Choroidal thickness measurement in children using optical coherence tomography

Garnier, M Bidaut; Schwartz, Christian; Puyraveau, Marc; Montard, M; Delbosc, B.; Saleh, Maher

doi:10.1111/j.1755-3768.2013.f067.x

Cited by 19 publications

(31 citation statements)

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“…The finding of a choroidal thickness increase from age 11 to 16 years corresponds to cross-sectional observations from white European and Australian children, [14][15][16] and the magnitude of subfoveal choroidal thickness increase in our study was similar that of Read et al 21 We also confirmed a reduced increase in choroidal thickness-in some cases choroidal thinning-in eyes that added more axial length. 21,23 While Asian studies in general report a mean decrease in choroidal thickness with increasing age in children, 1,[17][18][19][20]23 a recent cross-sectional study of 3001 Chinese children aged 6 to 19 years only found choroidal thinning in myopic eyes, whereas the choroid increased in thickness in nonmyopic eyes.…”

Section: Discussionsupporting

confidence: 91%

“…Some of them indicate that choroidal thickness decreases during adult life. 4,[10][11][12][13] In children and adolescents, cross-sectional studies suggest an increase in thickness with age in European and Australian cohorts, [14][15][16] whereas a decrease has been noted in Asian child cohorts. 1,[17][18][19][20] Given this complexity, it is obvious that prospective studies are particularly valuable.…”

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confidence: 99%

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Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Hansen

Larsen

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We describe changes in choroidal thickness from age 11 to 16 years and its association with ocular biometrics and body development. METHOD. In this longitudinal, population-based observational study, choroidal thickness was measured subfoveally and 1-and 3-mm temporal thereof using enhanced depth imaging spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted for age and the time of day that the scan was performed. RESULTS. The study included 687 participants (304 boys). Median (interquartile range [IQR]) age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in choroidal thickness was 33, 27, and 11 lm at the three respective locations. The subfoveal choroid thickened less in eyes whose axial length increased more (boys, b ¼ À85 lm/mm; 95% confidence interval [CI], À104 to À66, P < 0.0001; girls, b ¼ À105 lm/mm; 95% CI, À121 to À89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11 lm/diopters [D]; 95% CI, 4.0 to 18, P ¼ 0.0022; girls, 22 lm/D; 95% CI, 16 to 27, P < 0.0001). Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner stage 4 vs. 1; À39 lm' 95% CI, À72 to À5.9, P ¼ 0.021) and who had a longer baseline axial length (b ¼ À8.6 lm/mm; 95% CI, À15 to À2.7, P ¼ 0.0043), and more in girls who grew taller (b ¼ 0.9 lm/cm; 95% CI, 0.1 to 1.7, P ¼ 0.026). CONCLUSIONS. The choroid increased in thickness from age 11 to 16 years. The increase was greater in girls with later sexual maturation and smaller in eyes that added more axial length and had a relatively negative refractive development.

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Hansen

Larsen

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…39 However in pediatric population the correlation between age and CT is controversial. 33,36,40 In our study, age and CT correlated positively, although it was statistically insignificant. As the ocular growth might be disrupted in IGHD, the difference may not be statistically significant.…”

Section: Discussioncontrasting

confidence: 47%

Choroidal thickness measurements in children with isolated growth hormone deficiency

Yalçın

Aktaş

Yüce

et al. 2017

Eye

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PurposeThe aim of this study was to determine the choroidal thickness measurement values in cases with isolated growth hormone deficiency (IGHD), to compare them with the healthy control group by using enhanced depth imaging optical coherence tomography (EDI-OCT), and to evaluate the effect of growth hormone (GH) treatment on choroid.Patients and methodsIn this study, 23 cases who were diagnosed with IGHD as a study group and 46 healthy subjects as a control group were included. All patients and controls underwent a complete ophthalmologic examination, including an examination with EDI-OCT. Choroidal thickness (CT) was measured at the fovea and at 1000 μm intervals from the foveal center in both temporal and nasal directions.ResultsThe mean subfoveal choroidal thickness (SFCT) was 329.04±88.49 μm in the cases with IGHD and 365.35±50.48 μm in the control group (P=0.033). The mean CT at temporal 1 and 2 mm were thinner in the IGHD group than that of control group (P=0.033 and P=0.043, respectively). Nasal quadrant measurements were also found to be thinner in the IGHD cases than that of control group, but the difference was not statistically significant. We found a significant positive correlation between pubertal staging and SFCT (r=0.607, P=0.006). There was no statistically significant difference in CT values of the study group between before and 12 months after GH treatment (P>0.05).ConclusionThis study shows patients with IGHD has a thinner CT when compared with healthy pediatric cases. GH treatment seems to be not associated with the choroidal development.

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“…Normal choroidal thickness has also been examined in healthy children and adolescents, and estimates of the mean subfoveal choroidal thickness in paediatric populations from these studies have ranged from 245 to 361 μm . Consistent with studies of adults, most studies also note substantial between‐subject variability in subfoveal choroidal thickness measures in children.…”

Section: The Normal Thickness Of the Human Choroidmentioning

confidence: 80%

“…Studies examining the relationship between age in childhood and choroidal thickness, that have primarily included emmetropic children in their analyses, have noted that choroidal thickness tends to increase significantly with age in childhood . In contrast to this, studies including large proportions of myopic children in their analyses have typically noted a significant decrease in choroidal thickness with age, indicating an interaction between the development of myopia and normal developmental changes in the choroid in childhood.…”

Section: The Normal Thickness Of the Human Choroidmentioning

confidence: 99%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Read

Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

117

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The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically improved our knowledge of the normal choroid, and its potential role in the regulation of eye growth and refractive error development. This review aims to provide an overview of recent work examining the normal human choroid, its changes with myopia and the possible role of the choroid in the mechanism regulating eye growth. Studies have demonstrated that choroidal thinning accompanies the development and progression of myopia, and have established a close link between eye growth and choroidal thickness changes. Dramatic thinning of the choroid is seen with high myopia, and associations are also observed between choroidal thinning and reduced vision, and the development of retinal pathology associated with high myopia. In the short-term, environmental factors known to be associated with myopia development and more rapid eye growth typically lead to a thinning of the choroid, whereas factors linked to a slowing of eye growth are typically associated with short-term choroidal thickening. Collectively, these findings suggest that the choroid is an important biomarker of eye growth in the human eye, and additional research to better understand the human choroid is likely to further our knowledge of the signals and pathways regulating eye growth, myopia development and progression.

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Choroidal thickness measurement in children using optical coherence tomography

Cited by 19 publications

References 0 publications

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Choroidal thickness measurements in children with isolated growth hormone deficiency

Choroidal changes in human myopia: insights from optical coherence tomography imaging

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