Choroidal thickness in preeclampsia measured by spectral-domain optical coherence tomography

Benfica, Camila Zanella; Zanella, Teresinha; Farias, Lucas Brandolt; Oppermann, Maria Lúcia Rocha; Canani, Luís Henrique Santos; Lavinsky, Daniel

doi:10.1007/s10792-018-1043-7

Cited by 15 publications

(10 citation statements)

References 29 publications

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“…e area of choroidal capillary flow in the PE group was lower than that of healthy pregnant women, which is likely related to the vascular tissue edema caused by choroidal hyperperfusion or to vasospasm, where the placenta is invaded, but this needs to be confirmed. However, Kim et al [46] and Benefica et al [47] found that the choroid of patients with PE was significantly thicker than that of nonpregnant and healthy pregnant women. e choroidal thickness of patients with sPE was the highest.…”

Section: Hypertensive Choroidopathymentioning

confidence: 97%

“…When edema and necrosis of the RPE develop, the outer bloodretinal barrier is destroyed, causing choroidal leakage under the retina and forming a serous separation. SRD complicated with PE is mostly reported in the form of case reports [47,63]. Altalbishi et al [63] not only reported a case of a pregnant woman with limited SRD but also summarized the fundus changes in PE patients after secondary SRD.…”

Section: Srd Srd Is a Complication Of Pe First Proposed By Vonmentioning

confidence: 99%

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Chorioretinal Alterations Induced by Preeclampsia

et al. 2021

Journal of Ophthalmology

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Hypertension during pregnancy, which is essentially a microvascular disease that destroys the end-organ microcirculation, should not be underestimated, as it could lead to organ failure in the kidneys, lungs, and brain. Preassessment of the microcirculatory state through systematic observation of the fundus has been proven to be noninvasive and feasible. Although hypertension in preeclampsia patients will resolve after childbirth, the sticking point is determining the best termination moment. Early diagnosis and treatment can prevent long-term ocular complications and cardiovascular risks for pregnant women in the future. In order to adjust the treatment strategy through more sensitive and precise fundus changes, we comprehensively summarized the common structural changes in the fundus in preeclampsia patients, including changes in the blood vessels, choroid, and retina, as well as the application of quantitative observation for chorioretinal alterations in recent years.

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Section: Hypertensive Choroidopathymentioning

confidence: 97%

Section: Srd Srd Is a Complication Of Pe First Proposed By Vonmentioning

confidence: 99%

Chorioretinal Alterations Induced by Preeclampsia

et al. 2021

Journal of Ophthalmology

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“…Approximately 40% of patients with preeclampsia complain of subjective visual symptoms, including decreased vision, visual field defects, and numerous ocular changes, including increased central corneal thickness and corneal curvature, decreased corneal sensitivity, and intraocular pressure [ 5 – 7 ]. Changes in blood-ocular barrier, choroidal thickness (CT), and circulation in preeclampsia occur [ 8 – 10 ]. Additionally, in preeclampsia, circulating maternal anti-angiogenic factors, such as soluble fms-like tyrosine kinase 1 (sFlt-1), are increased, and placental growth factor (PlGF) levels are decreased.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

2021

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This study aimed to evaluate the correlation between ophthalmologic factors and the serologic indicator soluble fms-like tyrosine kinase 1 (sFlt-1): placental growth factor (PlGF) ratio in patients with preeclampsia using optical coherence tomography (OCT) and OCT angiography (OCT-A). A total of 52 pregnant patients (104 eyes) diagnosed with preeclampsia were recruited during their hospital stay. The associations between the sFlt-1/PlGF ratio and chorioretinal measurements, including the choroidal thickness (CT), foveal avascular zone, vascular density, and ganglion cell layer+ were evaluated. Central and nasal subfield CT of the left eye (p = 0.039; p = 0.010) and nasal subfield CT of the right eye (p = 0.042) were lower in the high sFlt-1/PlGF ratio group (≥38). Pearson’s correlation test showed a negative correlation between the sFlt-1/PlGF ratio and central subfield CT; however, this was not statistically significant (p = 0.648). Linear regression analysis revealed a significant association between the sFlt-1/PlGF ratio and central subfield CT (β coefficient, -6.66; p = 0.01) and between sFlt-1 and central subfield CT (β coefficient, -5.65; p = 0.00). Thus, an increase in the sFlt-1/PlGF ratio resulted in a decrease in central subfield CT.

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“…Kim et al, Ben ca et al and Sharudin etal. noted signi cantly greater choroidal thickness in patients with pre-eclampsia compared to the healthy pregnancy group [40,41,27]. This may suggest a correlation between choroidal thickness and ocular perfusion pressure; rather than pregnancy itself.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of Choroidal Thickness during Pregnancy and Post-partum: A Longitudinal Study

Alizadeh

Moravvej

Moghadam

et al. 2022

Preprint

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Purpose: This study aimed to assess the longitudinal changes of choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT) during pregnancy and post-partum.Methods: The study included 23 eyes of 23 healthy pregnant women and 23 eyes of 23 healthy non-pregnant women. Choroidal thickness (CT) was measured manually with EDI-OCT at seven locations: the fovea, 500, 1000 and 1500 μm temporal (T) from the fovea and 500, 1000 and 1500 μm nasal (N) from the fovea. Measurements were obtained at each pregnancy trimester and 6 weeks post-partum and in the follicular phase of the menstrual cycle for the control group.Results: The mean subfoveal choroidal thickness was 410.2 ± 82.4 μm, 434.8 ± 79.6 μm, 433.5 ± 80.3 μm, and 395.0 ± 71.1 μm in the first, second and third trimesters and 6 weeks post-partum, respectively. In all seven measured locations, statistically significant changes were noted during pregnancy and post-partum in the choroidal thickness (p<0.001). Choroidal thickness increased from the first trimester to the second and third trimester, after which it decreased at post-partum. Choroidal thickness was greater in the pregnant group during pregnancy and post-partum compared to the control group (p<0.001).Conclusion: This study indicated significant change in choroidal thickness at seven locations measured with EDI-OCT throughout pregnancy and 6 weeks after delivery. We showed that 6 weeks after delivery, choroidal thickness remains significantly higher than non-pregnant subjects.

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Choroidal thickness in preeclampsia measured by spectral-domain optical coherence tomography

Cited by 15 publications

References 29 publications

Chorioretinal Alterations Induced by Preeclampsia

Chorioretinal Alterations Induced by Preeclampsia

Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

Evaluation of Choroidal Thickness during Pregnancy and Post-partum: A Longitudinal Study

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