling plot curves of genomic interaction frequencies along genomic distance showed similar trends of decay and an increase at distances larger than >200 Mb, which we previously showed to be a characteristic of the MCF-10A genome (Supplemental Fig.…”
Section: Hi-c Analysis Of Smarca4 Knockdown and Control Mcf-10a Cellssupporting
confidence: 53%
See 4 more Smart Citations
“…S4A-J). The shSCRAM and shSMARCA4 Hi-C data sets exhibited high correlation (R 2 > 0.95) with the previously published wild-type MCF-10A Hi-C data set (Barutcu et al 2015). The scaling plot curves of genomic interaction frequencies along genomic distance showed similar trends of decay and an increase at distances larger than >200 Mb, which we previously showed to be a characteristic of the MCF-10A genome (Supplemental Fig.…”
Section: Hi-c Analysis Of Smarca4 Knockdown and Control Mcf-10a Cellssupporting
confidence: 53%
“…Moreover, we identified large blocks of inter-chromosomal interactions between Chr 3 and Chr 5, Chr 3 and Chr 9, and Chr 6 and Chr 19, which represent previously known translocations in the MCF-10A genome (Supplemental Fig. S5; Marella et al 2009;Barutcu et al 2015). Taken together, these analyses reflect the high quality and reproducibility of the Hi-C data.…”
Section: Hi-c Analysis Of Smarca4 Knockdown and Control Mcf-10a Cellssupporting
confidence: 52%
See 3 more Smart Citations