Choroidal metastasis of a minor salivary gland adenoid cystic carcinoma: A case report

Blanco, Reinaldo; Martínez-Aguirre, I. Roberts; Méndez, P. Pontón; Martin, Michael; García, E. Pérez-Salvador

doi:10.1016/j.oftale.2018.05.008

Cited by 1 publication

(3 citation statements)

References 9 publications

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“…To the best of our knowledge, only nine cases of oral and salivary gland ACC developing distant metastasis more than 10 years after initial treatment have been reported in the literature (Table 1). [17][18][19][20][21][22][23][24][25] The mean age at primary treatment was 39 years (15-61 years), and the male-to-female ratio was 3:2. The most common location of the primary ACC was the submandibular gland (40%), followed by the parotid gland (20%), tongue, lower lip, gingiva, and sublingual gland (10%).…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15] Moreover, distant metastasis of ACC can occur after a long time interval without local recurrence. [16][17][18][19][20][21] Jaso and Editor: Maya Saranathan.…”

Section: Introductionmentioning

confidence: 99%

“…Distant metastasis can develop despite a favorable local control [13–15] . Moreover, distant metastasis of ACC can occur after a long time interval without local recurrence [16–21] . Jaso and Malhotra suggested that primary ACC and metastatic ACC should be treated as different lesions [14] .…”

Section: Introductionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment

et al. 2021

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Rationale: Adenoid cystic carcinoma (ACC) is a rare malignant tumor that primarily occurs in the salivary glands. Distant metastases can develop despite favorable local control. Moreover, distant metastasis of ACC can occur after a long time interval without local recurrence. We report the first case of ACC of the sublingual gland that developed lung metastasis 20 years after primary treatment. Patient concerns: A 52-year-old man was referred to our department with a 1-year history of painful swelling on the right oral floor. Diagnosis: An incisional biopsy was performed, and histopathological examination revealed malignancy. Interventions: Surgical excision of the right oral floor and right supra-omohyoid neck dissection with postoperative chemoradiation therapy were performed, and ACC of the sublingual gland was diagnosed. Left pulmonary metastasis was detected 20 years after the primary treatment. Metastasectomy was performed; however, subsequently, skin and bone metastases developed. Outcomes: After receiving palliative care, the patient died of multiple organ failure. Lessons: As late distant metastasis of salivary ACC can develop, patients who undergo primary treatment need a long-term, strict follow-up plan even if locoregional control is favorable.

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Section: Discussionmentioning

confidence: 99%

“…[13][14][15] Moreover, distant metastasis of ACC can occur after a long time interval without local recurrence. [16][17][18][19][20][21] Jaso and Editor: Maya Saranathan.…”

Section: Introductionmentioning

confidence: 99%