Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography

Yeoh, Jonathan; Rahman, Waheeda; Chen, Fred K.; Hooper, Claire; Patel, Praveen J; Tufail, Adnan; Webster, Andrew R.; Moore, Anthony T.; daCruz, Lyndon

doi:10.1007/s00417-010-1437-3

Cited by 125 publications

(92 citation statements)

References 18 publications

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“…In a recent study of young Danish adults aged 20-29 years, the average SFCT was 344 mm. 6 Thus, our finding of a mean choroidal thickness of 327 mm in those aged [16][17][18][19] years suggests that choroidal thickness approaches the adult value at this age. Several cross-sectional studies in adults have clearly shown that choroidal thickness later decreases with advancing age; the mean decrease is 15-20 mm per decade in later life.…”

Section: Discussionmentioning

confidence: 65%

“…In high myopia, retinal dystrophy, and age-related choroidal atrophy, the choroid was reported to have decreased thickness, whereas increased choroidal thickness was reported in central serous chorioretinopathy and Vogt-Koyanagi-Harada disease. [15][16][17][18][19] Also, there is recent data on the hemodynamic effect of chemicals-sildenafil and nicotine-on choroid, obtained by OCT. 20,21 In our population of 160 patients aged 4-23 years, we found a mean SFCT of 308 mm with substantial variation between individuals, which was consistent with previous studies in adults. 4,22 Recent studies examining in vivo choroidal thickness with OCT in children have reported mean SFCT values of 348 mm (in 48 Korean children aged 4-10 years), 9 330 mm (in 194 children aged 4-12 years), 10 and 342 mm (in 174 children aged 3.5-15 years).…”

Section: Discussionmentioning

confidence: 99%

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Association of choroidal thickness with eye growth: a cross-sectional study of individuals between 4 and 23 years

Zengin

Karahan

Yılmaz

et al. 2014

Eye

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Association of choroidal thickness with eye growth: a cross-sectional study of individuals between 4 and 23 years

Zengin

Karahan

Yılmaz

et al. 2014

Eye

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“…Enhanced depth imaging (EDI) technology has led to a revolution in the study of deeper eye structures, such as the choroid and the LC. [4][5][6] It allows visualisation of the LC underneath the neuroretinal ring and provides high resolution images similar to those obtained by histology. This technique has been used to evaluate the LC in both normal and glaucomatous subjects.…”

Section: Introductionmentioning

confidence: 98%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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Aim To determine the response of the lamina cribrosa (LC) and prelaminar tissue to a reduction of intraocular pressure (IOP) after nonpenetrating deep sclerectomy (NPDS) using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods A total of 28 eyes from 28 patients presenting with primary open angle glaucoma who underwent NPDS were studied. SD-OCT scans using EDI technology were obtained before surgery and 1 week, 1 month, and 3 months postoperatively. The OCT device was set to image a 15 Â 101 vertical rectangle centred on the optic disc. The scan closest to the optic nerve head (ONH) centre was selected for analysis. The vertical distances from three equidistant points on the reference line (Bruch's membrane opening) to the anterior prelaminar tissue surface and the anterior and posterior surfaces of the LC were measured. Results The IOP decreased from 18.7 ± 4.3 to 9.1±4.0 at the first week, 11.4±3.7 at 1 month, and 13.1±3.6 mm Hg at 3 months postoperatively (Po0.001). There was a significant reduction of the ONH cupping at 1 week (22.3%, Po0.001), 1 month (13.7%, Po0.001), and 3 months (9.8%, P ¼ 0.001) after surgery. Anterior displacement of the LC was slight but statistically significant at 1 week (4.5%, P ¼ 0.003), 1 month (3.8%, P ¼ 0.014), and 3 months postoperatively (3.3%, P ¼ 0.010). IOP reduction was significantly correlated with a reduction of ONH cupping and anterior displacement of LC at the first week and first month (Po0.05). Conclusions Cupping reversal after NPDS is mainly due to changes in prelaminar tissue thickness, whereas the LC changes in position are less pronounced.

