“…Proteases, including tryptase, MMPs, and granzyme B, disrupt extracellular matrix leading to the degradation of the choriocapillaris basement membrane, endothelial damage, and vascular dropout [ 12 ]. Moreover, choroidal mast cells are located near the choroidal vasculature, intervening in the modulation of angio-inflammatory processes [ 10 ]. Finally, mast cells through the secretion of TNF-α recruit neutrophils and macrophages, amplifying the inflammatory response.…”