Choroidal calcification in primary hyperparathyroidism

O'Driscoll, A; Quraishy, Muhammad Muneer; Andrew, N C

doi:10.1038/eye.1995.201

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Ocular changes are common in various endocrine disorders, such as diabetes mellitus (DM) and Graves' disease (GD). Nonetheless, there are limited data from previous studies of ocular changes in patients with PHPT, and there are presently fewer patients with ocular and choroidal calcifications than previously reported [4][5][6]. It is rare to encounter such symptoms, because most patients with PHPT are diagnosed during the asymptomatic stage.…”

Section: Introductionmentioning

confidence: 72%

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Is there any association between primary hyperparathyroidism and ocular changes, such as central corneal thickness, retinal thickness, and intraocular pressure?

Başer¹,

Çuhacı

Topaloğlu

et al. 2015

Endocrine

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Ocular changes are commonly encountered in various endocrine disorders. However, only a few studies have reported ocular changes in patients with primary hyperparathyroidism (PHPT). Here, we examined the central corneal thickness (CCT), retinal thickness (RT), and intraocular pressure (IOP), and their relationships with serum intact parathyroid hormone (iPTH), calcium (Ca), and phosphorus (P) levels in patients with PHPT. Thirty-seven eyes of 37 PHPT patients were compared with 43 eyes of 43 age- and sex-matched normal subjects. A detailed ophthalmologic examination, including CCT, RT, and IOP, was performed. CCT and IOP in PHPT patients were significantly higher than controls (p = 0.024 and p = 0.038, respectively). No statistically significant difference was detected in RT between the two groups (p = 0.730). iPTH levels were positively correlated with CCT and IOP (r = 0.304, p = 0.006 and r = 0.249, p = 0.026, respectively). No significant correlation was found between iPTH levels and RT (p > 0.05), and between serum Ca levels, and RT, CCT, and IOP (all, p > 0.05). While there was a negative correlation between serum P levels and CCT (r = -0.264, p = 0.018), no correlation was observed between serum P levels, and RT and IOP (both, p > 0.05). Using multiple regression analyses, iPTH, serum Ca, and serum P levels were found to have no significant associations with CCT, IOP, and RT (all, p > 0.05). There was no significant association between PHPT, and CCT, RT, and IOP. We postulate that the identification of ocular aspects of PHPT is significant, and further studies related to this condition are required.

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Section: Introductionmentioning

confidence: 72%

“…The crystals in epithelial cells were often restricted to the nucleus [7]. In previous reports, there have been a limited number of PHPT cases with choroidal neovascularization, and ocular and sclerochoroidal calcifications (SCC) [4][5][6]. The SCC seen in these cases might be associated with systemic hypercalcemia [4].…”

Section: Discussionmentioning

confidence: 99%

Is there any association between primary hyperparathyroidism and ocular changes, such as central corneal thickness, retinal thickness, and intraocular pressure?

Başer¹,

Çuhacı

Topaloğlu

et al. 2015

Endocrine

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Sklerochoroidale Kalzifikationen mit subretinaler neovaskulärer Membran bei einem Patienten mit hoher Myopie

Zuercher

Zografos

2002

Der Ophthalmologe

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The diagnosis of sclerochoroidal calcifications should be complemented with angiographic investigations because of a possible association with a subretinal neovascular membrane. In two such cases reported previously in the literature, the neovascular membrane was treated by laser coagulation. In one case, as in ours, no treatment was undertaken. The good prognosis of sclerochoroidal calcifications remained unaltered in all cases.

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