Choroidal thickness in relation to sex, age, refractive error, and axial length in healthy Turkish subjects

Abstract

The aim of this study was to investigate the association between choroidal thickness (CT) and sex, age, refractive error (RE), and axial length in healthy subjects. This is a study of 154 eyes in 154 healthy subjects. CT measurements were performed by the same experienced technician using a spectral domain optical coherence tomography device. CT was measured perpendicularly from the outer edge of the retinal pigment epithelium to the choroid-sclera boundary at the fovea and at six more points which are located at, respectively, 500 µm nasal to the fovea, 1,000 µm nasal to the fovea, and 1,500 μm nasal to the fovea, 500 μm temporal to the fovea, 1,000 μm temporal to the fovea, and 1,500 μm temporal to the fovea. The RE was measured by autorefractometry, and the axial length was measured by interferometry. Statistical analysis was performed to evaluate CT at each location, and to the correlations of CT with sex, age, RE, and axial length. The mean subfoveal CT was 265.86 ± 60.32 µm, the mean age was 49.01 ± 19.19 years, the mean RE was -0.17 ± 1.20 diopters (D), and the mean axial length was 23.39 ± 0.76 mm. CT profile indicated that the choroid was thicker at the fovea than at temporal and nasal locations. Univariable linear regression analysis showed that subfoveal CT decreased 3.14 µm for each year of age and decreased 79.33 µm for each mm of axial length (P = 0.000, R(2) = 0.249; P = 0.000, R(2) = 0.487, respectively). In a similar analysis, subfoveal CT was found to decrease by 50.24 µm/D myopia-shifted change in refraction (P = 0.000, R (2) = 0.201). The subfoveal choroid was 99.16 µm (39.22 %) thicker in men than women when adjusting for age and axial length (P = 0.000, R(2) = 0.249). CT decreases with increasing myopia, age, and axial length. Men had thicker choroid than women, and CT varies depending on location.

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

“…Correlation analysis for continuous variables was performed using the Pearson correlation coefficient when indicated. Linear regression analyses were used to compare choroidal thickness among the three groups with adjument for age, gender, and BCVA as these variables have previously been associated with a change in choroidal thickness (19)(20)(21) . Parameters significantly associated with choroidal thickness based on univariate analysis were incorporated into the regression model.…”

Association of choroidal thickness with eye growth: a cross-sectional study of individuals between 4 and 23 years

“…1 However, although our understanding of choroidal characteristics has increased substantially in recent years, only a few reports to date have provided values for choroidal thickness in children. [7][8][9] In a recent study, age and axial length (AL) were determined to be negatively correlated with choroidal thickness and volume in adults. 7 Similarly, in a previous study, we also demonstrated a decrease in choroidal thickness with increasing myopia, age, and AL in adults.…”

“…7 Similarly, in a previous study, we also demonstrated a decrease in choroidal thickness with increasing myopia, age, and AL in adults. 8 However, although our understanding of choroidal characteristics has increased substantially in recent years, only a few reports to date have provided values for choroidal thickness in children. [9][10][11] Recently, an increase in choroidal thickness with age but an inverse correlation of choroidal thickness with AL was also reported in healthy children aged 3.5-14.9 years.…”

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome

“…Turkiye Klinikleri J Ophthalmol 2018;27(1): [39][40][41][42][43][44] daha ince bulunur iken regresyon analizlerinde refraktif kusurun koroid kalınlığı üzerinde büyük etkiye sahip olduğu gösterilmiştir. [37][38][39][40][41] Yapılan ça-lışmalarda, subfoveal koroid kalınlığı/dioptri değişiminin 9,3-13,6 µm olduğu gösterilmiştir.…”

“…tarafından yapılan çalışmada anlamlı korelasyon izlenmemiştir. 40,43 Çalışmamızda PEX sendromlu bireylerde nazal alanda anlamlı koroidal incelme saptanmış olsa da diğer alanlarda da incelme izlenmiştir. Bu sonuç, PEX sendromunda koroidal dolaşımın materyal birikimi ile etkilendiğini ve koroid kalınlığı-nın azaldığı görüşünü desteklemektedir.…”