Choroidal Thickness in Systemic Arterial Hypertension

Akay, Fahrettin; Gündoğan, Fatih Ç.; Yolcu, Ümit; Toyran, Sami; Uzun, Salih

doi:10.5301/ejo.5000675

Cited by 124 publications

(98 citation statements)

References 22 publications

(26 reference statements)

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“…[252627] The present study revealed reduced SFCT in CADASIL patients. Young adults with systemic arterial hypertension were shown to have significantly lower SFCT as compared to that in healthy controls.…”

Section: Discussionmentioning

confidence: 49%

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Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Fang

et al. 2017

Chinese Medical Journal

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Background:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation. We performed enhanced depth imaging optical coherence tomography (EDI-OCT) to evaluate the retinal vessel changes in CADASIL patients and assessed their consonance with brain magnetic resonance imaging (MRI) findings.Methods:Of 27 genetically confirmed patients and an equal number of controls were recruited at the Peking University First Hospital from January 2015 to August 2016. All patients underwent 7T-MRI of the brain. Fazekas score, number of small infarcts and microbleeds were evaluated. All patients and controls underwent EDI-OCT to measure subfoveal choroidal thickness (SFCT), inner and outer diameters as well as arterial and venous wall thickness, and arterial venous ratio of the inner (AVRin) and outer diameters (AVRout). The relation between retinal vessel changes and Fazekas scores, numbers of small infarcts, or microbleeds was analyzed. Paired t-test was used to compare the SFCT and retinal vessel measurement data between patients and controls. Spearman's correlation was used to investigate the correlation between retinal vessel changes and MRI lesions.Results:In CADASIL patients, mean SFCT (268.37 ± 46.50 μm) and mean arterial inner diameter (93.46 ± 9.70 μm) were significantly lower than that in controls (P < 0.001, P = 0.048, respectively). Mean arterial outer diameter (131.74 ± 10.87 μm), venous inner (128.99 ± 13.62 μm) and outer diameter (164.82 ± 14.77 μm), and mean arterial (19.13 ± 1.85 μm) and venous (17.91 ± 2.76 μm) wall thickness were significantly higher than that in controls (P = 0.023, P = 0.004, P < 0.001, P < 0.001, respectively). Arterial inner diameter (rs= −0.39, P = 0.044), AVRin (rs= −0.65, P < 0.001), and AVRout (rs= −0.56, P = 0.002) showed a negative correlation with the number of small infarcts. Venous inner diameter (rs = 0.46, P = 0.016) showed a positive correlation with the number of small infarcts. Venous inner diameter (rs = 0.59, P = 0.002), outer diameter (rs = 0.47, P = 0.017), showed a positive correlation with the number of cerebral microbleeds (CMBs). AVRin (rs= −0.52, P = 0.007) and AVRout (rs= −0.40, P = 0.048) showed a negative correlation with the number of CMBs.Conclusions:Measurement of retinal vessels using EDI-OCT correlates moderately well with MRI parameters. EDI-OCT might be a useful evaluation tool for CADASIL patients.

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Section: Discussionmentioning

confidence: 49%

“…Young adults with systemic arterial hypertension were shown to have significantly lower SFCT as compared to that in healthy controls. [25] Thinner SFCT is also seen in diabetic patients without diabetic retinopathy,[2627] and in patients with migraine. [28] In addition, a decrease in mean SFCT was also described in ocular ischemic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Fang

et al. 2017

Chinese Medical Journal

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“…Despite the fact that the patients in the two treatment groups had comparable baseline characteristics, this limitation might have influenced the results of this study. Previous studies have shown that the choroidal thickness is associated with various factors, including diurnal variation,26 refractive error or axial length,27 and the presence of hypertension,28 and diabetes mellitus 29. Additionally, the intake of water30 or coffee31 can also influence the choroidal thickness.…”

Section: Discussionmentioning

confidence: 99%

Short-term choroidal thickness changes in patients treated with either ranibizumab or aflibercept: a comparative study

et al. 2016

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“…[4][5][6][7][8] In addition, it is known that ChT is affected by various factors such as blood pressure, age, gender, time of the day, refractive status, axial length, and forced hyperopic or myopic defocus. 2,[9][10][11] Further, a recent experimental study showed that anti-muscarinic agents could affect ChT. 12 Therefore, in the present study, we aimed to investigate the effects of tropicamide and cyclopentolate, which are two anti-muscarinic agents commonly used in the ophthalmologic practice, on subfoveal ChT measured by EDI OCT in healthy adults.…”

Section: Introductionmentioning

confidence: 99%

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

Öner

Bulut

Öter

2016

Eye

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Purpose To investigate the effects of tropicamide and cyclopentolate, which are two anti-muscarinic agents commonly used in the ophthalmologic practice, on subfoveal choroidal choroidal thickness (ChT) in healthy adults. Methods A total of 74 healthy adult subjects were enrolled in the study. Subjects were randomly divided into two groups: (1) cyclopentolate group (n = 37) in which the right eye (study eye) of each subject received topical cyclopentolate 1%, and the fellow eye (control eye) received artificial tears and (2) tropicamide group (n = 37) in which the right eye (study eye) of each subject received topical tropicamide 1% and the fellow eye (control eye) received artificial tears. Each topical medication was applied three times with 10-min intervals. ChT measurements were performed at baseline and 40 min after the last drops of the topical medications by enhanced depth imaging (EDI) optical coherence tomography (OCT). Results In the cyclopentolate group, subfoveal ChT significantly increased in the study eyes (P = 0.013), whereas it did not significantly change in the control eyes (P = 0.417). On the other hand, in the tropicamide group, no significant subfoveal ChT changes were observed in either the study eyes (P = 0.715) or the control eyes (P = 0.344). Conclusions The current study demonstrated that cyclopentolate caused significant choroidal thickening, whereas tropicamide had no significant effect on ChT in healthy adults. As a result, mydriasis by cyclopentolate may complicate ChT measurements by EDI OCT. Use of tropicamide may provide more reliable results for evaluation of ChT in ocular pathologies.

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Choroidal Thickness in Systemic Arterial Hypertension

Abstract: The results of this study demonstrated that choroidal thickness decreases in patients with systemic arterial hypertension. This may be caused by arteriolar sclerosis and vascular contraction caused by high intravascular pressure in the choroid.

Cited by 124 publications

References 22 publications

Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Short-term choroidal thickness changes in patients treated with either ranibizumab or aflibercept: a comparative study

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

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