Choroidal structural changes in different intermediate AMD patterns

Viggiano, Pasquale; Toto, Lisa; Ferro, Giada; Evangelista, Federica; Porreca, Annamaria; Mastropasqua, Rodolfo

doi:10.1177/1120672121992009

Cited by 18 publications

(13 citation statements)

References 41 publications

(44 reference statements)

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“…CVI reduction in RPDs/SDDs was further confirmed in a recent study, where the eyes with drusen greater than 125 μm did not show significant changes compared with healthy controls [ 120 ]. CVI changes in AMD seem to follow a biphasic trend, with an initial increase during the earlier stages of AMD, followed by a progressive decrease in the advanced stages.…”

Section: Choroidal Imaging and Assessment In Vivomentioning

confidence: 54%

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Fragiotta¹,

Scuderi

Iodice³

et al. 2022

IJMS

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The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) expression, complement dysregulation, leukocyte interaction at Bruch’s membrane, and mast cell infiltration of the choroid. A mechanistic link between high-risk genetic loci for AMD and mast cell recruitment has also been recently demonstrated. Recent advances in multimodal imaging allow more detailed visualization of choroidal structure, identifying alterations that may expand our comprehension of aging and AMD development.

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Section: Choroidal Imaging and Assessment In Vivomentioning

confidence: 54%

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Fragiotta¹,

Scuderi

Iodice³

et al. 2022

IJMS

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“… 37 This observation is supported by the findings from one recent study reporting a lack of a significant difference in CVI between eyes with only RPD compared to eyes with large drusen. 38 Another study reported that the CVI was higher in non-neovascular AMD eyes with RPD compared to those without. 36 In that study, eyes with RPD also had a significantly lower luminal area (or extent of choroidal vessels) but did not have a significantly lower choroidal thickness.…”

Section: Discussionmentioning

confidence: 99%

“… 37 One study recently observed a significant difference in CVI between eyes with and without RPD, 36 but another study did not observe any significant differences. 38 …”

mentioning

confidence: 99%

Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography

Zhou

Chu

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose To examine the impact of reticular pseudodrusen (RPD) on choriocapillaris blood flow and choroidal structure in individuals with intermediate age-related macular degeneration (AMD). Methods Individuals with bilateral large drusen underwent optical coherence tomography (OCT), color fundus photography, near-infrared reflectance, and fundus autofluorescence imaging to determine the presence of RPD. These participants also underwent swept-source OCT angiography (SS-OCTA) imaging to determine (1) choriocapillaris flow deficit (FD) parameters, including the percentage, mean size, and number of FDs present; and (2) choroidal structural parameters, including mean choroidal thickness and choroidal vascularity index. Differences in these parameters between eyes with and without coexistent RPD were examined with and without adjustment for potential key confounders such as drusen volume from the SS-OCTA scans and age. Results This study included 102 eyes from 51 individuals with bilateral large drusen, and the analyses showed that there were no significant differences in the choriocapillaris FD parameters ( P ≥ 0.062 for all) and choroidal structural parameters ( P ≥ 0.059 for all), with or without adjustment for potential confounders in this cohort. However, the percentage of FDs and the mean FD size were both significantly greater with increasing drusen volume ( P ≤ 0.038 for both). Conclusions The coexistence of RPD in eyes of individuals with intermediate AMD was not associated with significant impairments in choriocapillaris blood flow and choroidal vascular structural changes, with or without adjustment for key confounders. These findings suggest that macular changes in these vascular parameters may not be associated with the presence of RPD.

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“…Second, we did not use an swept source – OCT system which is more reliable to evaluate deeper levels, although previous papers have shown the accuracy of EDI mode. 18,30,31 Third, CVI is still calculated on a single line B scan because of the restrictions of the CVI calculation software.…”

Section: Discussionmentioning

confidence: 99%

Femto-assisted versus conventional phacoemulsification differently impact on choroid structure after surgery

Appolloni

Viggiano

Carrella

et al. 2021

European Journal of Ophthalmology

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Purpose: To report potential choroidal changes in eyes undergoing femtosecond laser cataract surgery (FLACS) and phacoemulsification surgery (PCS) by OCT. Methods: The patients were images by means Spectral Domain OCT imaging with EDI technology which may obtain OCT image. We exported a single EDI-OCT scan passing through the fovea and then it was imported into ImageJ program to perform a quantitative analysis. Main outcome measures: The main outcome measures were: (i) sub foveal choroidal thickness (SFCT); (ii) the choroidal vascularity index (CVI); and (iii) central retinal thickness (CRT). Results: At postoperative 1 week, FLACS group showed an increased CRT (241.2 ± 31.6–245.5 ± 36.4 µm; p = 0.016). Likewise, CVI and SFCT exhibited a slight increase but no statistically differences were highlighted ( p > 0.05). At the follow-up visit of 1 month, all OCT parameters did not display any significant difference ( p > 0.05). At post-operative 1 week, the PCS group displayed a significant increase in CRT, SFCT, and CVI. On the contrary, at the follow-up visit of 1-month, all choroidal parameters were characterized by a no statistically significant reduction ( p > 0.05). Conclusions: Our study exhibited a significant increase in CT and CVI in eyes that underwent conventional cataract surgery. Femtosecond laser-assisted cataract extraction did not result in macular change due to less postoperative inflammation.

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Choroidal structural changes in different intermediate AMD patterns

Cited by 18 publications

References 41 publications

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography

Femto-assisted versus conventional phacoemulsification differently impact on choroid structure after surgery

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