Choronic effects of Lamotrigine on liver function in adult male rats

Abstract

A number of newly developed antiepileptic drugs are currently in use, among them Lamotrigine (LTG) is more common. Despite the extensive use of this drug, it has not been possible to predict the side effects especially the hepatotoxic reactions after long-term treatment. The present study was designed to find out alterations in the activities of liver enzymes after chronic exposure of rats to different dose of LTG. Adults male (Wistar) rats were treated orally with LTG [5 mg/kg body weight or 25mg/kg body wt.] for 60 days. After the experimental period, auto analyzer carried out liver function tests. The liver histopathology was obtained after scarifying the rats.There was a significant increase in the level of ALP, AST, ALT and bilirubin at therapeutic dose of LTG. The increase level of these enzymes and bilirubin at toxic dose were much higher and significant. However, the total protein and albumin significantly decreased at toxic dose of LTG. Elevation of liver enzymes and bilirubin after chronic exposure of rats to high dose of LTG reflects hepatocellular damage that may lead to hepatitis. It is concluded that regular liver function and drug monitoring should follow the treatment with LTG.

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

“…In liver damage due to DMH, there is defective excretion of bile which is reflected in increased level of ALP in the serum [44]. Elevated level of serum bilirubin is a very sensitive test to substantiate loss of functional integrity of liver and severity of necrosis [45]. Depletion of elevated bilirubin level along with decrease of ALP activity in the serum of mice treated with DMH?Triphala suggests that Triphala stabilizes the biliary dysfunction due to DMH.…”

Effect of ethanolic leaf extract of Trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats

“…Hyperbilirubinaemia is a very sensitive test to substantiate the functional integrity of the liver and severity of necrosis which increases the binding, conjugating and excretory capacity of hepatocytes that is proportional to the erythrocyte degeneration rate (24,25). Depletion of elevated bilirubin level together with the suppression of the activity of ALP in the serum of rats treated with ethanolic leaf extracts of T. portulacastrum suggests the possibility of phytotherapeutic option being able to stabilize biliary dysfunction of rat liver during chronic injury with aflatoxin.…”

Teratogenic Effect of Lamotrigine on Developing Liver of Swiss Albino Mice

“…The level of these enzymes and bilirubin at toxic dose were seen higher and showed a significant increase [10]. A significant increase in both ALT & AST liver enzymes, a decrease in TBARS content with an increase in the activities of both catalase and glutathione reductase enzymes was also reported in rats with induced convulsion, treated by LTG [11].…”