Choroidal Biopsies for Intraocular Tumors of Indeterminate Origin

Kvanta, Anders; Seregard, Stefan; Kopp, Eva Dafgård; All-Ericsson, Charlotta; Landau, Irène; Berglin, Lena

doi:10.1016/j.ajo.2005.06.025

Cited by 61 publications

(48 citation statements)

References 14 publications

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“…Fine-needle aspiration biopsy (FNAB) has been used in a number of ophthalmic centers since the late 1970s and early 1980s as an ancillary diagnostic tool in selected cases of suspected primary uveal melanoma (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) . In most of these early cases, the objective of the FNAB was to establish, confirm, or refute the clinical diagnosis of the evaluated intraocular tumor and direct baseline systemic evaluation of the patient, treatment of the primary intraocular tumor, and post-treatment follow-up (1,4,5,9,(13)(14)(15) .…”

Section: Introductionmentioning

confidence: 99%

Prognostic implications of cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy

Augsburger¹,

Corrêa²,

Trichopoulos³

2013

Arq. Bras. Oftalmol.

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Purpose: Determine whether cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy (FNAB) is a significant prognostic factor for death from metastasis. Methods: Retrospective analysis of cases of clinically diagnosed uveal melanoma evaluated by fine-needle aspiration biopsy from 1980 to 2006. Main outcome evaluated was death from metastasis. Associations between baseline clinical variables and cytopathologic classification were evaluated using cross-tabulation. Prognostic significance of cytopathologic classification was evaluated by Ka planMeier and Cox proportional hazards analysis. Results: Of 302 studied biopsies, 260 (86.1%) yielded sufficient cells for cytopathologic classification. Eighty of the 260 patients who had a sufficient specimen have already died (P=0.021), 69 from metastatic uveal melanoma. Cell type assigned by cytopathology was strongly associated with metastasis/metastatic death in this series (P=0.0048). Multivariate analysis showed cytopathologic classification to be an independently significant prognostic factor for metastatic death (P=0.0006). None of the 42 patients whose tumor yielded insufficient aspirates (sampled in at least two sites) have developed metastasis or died of metastasis thus far. Conclusion: In this series, cytopathology of fine-needle aspiration biopsy samples obtained from uveal melanomas was strongly prognostic of death from metastasis. Insufficiently aspirates (2 or more sites sampled) proved to be prognostic of a favorable outcome (i.e., not developing metastasis). Keywords

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Section: Introductionmentioning

confidence: 99%

Prognostic implications of cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy

Augsburger¹,

Corrêa²,

Trichopoulos³

2013

Arq. Bras. Oftalmol.

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“…2 However, a biopsy of intraocular tissues is generally not performed because of the risk of visual complications. 4 In addition, the intraocular tissues obtained are usually very small which makes it difficult to examine them by histological sections.…”

Section: Discussionmentioning

confidence: 99%

Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting diagnosis

Ogata

Matsuoka

Adachi

et al. 2010

Acta Ophthalmologica

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Abstract:The purpose of this paper is to report two cases of sarcoidosis with conflicting signs in which vitreous cytology was useful for supporting the diagnosis. Case 1 was a 56-year-old man who was referred with blurred vision, and was found to have iridocyclitis, vitreous opacities, and optic neuritis bilaterally. He also had a swelling of both mandibular glands. He received pulsed corticosteroid therapy, but the vitreous opacities and papilledema did not resolve. The second case was a 77-year-old man referred with blurred vision, and both eyes had snowballlike vitreous opacities and optic neuritis. The ocular findings in both cases strongly suggested sarcoidosis, but the systemic findings did not meet the diagnostic criteria for sarcoidosis. We performed pars plana vitrectomy to remove the vitreous opacities, and the collected vitreous samples were sent for cytological analyses. Epithelioid and multinucleated giant cells pathognomonic of sarcoidosis were found in the vitreous samples which enabled us to make a diagnosis of sarcoidosis. Vitreous cytology can help in supporting a diagnosis of sarcoidosis, especially in cases of ocular inflammation suggesting sarcoidosis but systemic findings that do not satisfy the diagnostic criteria for this disease.

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“…Nevertheless, one suspected clinical case of extrascleral recurrence has recently been reported after diagnostic intraocular transscleral FNAB [9]. Therefore concern about tumor seeding due to this diagnostic procedure still exists [10], and FNAB is consequently not used routinely yet.…”

Section: Introductionmentioning

confidence: 99%

Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker

Filali

Kılıç

Melis

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Introduction Uveal melanoma (UM) cells and neurohormone-producing cells both originate from the neural crest. Somatostatin receptors subtype 2 (SSTR2) are overexpressed in several tumors, often from neuroendocrine origin, and synthetic antagonists like octreotide and octreotate are being used as diagnostic or therapeutic agents. We investigated the SSTR2 expression in UM, and determined whether this expression was related to prognosis of the disease. Materials and methods UM cell lines and fresh primary UM samples were tested for SSTR2 expression by autoradiography (AR) using 125I-Tyr3-octreotate. Furthermore, UM cell lines were analyzed for SSTR2 mRNA expression with quantitative real-time RT-PCR. Results Using AR, cell-surface SSTR2 expression was demonstrated in two UM metastatic cell lines, but no expression was detected in three cell lines derived from primary UM. However, all primary and metastatic UM cell lines showed mRNA expression levels for SSTR2 using quantitative real-time RT-PCR. Only three of 14 primary UM demonstrated moderate SSTR2 expression, and this expression was not significantly associated with tumor-free survival or any tested prognostic factor. Conclusions Based on the rare and low expression of SSTR2 found in primary UM specimens and in UM cell lines, we conclude that SSTR2 is not widely expressed in UM. Furthermore, SSTR2 expression was not associated with tumor-free survival and prognostic factors. Therefore SSTR2 is not suited as prognostic marker or therapeutic target in UM.

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Choroidal Biopsies for Intraocular Tumors of Indeterminate Origin

Cited by 61 publications

References 14 publications

Prognostic implications of cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy

Prognostic implications of cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy

Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting diagnosis

Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker

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