Choroidal Neovascularization Secondary to Candida albicans Chorioretinitis

Jampol, Lee M.; Sung, Jennie; Walker, Jonathan D.; Folk, James C.; Townsend-Pico, William; Lowder, Careen Y.; Dodds, Emilio M.; Westrich, David; Terry, J E

doi:10.1016/s0002-9394(14)70630-0

Cited by 41 publications

(23 citation statements)

References 15 publications

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“…infiltrate the eyes via the bloodstream and may cause endophthalmitis and chorioretinitis in premature infants, 9 as well as choroidal neovascularization 2 weeks to 2 years after Candida albicans chorioretinitis in adults. 10 In 1998, Mittal et al 11 reported that Candida sepsis in ELBW neonates was significantly associated with severe ROP and a more than five-fold increase in the need for laser surgery; later on, this association was extended to all VLBW infants by Noyola et al 12 Other authors have also described a significant association between ROP and the concomitance of fungal sepsis plus either Caucasian race 13 or treatment with dexamethasone. 14 However, a larger series investigated by Karlowicz et al 8 indicated that candidemia may not be an independent risk factor for threshold ROP in ELBW infants, and that gestational age determines the association.…”

Section: Introductionmentioning

confidence: 99%

Fungal and bacterial sepsis and threshold ROP in preterm very low birth weight neonates

et al. 2005

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Objective: To determine whether an association exists between either fungal or bacterial sepsis and retinopathy of prematurity (ROP).Study Design: Retrospective cohort study on all neonates with birth weight <1500 g admitted to a large Italian third Level Neonatal Intensive Care Unit in the years 1997-2001 and screened for ROP. Univariate analysis and multiple logistic regression were used to detect significant associations with ROP (all grades and threshold) in neonates with birth weight <1000 g (extremely low birth weight (ELBW)) and 1000-1500 g. Results:Among 301 enrolled neonates, ROP (all grades), threshold ROP, fungal and bacterial sepsis occurred in 31.9, 12.9, 11.6 and 40.5% of the infants, respectively. At multivariate analysis, only gestational age (P ¼ 0.03), colonization by Candida non-albicans spp (P ¼ 0.03) and fungal sepsis (P ¼ 0.03) were independent predictors of threshold ROP, and only in ELBW neonates.Conclusions: Fungal (but not bacterial) sepsis is significantly and independently associated with ROP, but only in ELBW neonates and only with threshold ROP.

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Section: Introductionmentioning

confidence: 99%

Fungal and bacterial sepsis and threshold ROP in preterm very low birth weight neonates

et al. 2005

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“…These include direct or ischemic damage to the macula or the optic nerve, epiretinal membrane formation, vitreoretinal traction, or retinal detachment. [6] Candidal lesions are found in the inner choroid and may break through Bruch's membrane to form subretinalabcesses or involve full-thickness retina, and it is not surprising to see subretinal neovascularization, full-thickness retinal scar, and epiretinal membranes distorting the retinal surface even after successfully treatment of Candida retinitis. [7] Also, theepiretinal membrane may result from inflammation and vitreous traction associated with the candida endophthalmitis.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Only a few cases of epiretinal membrane secondary to candida have been previously reported [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Jampol et al [6] suggested that laser photocoagulation and surgical excision of the neovascular complex may be good option in selected cases with CNV secondary to candida chorioretinitis. Tedeshci et al [9] reported that photodynamic therapy is safe and useful to arrest CNV progression in the fovealresion for secondary choroidal neovascularization in candida endophthalmitis.…”

Section: Discussionmentioning

confidence: 99%

“…[3,4,5] However, choroidal neovascularization (CNV) or tractionalepiretinal membrane may follow successful treatment of candida endophthalmitis with subsequent visual loss. [6,7] A PubMed and Google search revealed no reported cases of secondary CNV accompanied by tractional posterior hyaloid membrane secondary to candida endophthalmitis, using spectral domain optical coherence tomography (SD-OCT). We report a case of CNV and tractional membrane secondary to Candida chorioretinitis using SD-OCT.…”

Section: Introductionmentioning

confidence: 99%

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Choroidal Neovascularization Accompanied by Tractional Posterior Hyaloid Membrane Secondary to Candida Chorioretinitis

Jung¹,

Kim²,

Kim³

2015

AJMCR

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A 62-year-old-male presented at our clinic with decreased vision and metamorphopsia(OD) for several days. He had received an anti-fungal treatment two months before for the treatment of endogenous candida choroiditis (OU). Fluorescein angiography and optical coherence tomography revealed subfoveal, juxtafoveal choroidal neovascularization and tractionalposterior hyaloidmembrane (OD). Pars planavitrectomy and epiretinal membrane removal was done, and twointravitrealbevacizumabinjections were administered. His visual symptoms were not improved and chorioretinal scar and fibrotic change were detected at fovea.

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