Paper was invented in China in the centuries before Christ and carried by Buddhist monks throughout East and Central Asia (Tsien, 1985), where Muslim Arabs encountered it in the eighth century CE. Muslims carried paper and papermaking to the Mediterranean region, and European Christians there learned how to make it by the twelfth century. Europeans not only forgot their debt to Muslim papermakers but also remained ignorant of paper's origins in China, so that when they first encountered Chinese paper in the sixteenth century, they thought that the Chinese must have learned the art of papermaking from the ancient Egyptians! Europeans then carried paper and papermaking, along with printing, throughout the globe. While the history of paper has traditionally been overshadowed by the history of printing, the spread of paper and papermaking is arguably equally important, for this relatively permanent, cheap, and flexible material not only encouraged the spread of written culture across the globe but also transformed many other human activities.This paper studies mobilities of knowledge from the perspective of paper making by examining how and when this technique diffused from China across Eurasia to the Mediterranean region and from there to the rest of Europe in the period between 600 and 1500. The main factors that enhanced and impeded this spatial diffusion of knowledge were the availability of raw materials and the adoption of differing technologies, but the roles of mediating aspects such as religion, trade, emigration, imports, and exports will also be discussed.