Choroidal Thickness Changes after Orthokeratology Lens Wearing in Young Adults with Myopia

Lee, Jang Hun; Hong, In Hwan; Lee, Tae Yeem; Han, Jae Ryong; Jeon, Gang Seok

doi:10.1159/000510715

Cited by 13 publications

(15 citation statements)

References 29 publications

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“…Increased ChT has been associated with reduced eye growth [ 27 , 28 ] and so may have played a role in the reduced eye growth recorded in MOK-treated eyes over the course of the study. The reduced ChT that we observed in OK-treated eyes is contrary to the findings of most other studies, which report increases in choroidal thickness with conventional orthokeratology [ 22 , 29 ]. The reason for this inconsistency is not clear, although other studies have typically employed optical coherence tomography (OCT) to assess choroidal thickness, whereas we used ocular biometry (Lenstar) measures in the current study.…”

Section: Discussioncontrasting

confidence: 99%

Multifocal Orthokeratology versus Conventional Orthokeratology for Myopia Control: A Paired-Eye Study

Loertscher

Backhouse

Phillips

2021

JCM

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We conducted a prospective, paired-eye, investigator masked study in 30 children with myopia (−1.25 D to −4.00 D; age 10 to 14 years) to test the efficacy of a novel multifocal orthokeratology (MOK) lens compared to conventional orthokeratology (OK) in slowing axial eye growth. The MOK lens molded a center-distance, multifocal surface onto the anterior cornea, with a concentric treatment zone power of +2.50 D. Children wore an MOK lens in one eye and a conventional OK lens in the fellow eye nightly for 18 months. Eye growth was monitored with non-contact ocular biometry. Over 18 months, MOK-treated eyes showed significantly less axial expansion than OK-treated eyes (axial length change: MOK 0.173 mm less than OK; p < 0.01), and inner axial length (posterior cornea to anterior sclera change: MOK 0.156 mm less than OK, p < 0.01). The reduced elongation was constant across different baseline progression rates (range −0.50 D/year to −2.00 D/year). Visual acuity was less in MOK vs. OK-treated eyes (e.g., at six months, MOK: 0.09 ± 0.01 vs. OK: 0.02 ± 0.01 logMAR; p = 0.01). We conclude that MOK lenses significantly reduce eye growth compared to conventional OK lenses over 18 months.

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Section: Discussioncontrasting

confidence: 99%

Multifocal Orthokeratology versus Conventional Orthokeratology for Myopia Control: A Paired-Eye Study

Loertscher

Backhouse

Phillips

2021

JCM

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“…Over the one-year follow-up period, the study found that the SFChT became thicker in both eyes after orthokeratology, as was also reported in other studies [ 10 , 11 , 21 ]. Recent studies have suggested that the SFChT would change after orthokeratology lens wearing [ 22 , 23 ], with a significant thickening of the temporal choroid in the subfoveal area, but not in the nasal side [ 12 ].…”

Section: Discussionsupporting

confidence: 85%

“…Optical coherence tomography (ZEISS CIRRUS HD-OCT-5000) was used to measure the ChT of the subjects; the head position was fixed during the whole measurement. The “HD CROSS” test method and Enhanced Deep Imaging (EDI) mode were selected for standardized measurements [ 10 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…A previous study reported an increase in choroid thickness (ChT) in the myopic defocus animal model [ 9 ]. Clinical studies found that the subfoveal choroidal thickness (SFChT) changed after orthokeratology [ 10 , 11 ]. Chen et al [ 12 ] found increased ChT in subjects after three-week corneal shaping, which could be related to the effect of myopia control in orthokeratology lenses [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology

Chen

Liu

2022

JPM

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The changes in subfoveal choroidal thickness after orthokeratology are crucial in myopia retardation; this study aimed to identify the risk factors that could be incorporated into a predictive model for subfoveal choroidal thickness (SFChT) that would provide further personalized and clinically specific information for myopia control. A one-year prospective study was conducted in the West China Hospital, Sichuan University. Basic information (age, gender, and height) was collected from all subjects. Initial spherical equivalent, axial length, intraocular pressure, central corneal thickness, and subfoveal choroidal thickness were measured, and the ocular environmental factors were also collected. All the measured parameters were recorded in the follow-up period for one year. After the analysis of univariate analysis, statistically significant factors were substituted into the multivariate three-level model. Thirty-three adolescents aged 8–14 years old were enrolled in this study; the results show that the subfoveal choroidal thickness in both eyes changed significantly after 12 months of lens wearing (pR < 0.0001, pL < 0.0001). The axial length was negatively correlated with the change in the SFChT after 12 months of lens wearing (r = −0.511, p = 0.002). After multilevel model analysis, the statistically significant factor was shown to have an important influence on the changes in the subfoveal choroidal thickness, which was the average near-work time. This suggested that the SFChT personal predictions can be made regarding changes in myopic adolescents after orthokeratology using the factor of daily average near-work time. Clinical practitioners will benefit from the results by obtaining a better understanding of the effects of orthokeratology on choroid and myopia progression.

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“…After wearing orthokeratology lenses for a period as short as 3 to 4 weeks, myopic patients exhibited choroidal thickening. Further, after close-range reading for a short period, choroidal thickness is decreased [ 9 – 11 ]. This indicates that choroidal mechanisms are involved in regulating the refractive error in the human eye.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness and choriocapillaris vascular density in myopic anisometropia

et al. 2021

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Background This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia. Methods The sample comprised 44 participants with anisometropic myopia, aged 9 to 18 years, with normal best-corrected visual acuity. All participants underwent a series of examinations, including spherical equivalent refraction (SER) and axial length (AL), measured by a Lenstar optical biometer and optical coherence tomography angiography (OCTA) scanner. OCT measured the choroidal thickness, vascular density, and flow voids of the choriocapillaris, and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL. The choroidal thickness was measured at the fovea and 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm nasally, temporally, inferiorly, and superiorly to the fovea. The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle, and the 0.6–2.5 mm diameter circle in the nasal, temporal, inferior, and superior regions. Repeated-measured ANOVAs were used to analyze the interocular differences. Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness, the choriocapillaris vascular density and flow voids, the SER and AL. Results The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes (P ≤ 0.001), and the flow voids in the more myopic eyes were more than less myopic eyes (P = 0.002). There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes (P = 0.525). However, when anisometropia was more than 1.50 D, the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes (P = 0.026). The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center, superior, and inferior regions but not in the nasal or temporal regions. The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL. Conclusions The choroidal thickness is thinner in the more myopic eyes. The flow void is increased, and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.

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Choroidal Thickness Changes after Orthokeratology Lens Wearing in Young Adults with Myopia

Cited by 13 publications

References 29 publications

Multifocal Orthokeratology versus Conventional Orthokeratology for Myopia Control: A Paired-Eye Study

Multifocal Orthokeratology versus Conventional Orthokeratology for Myopia Control: A Paired-Eye Study

Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology

Choroidal thickness and choriocapillaris vascular density in myopic anisometropia

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