Choroidal thickness evaluation of healthy eyes, central serous chorioretinopathy, and fellow eyes using spectral domain optical coherence tomography in Indian population

Abstract

Aim:The purpose of this study is to establish a normative database of subfoveal choroidal thickness (CT) in healthy young Indians using spectral domain optical coherence tomography (SD OCT). Evaluation and comparison of CT of central serous chorioretinopathy (CSC) and fellow eyes were also performed.Materials and Methods:This was a prospective, cross-sectional, and observational study. It included 112 normal eyes of 112 healthy volunteers who had no evidence of ocular or systemic disease, 84 CSC eyes with acute, treatment-naïve CSC, and 69 fellow eyes with no evidence of neurosensory detachment or pigment epithelium detachment on SD OCT. Complete history, examination, and SD OCT were performed in all eyes.Results:The mean age of 81 patients (84 eyes) with CSC was 35.04 ± 8.86 years, 69 fellow eyes was 34.61 ± 8.71 years, and 112 healthy volunteers (112 eyes) was 33.16 ± 9.4 years (P < 0.05). The mean subfoveal CT of CSC eyes was 429 ± 74.18 μ, fellow eyes was 360 ± 57.99 μ, and normal eyes was 301.80 ± 46.59 μ (P < 0.001).Conclusion:CT varies not only with age, axial length, and refractive error but also with races. Therefore, it is important to establish a normative database in a particular population before carrying out further research in diseased states. CT in CSC eyes is significantly thicker than fellow eyes, and CT of fellow eyes is significantly thicker than normal eyes. This reinforces the fact that choroidal permeability is increased in both eyes of patients with CSC.

Subthreshold diode micropulse laser versus observation in acute central serous chorioretinopathy

“…For measuring choroidal thickness, the following protocol was adopted . The choroid was imaged in the macular line protocol by positioning the spectral domain optical coherence tomography instrument close enough to the eye to obtain an inverted image (choroidal mode, choroidal intensity +5).…”

Evaluation of Choroidal Thickness in Normal Eyes Using Enhanced Depth Optical Coherence Tomography

“…A wide variation in choroidal thickness was reported in various studies. Even in comparision with Indian studies 15,17 our measurement of choroidal thickness is significantly higher. This could be due to differences in Choroidal thickness in the inferior quadrant is lesser at all corresponding points compared to superior quadrant The average choroidal thickness in the superior quadrant observed in this study is 350.91 μm, which was not significantly different from the choroidal thickness in the subfoveal region.…”

Pachychoroid disease of the macula

“…4C-D), in certain cases of the character of a "factory chimney", in which the colouring rises upwards beneath the neurosensory retina, at other times as a progressively enlarging "ink stain". On ICGA we see deposits of choroidal vascular hyperpermeability especially in the middle phases of angiography [3,6,29].…”