Choroidal vascularity index determined by binarization of enhanced depth imaging optical coherence tomography images in eyes with intermediate age-related macular degeneration

Özçalışkan, Şehnaz; Balcı, Sevcan; Yenerel, Nursal Melda

doi:10.1177/1120672120919341

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…The software analysis considers the areas of dark pixels as luminal areas (LAs), while the totality of the pixels in the ROI defines the total area (TA). The ratio between TA and LA is the formula applied to calculate CVI ( Figure 2 ) [ 49 , 112 , 115 ].…”

Section: Choroidal Imaging and Assessment In Vivomentioning

confidence: 99%

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Fragiotta¹,

Scuderi

Iodice³

et al. 2022

IJMS

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The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) expression, complement dysregulation, leukocyte interaction at Bruch’s membrane, and mast cell infiltration of the choroid. A mechanistic link between high-risk genetic loci for AMD and mast cell recruitment has also been recently demonstrated. Recent advances in multimodal imaging allow more detailed visualization of choroidal structure, identifying alterations that may expand our comprehension of aging and AMD development.

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Section: Choroidal Imaging and Assessment In Vivomentioning

confidence: 99%

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Fragiotta¹,

Scuderi

Iodice³

et al. 2022

IJMS

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“…The results of the research indicate that CVI is a parameter with lower variability and is influenced by fewer physiological factors compared to the thickness of the choroid, therefore it can be considered a relatively stable parameter for the assessment of changes in choroidal microcirculation 20 . CVI values in patients with age related macular degeneration appeared to be significantly lower in patients with AMD compared to healthy controls 22 , 23 . In addition, CVI has been shown to decrease with disease duration 24 .…”

Section: Introductionmentioning

confidence: 73%

The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

Krytkowska

Grabowicz

Mozolewska-Piotrowska

et al. 2021

Sci Rep

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Disturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β = + 0.18, p = 0.0007, β = + 0.18, p = 0.0008, respectively) and to dry AMD (β = + 0.17, p = 0.00003 for both ATC and AVC and β = − 0.30 p < 0.0001 for CVI). ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). The duration of hypertension was inversely correlated with ATC, AVC and AV (Rs = − 0.13, p < 0.05; Rs = − 0.12; p < 0.05, Rs = − 0.12; p < 0.05, respectively) while IHD duration negatively correlated with AV (Rs = − 0.15, p < 0.05). No such associations were observed in the control group. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.

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“…CVI defines the proportion of the vascular component in the choroid through a ratio of luminal area compared to the total choroidal area [4,12]. This index quantitatively and precisely analyzes the choroidal vascular system, enabling quantification of the proportion of choroidal vasculature, which is useful in the evaluation and management of several retinal and choroidal disorders [13].…”

Section: Choroidal Vascularity Index (Cvi) Assessmentmentioning

confidence: 99%

“…Some authors have studied the choroid in eyes with AOFVD as this prevalently vascular layer is fundamental in providing metabolic support to the RPE and outer retina. Indeed, the choroid is involved in various diseases, such as age-related macular degeneration (AMD), subretinal drusenoid deposits (SDD), and central serous chorioretinopa-thy [4][5][6]. A few authors have reported increased choroidal thickness (CT) in eyes with AOFVD [7,8], while Palacios et al found similar CT in eyes with AOFVD and eyes of healthy age-matched controls.…”

Section: Introductionmentioning

confidence: 99%

Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

et al. 2021

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This pilot study aims to investigate choroidal vascular status in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD), early age-related macular degeneration (AMD), and age-matched controls. In this retrospective study, choroidal thickness (CT) was measured manually using spectral domain optical coherence tomography images of the fovea, and 500 and 1500 µm from the nasal and temporal regions in the fovea. The horizontal B-scan was imported into Fiji software. Choroidal vascularity index (CVI) and luminal and stromal areas were calculated. A total of 36 eyes from 36 patients, including 18 eyes with AOFVD and 18 eyes with CD, and 16 eyes of healthy subjects were included. CVI was significantly different among subgroups (ANOVA, p = 0.004). Eyes with AOFVD presented a higher CVI (+0.03 ± 0.01, p = 0.001) than eyes with CD and controls (p = 0.03). No differences in CVI were detected between controls and eyes with CD (p = 0.25). AOFVD eyes accounted for the greatest luminal area, particularly significant in comparison with healthy controls (+0.27 ± 0.11, p = 0.02). AOFVD eyes present a greater CVI than eyes with CD and controls. The major choroidal involvement is on the luminal component, further corroborating a possible role of the choroidal vasculature in the pathological manifestations of AOFVD disease.

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Choroidal vascularity index determined by binarization of enhanced depth imaging optical coherence tomography images in eyes with intermediate age-related macular degeneration

Cited by 9 publications

References 28 publications

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

Choroidal Vascularity Index in Adult-Onset Foveomacular Vitelliform Dystrophy: A Pilot Study

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