Choroidal neovascularization associated with coloboma of the choroid: A series of three cases

Abstract

Choroidal neovascularization (CNV) is a rare complication associated with coloboma of the choroid. We describe three cases of coloboma choroid where there was loss of vision due to CNV development at the edge of the coloboma. One was managed by photodynamic therapy alone and two were managed by a combination of reduced fluence PDT and intravitreal bevacizumab. Significantly we noted that one treatment session was sufficient to achieve regression of the CNV and improvement in visual acuity.

Demographic features of subjects with congenital glaucoma

“…Virtually, all previously published studies report bilateral disease between 70 and 80% in congenital glaucoma patients. [1459] Congenital glaucoma in this study is, however, observed in 92.3% of the patients. The frequency of unilateral disease in secondary congenital glaucoma was higher than in primary congenital glaucoma, probably owing to the more frequent observation of unilaterality in phakomatoses, and Peters anomaly.…”

“…[1] In the former classification method, congenital glaucoma is classified into primary or secondary congenital glaucoma. Primary congenital glaucoma, also known as isolated trabeculodysgenesis, is typically an isolated idiopathic developmental abnormality of the trabecular meshwork in the absence of other ocular and systemic conditions.…”

Familial exudative vitreoretinopathy in a patient with choroidal coloboma

“…An interaction of these genes may explain the coexistence of the FEVR with coloboma. CNV is a known rare complication associated with choroidal coloboma 5. This case highlights the occurrence of these two anomalies in a single patient which, to the best of our knowledge, has not been reported before.…”

Antivascular Endothelial Growth Factor Monotherapy for Choroidal Neovascularization Associated With Retinochoroidal Coloboma

“…[1][2][3][4] Choroidal neovascularization is a welldocumented complication of RCC in adults and children. 1,[8][9][10][11] Among the 9 cases reported in the literature (Table 2), the youngest child was a 19-month-old boy by Goodwin et al 8 Eight of these 9 patients reported progressive decrease of vision or metamorphopsia for at least 2 weeks. A history of retinal detachment was noted in 1 patient, the 5-year-old reported by Naithani et al 1 None of the patients had a history of prophylactic barrage laser.…”

“…Management options of coloboma-related CNVM are photocoagulation therapy, 8 photodynamic therapy (PDT) alone, 9,10 and antivascular endothelial growth factor (anti-VEGF) monotherapy 1 and in combination. 8 Here, we report 3 cases that were successfully treated with intravitreal bevacizumab (IVB) monotherapy, addressing the treatment protocol, outcome, and recurrence in eyes with CNVM associated with RCC.…”