Chromatin complexes as aperiodic microcrystalline arrays that regulate genome organisation and expression

Singh, Prim B.; Huskisson, Neville S.

doi:10.1002/(sici)1520-6408(1998)22:1<85::aid-dvg9>3.0.co;2-3

Cited by 24 publications

(10 citation statements)

References 71 publications

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“…Smith and Benavente 1995). Such chromatin structures have repeatedly, been compared with crystals (for example , Hennig 1982;Singh and Huskinsson 1998). The compaction may be caused or enhanced by a regular arrangement of silencing protein complexes or on regularly positioned nucleosomes, most likely in combination with modified histones.…”

Section: Heterochromatin As a State Of Chromatinmentioning

confidence: 99%

Heterochromatin

Hennig¹

1999

Chromosoma

127

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The properties of heterochromatin are reconsidered in the context of our present understanding of gene silencing, telomeric and centromeric properties, position-effect variegation and X-chromosome inactivation. It is proposed that the chromatin in heterochromatic chromosomal regions is generally similar in its molecular composition to that in silenced chromosomal regions. Heterochromatic appearance hence reflects not a particular quality of the respective chromosomal regions but only a specific kind of chromatin packaging comparable to that required for the inactivation of genes. This packaging may be initiated by particular signals in the DNA but can be propagated over more extended chromosomal regions by the formation of multiprotein complexes that interact with histones and possibly cell-specific additional components (RNA or proteins) that determine the status of the chromosome in a particular cell type.

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Section: Heterochromatin As a State Of Chromatinmentioning

confidence: 99%

Heterochromatin

Hennig¹

1999

Chromosoma

127

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“…Although it has been long proposed that heterochromatin formation involves significant structural changes that could interfere with transcriptional activation and other DNA‐dependent processes (see e.g. [6–8]), the precise structural changes in DNA folding upon condensation of repressed chromatin have remained obscure.…”

Section: Introductionmentioning

confidence: 99%

Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays

Grigoryev

2004

FEBS Letters

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Interphase eukaryotic nuclei contain di¡use euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin ¢bers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays.

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“…4D). Thus, a Pc-G complex may not be made up of a single type of repeating unit (i.e., leading to a periodic structure) but, is likely to be an aperiodic structure that is made up of different types of repeating unit, as previously suggested (50) (Fig. 4D).…”

Section: Figurementioning

confidence: 60%

Mammalian chromodomain proteins: their role in genome organisation and expression

Jones¹,

Cowell²,

Singh³

2000

Bioessays

Self Cite

263

167

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The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124–137, 2000. ©2000 John Wiley & Sons, Inc.

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Chromatin complexes as aperiodic microcrystalline arrays that regulate genome organisation and expression

Cited by 24 publications

References 71 publications

Heterochromatin

Heterochromatin

Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays

Mammalian chromodomain proteins: their role in genome organisation and expression

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