Choroidal circulation in diabetic patients

Dimitrova, Galina; Kato, Satoshi; Tamaki, Yasuhiro; Yamashita, Hidetoshi; Nagahara, Miyuki; Sakurai, Masaki; Kitano, Shigehiko; Fukushima, Harumi

doi:10.1038/eye.2001.193

Cited by 78 publications

(68 citation statements)

References 23 publications

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“…Several investigations suggest that DM affects choroidal vasculatures as well as retinal vessels [30,31]. Choroidopathy in patients with DM includes obstruction and/or dropout of the choriocapillaris, increased formation of vascular loops, microaneurysms, vascular remodeling, intrachoroidal neovascularization, and subsequent impaired choroidal circulation [32][33][34][35][36][37][38][39][40]. In patients with DM, underlying DM choroidopathy can affect the choroidal changes after HD.…”

Section: Discussionmentioning

confidence: 99%

Changes in Choroidal Thickness after Hemodialysis and the Influence of Diabetes

Kang

Choi²,

Kim

et al. 2017

J Retin

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Purpose:To evaluate the changes in subfoveal choroidal thickness (SFCT) after hemodialysis (HD) and to investigate the possible impact of diabetes mellitus (DM). Methods: This prospective, interventional case series included 18 patients undergoing HD due to chronic renal failure. Mean SFCT was measured before (pre-HD) and after HD (post-HD), and the differences (ΔSFCT) were calculated for each eye. In addition, the ratio of SFCT change (%SFCT; ΔSFCT/baseline SFCT × 100, percent, %) was calculated. Results: Ten patients (55.6%) had DM as the underlying etiology for HD. The mean SFCT was 311.8 ± 64.9 μm (177.5-468.0 μm) pre-HD and 311.2 ± 65.1 μm (191.5-454.5 μm) post-HD (p = 0.877). The mean ΔSFCT was -4.4 ± 20.0 μm (-64.0 to 29.0 μm), and the mean %SFCT was 4.3 ± 4.4% (0 to 19.5%). The mean ΔSFCT was significantly larger in patients with DM than those without DM (-14.1 ± 18.2 μm and 7.8 ± 15.6 μm; p = 0.006), but the mean %SFCT was not significantly different between the groups (4.4 ± 5.5% and 4.2 ± 2.6%; p = 0.315). Conclusions:The mean SFCT was not significantly changed after HD. The change in mean SFCT was significantly larger in patients with DM than in those without.

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Section: Discussionmentioning

confidence: 99%

Changes in Choroidal Thickness after Hemodialysis and the Influence of Diabetes

Kang

Choi²,

Kim

et al. 2017

J Retin

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“…5,8,19,20 In non-proliferative and in proliferative diabetic retinopathy the reduction of blood flow velocity and the increase of the indices of resistivity was most evident in the central retinal, 1,5,11,12,13,15,17 but also in the short posterior 8,17 and in the ophthalmic arteries. 8,14,17 [27][28][29][30] and fellow eyes. [31][32][33][34] It has also been suggested that a characteristic decrease in the blood flow velocity in the central retinal vein was highly predictive of iris neovascularisation.…”

Section: Colour Doppler Imaging In Diabetic Retinopathymentioning

confidence: 99%

“…Most of those studies concerned the ocular blood circulation in diabetes. 1,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] A number of studies reported that altered retrobulbar blood flow parameters are already present in patients without diabetic retinopathy. 5,8,15,[19][20][21] The blood flow velocity in the central retinal artery in diabetic patients without diabetic retinopathy was significantly decreased than in control subjects.…”

Section: Colour Doppler Imaging In Diabetic Retinopathymentioning

confidence: 99%

“…1,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] A number of studies reported that altered retrobulbar blood flow parameters are already present in patients without diabetic retinopathy. 5,8,15,[19][20][21] The blood flow velocity in the central retinal artery in diabetic patients without diabetic retinopathy was significantly decreased than in control subjects. 5,8,19,20 In non-proliferative and in proliferative diabetic retinopathy the reduction of blood flow velocity and the increase of the indices of resistivity was most evident in the central retinal, 1,5,11,12,13,15,17 but also in the short posterior 8,17 and in the ophthalmic arteries.…”

Section: Colour Doppler Imaging In Diabetic Retinopathymentioning

confidence: 99%

“…5,8,15,[19][20][21] The blood flow velocity in the central retinal artery in diabetic patients without diabetic retinopathy was significantly decreased than in control subjects. 5,8,19,20 In non-proliferative and in proliferative diabetic retinopathy the reduction of blood flow velocity and the increase of the indices of resistivity was most evident in the central retinal, 1,5,11,12,13,15,17 but also in the short posterior 8,17 and in the ophthalmic arteries. 8,14,17 [27][28][29][30] and fellow eyes.…”

Section: Colour Doppler Imaging In Diabetic Retinopathymentioning

confidence: 99%

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Colour Doppler Imaging of Ocular and Orbital Blood Vessels in Retinal Diseases

Dimitrova¹

2011

European Ophthalmic Review

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ImagingColour Doppler Imaging (CDI) is an established method for investigation of the ocular and orbital blood flow characteristics. It is an ultrasonographic method that has been employed for the evaluation of the circulatory status in much ocular pathology, but is most used for the investigation of the circulatory status in retinal vascular disorders and in glaucoma. [1][2][3] Ultrasound imaging (sonography) is accomplished with a pulse-echo technique. Pulses of ultrasound (generated by a transducer) are sent into the patient where they produce echoes at organ boundaries and within tissues. These echoes then return to the transducer, they are being detected and then displayed. Colour-flow imaging extends the use of the pulse-echo imaging principle. Echoes returning from stationary tissues are detected and presented in greyscale in appropriate locations along the scan line. The depth is determined by the echo's arrival time and the brightness is determined by the echo's amplitude. If a returning echo has a different frequency than what is emitted a frequency change has occurred because the echo-generating object was moving. If the motion is towards or away from the transducer, the Doppler shift is positive or negative, respectively. Along with the transducer, the colour-flow instrument consists of a pulser, a beam-former, a receiver, a memory and a display (see Figure 1).In ophthalmology, CDI is most often used to study the circulatory parameters in the retrobulbar blood vessels -the central retinal artery, central retinal vein, ophthalmic artery and the short and long posterior ciliary arteries. However, intraocular blood vessels have also been studied, such as vortex veins, blood vessels in the intraocular tumours, in detached retina, etc. The measurement is usually obtained through closed eyelids in a supine or in a seated position. Nagahara et al.patented a device for CDI measurement in seated subjects that increased the reproducibility of the measurement by 50% (see Figure 2). 4 The reflected ultrasound from the moving cells in the measured blood vessels is recorded by the CDI device and represented as a velocity wave. Two such velocity waves from the central retinal artery and the central retinal vein are presented in Figure 3.Several blood flow parameters can be obtained from the velocity wave, such as peak systolic blood velocity (PSV), end-diastolic blood velocity (EDV), mean blood velocity (MV), resistivity index (RI) and pulsatility index (PI): RI is calculated as (PSV-EDV)/PSV; PI is calculated as (PSV-EDV)/MV.Although the CDI device is equipped for measurement of blood vessel diameter, the dimension of the retrobulbar blood vessels is too small to obtain a reliable estimation of their diameter. Therefore, total blood flow cannot be evaluated in the retrobulbar blood vessels using CDI.The recording of the blood flow parameters of the central retinal artery and vein is obtained inside the optic nerve, a few millimetres away from the lamina cribrosa (see Figure 3). A specific finding of the blood flo...

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