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Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] The new technology has lead to better understanding of the role of choroid in various macular diseases, including central serious chorioretinopathy, 9-11 high myopia, 12,13 Vogt-Koyanagi-Harada disease, 14 and a variety of retinal dystrophies. 15 However, although SD-OCT has been used to assess choroidal thickness in various diseases, including AMD, it has not yet been used to correlate choroidal thickness with drusen load in dry AMD.In addition to measuring choroidal thickness, SD-OCT can now be used to measure drusen load (area and volume). This novel diagnostic technology and algorithm was evaluated and showed the ability to generate highly reproducible qualitative and quantitative analysis of the drusen area and volume.…”

mentioning

confidence: 99%

Optical Coherence Tomography–based Correlation Between Choroidal Thickness and Drusen Load in Dry Age-Related Macular Degeneration

Cao

Pakzad-Vaezi

et al. 2013

Retina

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Purpose-Spectral domain optical coherence tomography can be used to measure both choroidal thickness and drusen load. The authors conducted an exploratory study using spectral domain optical coherence tomography to determine if a correlation between choroidal thickness and drusen load exists in patients with dry age-related macular degeneration.Methods-Forty-four patients with dry age-related macular degeneration were recruited. The drusen area and volume were determined using the automated software algorithm of the spectral domain optical coherence tomography device, and choroidal thickness was measured using enhanced depth imaging. Correlations were determined using multivariable and univariable analyses.Results-The authors found an inverse correlation between choroidal thickness and drusen load (r = −0.35, P = 0.04). Drusen load was also correlated with visual acuity (r = 0.32, P = 0.04). A correlation between choroidal thickness and visual acuity was suggested (r = −0.22, P = 0.21).Conclusion-Spectral domain optical coherence tomography can be used to assess the correlation between drusen load and choroidal thickness, both of which show a relationship with visual acuity. The measurement of these outcomes may serve as important outcome parameters in routine clinical care and in clinical trials for patients with dry age-related macular degeneration. Age-related macular degeneration (AMD) is one of the leading causes of vision loss in people over the age of 50 in the developed world. The role of the choroid in the pathogenesis and progression of dry AMD through the formation and accumulation of drusen deserves further investigation. The choroid provides the only circulation for the retinal pigment epithelium (RPE) and outer retina. Therefore, it is the primary means of metabolic support for these tissues. 1 It has been shown that the choriocapillaris has unique features including high flow rate and low oxygen extraction that are mandatory to sustain normal photoreceptor metabolism. 3 Hence, the choroid's critical role of metabolic support for the retina and RPE suggests that this vascular layer may have a role in drusen development. In other words, RPE with poor metabolic support secondary to deficient choroidal supply may be more prone to developing drusen as they are unable to completely metabolize photoreceptor byproducts. 4,5 Spectral domain optical coherence tomography (SD-OCT) is a relatively new technology that allows detailed imaging within the retina, including the photoreceptor layer and RPE, as well as the choroid. 6 High-definition SD-OCT has previously been used to measure choroidal thickness in AMD. 7 It has been demonstrated that enhanced depth imaging (EDI) SD-OCT, which produces an inverted image from 100 scans to improve signal-to-noise ratio, can be used to visualize the choroid even better. [8][9][10][11] The new technology has lead to better understanding of the role of choroid in various macular diseases, including central serious chorioretinopathy, 9-11 high myopia, 12,13 Vogt-Koy...

show abstract

Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography

Cited by 125 publications

References 18 publications

Association of choroidal thickness with eye growth: a cross-sectional study of individuals between 4 and 23 years

Association of choroidal thickness with eye growth: a cross-sectional study of individuals between 4 and 23 years

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Optical Coherence Tomography–based Correlation Between Choroidal Thickness and Drusen Load in Dry Age-Related Macular Degeneration

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