Choroidopathy in patients with systemic lupus erythematosus with or without nephropathy

Abstract

ICG-A can provide information that is not detectable by clinical or FAG examination in patients with lupus nephritis (group A). The findings of choroidopathy by ICG-A represent an indicator of ocular involvement and could be an indirect sign of renal involvement. Given that histological lesions may be present where there are no anomalies in urinary sediment and/or proteinuria, the positivity of ICG-A could help in deciding whether or not to carry out a renal biopsy. Therefore, ICG-A could be useful in the screening of patients with SLE, especially where there are no evident signs of renal involvement.

Choroidal Thickness in Patients with Systemic Lupus Erythematosus Analyzed by Spectral-domain Optical Coherence Tomography

“…8,9 The choroid has been shown to be affected in patient of SLE in several experimental and clinical studies. [10][11][12][13][14][15][16] Enhanced depth imaging optical coherence tomography (EDI-OCT), which is a recent modification of the standard OCT technique, offers a noninvasive, rapid, objective, and reliable diagnostic modality for the imaging of choroidal alterations and allows in vivo examination and quantification of the choroid. [17][18][19] However, there has been no study of the effect of SLE on choroidal thickness (CT) with EDI-OCT.…”

Punctate inner choroidopathy in systemic lupus

“…Choroidal manifestations of systemic lupus occur infrequently; only few cases were reported in the literature [3,4]. These manifestations include particularly choroidal ischemia with subsequent exudative retinal detachment, which is generally seen in patients who have highly active disease with uncontrolled arterial hypertension.…”

“…Letter to the editor In such cases, a general assessment should be performed, because choroidopathy in systemic lupus may be a signal of subclinical flare of the disease [4].…”

Ocular Manifestations in Systemic Lupus Erythematosus

“…Choroid: Choroidal disease is less common than retinopathy [5]. Although it is rare, it is considered a sensitive indicator of systemic disease activity [89]. Choroidopathy with exudative retinal detachment is a rare ocular manifestation [4].…”

“…Pinpoint spots of ICG choroidal hyperfluorescence appearing from the intermediate to late phases, may indicate ICG staining with localized abnormal fixing of the ICG molecule. They may represent immune deposits at the level of choroidal stroma, Bruch membrane or retinal pigment epithelial basement membrane that contain immunoglobulins and leukocytes which have been shown to bind the ICG molecule [89].…”