Christ's Hospital 1978–79: An account of two outbreaks of influenza A H1N1

Davies, Joan R.; Smith, Alyson; Grilli, E. A.; Hoskins, T. W.

doi:10.1016/s0163-4453(82)91743-1

Cited by 11 publications

(8 citation statements)

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“…Studies on reinfection with type A influenza (H3N2 and H1N1) virus have been increasing recently [3][4][5][6][7][8][9]. The present study attempted to extend these observations by reviewing six epidemics due to three subtypes of influenza A virus (H2N2, H3N2, and H1N1) through measurement of HAI titers of paired sera taken before and after the epidemics from juveniles and young adults in closed populations in Japan.…”

Section: Discussionmentioning

confidence: 99%

Reinfection with Influenza A (H2N2, H3N2, and H1N1) Viruses in Soldiers and Students in Japan

Sonoguchi¹,

Sakoh²,

Kunita³

et al. 1986

Journal of Infectious Diseases

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Reinfection with influenza A virus was studied by measuring hemagglutination-inhibiting antibody responses to infection in paired sera taken from groups of soldiers and students. Among 62 soldiers severely infected during the first wave of the A/Asian/57 (H2N2) pandemic in 1957, 17 were asymptomatically reinfected with the same virus within six months. In the 1962 epidemic the rate increased to 41%. Among reinfected soldiers studied, 68% had an asymptomatic infection; only 10% were severely symptomatic, and they were found to be infected with a virus closely related to A/Asian/57. For H3N2 epidemics, the rate of reinfection was 17% among students studied in 1970 who were reinfected with a virus closely related to the prototype A/Hong Kong/68 (H3N2). Reinfection with an extremely drifted variant of H3N2 was found to be 32% and 69% in two groups of students studied in 1972. Reinfection with a related virus was 32% in another group studied in 1983. Among the students studied who were reinfected with H3N2 viruses, the rates of asymptomatic infection were similar to those of symptomatic infection. The reinfection rates with a virus related to A/USSR/77 (H1N1) were 9.3% and 20% in two groups studied in 1980.

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Section: Discussionmentioning

confidence: 99%

Reinfection with Influenza A (H2N2, H3N2, and H1N1) Viruses in Soldiers and Students in Japan

Sonoguchi¹,

Sakoh²,

Kunita³

et al. 1986

Journal of Infectious Diseases

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“…There was an outbreak of influenza caused by influenza A HlN1 in February 1978 when there were 420 clinical cases. It was estimated that 90 % of all the boys in school were infected (Davies et al 1982). In the Spring of 1979 there was a further small outbreak caused by this subtype, which affected mainly those boys who had joined the school in the previous autumn.…”

mentioning

confidence: 99%

Influenza A: infection and reinfection

Davies

Grilli

Smith

1984

J. Hyg.

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Twenty-nine boys in a boarding school were present during a large outbreak of influenza A H1N1 in 1978 when 27 were infected, 21 with clinical influenza. These boys were bled annually and were still in school when another outbreak of influenza A H1N1 occurred in 1983. Twenty-three of them were reinfected but only nine had symptoms. These results are compared with the experience of a similar group of boys in the early years of the influenza A H3N2 era.

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“…There was some evidence of asymptomatic infection and a small number of reinfections in boys with antibody before the outbreak. This outbreak and the one in 1978 have been described previously (Davies et al 1982).…”

Section: The Outbreaksmentioning

confidence: 56%

Infection with influenza A H1N1: 1. Production and persistence of antibody

Grilli

Davies

Smith

1986

J. Hyg.

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SUMMARYThree outbreaks of influenza caused by influenza A H1N1 occurred in a boys' boarding school in 1978, 1979 and 1983. The serological response to infection with variants of the H1N1 virus was studied by radial haemolysis and haemagglutination inhibition after primary infection and reinfection. The persistence of this antibody was also studied. Infection in 1978 resulted in the production of persistent antibody to both the haemagglutinin and neuraminidase of the homotypic strain. Antibody which cross-reacted with later variants of the virus was less frequently produced, the peak response was delayed and such antibody persisted less well. Infection in 1979 resulted in a similar response to that observed in 1978 after primary infection. Reinfection resulted in a broad response in all cases. In 1983 all infected boys produced antibody which reacted with the homotypic strain but only approximately one-third of primary infections produced antibody which reacted with the A/USSR/92/77 strain. The neuraminidase of the A/USSR strain failed to detect one third of the primary infections. Reinfection again resulted in a broad response.

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Christ's Hospital 1978–79: An account of two outbreaks of influenza A H1N1

Cited by 11 publications

References 1 publication

Reinfection with Influenza A (H2N2, H3N2, and H1N1) Viruses in Soldiers and Students in Japan

Reinfection with Influenza A (H2N2, H3N2, and H1N1) Viruses in Soldiers and Students in Japan

Influenza A: infection and reinfection

Infection with influenza A H1N1: 1. Production and persistence of antibody

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