Chromatin at the Intersection of Disease and Therapy

Quénet, Delphine; Walkiewicz, Marcin P.; Dalal, Yamini

doi:10.1002/9781118349045.ch4

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2018

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“…The crucial question is whether the chaperone–histone mis-interactions listed above, driven by mutation, mis-expression, or mis-regulation, can serve as therapeutic targets in the treatment of disease 98 . What makes such interactions an attractive target is precisely that they do not exist in normal cells.…”

Section: Discussionmentioning

confidence: 99%

The Art of War: harnessing the epigenome against cancer

2018

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Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histone variants H3.3 and CENP-A, specifically HIRA, DAXX/ATRX, DEK, and HJURP. This review summarizes recent studies elucidating their roles in regulating chromatin and discusses how cancer-specific chromatin interactions can be exploited to target cancer cells.

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Section: Discussionmentioning

confidence: 99%