Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retinopathy

Yolcu, Ümit; Çağıltay, Eylem; Toyran, Sami; Akay, Fahrettin; Uzun, Salih; Gündoğan, Fatih Ç.

doi:10.1080/00325481.2016.1210475

Cited by 20 publications

(18 citation statements)

References 26 publications

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“…The measurements of PFT and PFV, albeit of secondary importance to our study, appear interesting and require further research in a larger number of eyes. In the present study, pubescent youths with T1D presented with significantly fewer objective signs of retinal and choroidal structure impairment than diabetic adults as previously reported [ 10 – 13 , 36 – 38 , 41 ]. We are hoping to continue the follow-up of these young patients to monitor the status of their retinas and choroids.…”

Section: Discussionsupporting

confidence: 77%

“…Pierro et al found decreased GCC and choroidal thickness only in patients with T2D, not T1D and suggested that insulin resistance might be one of the causes of neurodegeneration [ 41 ]. Most reports reveal that the retina becomes thinner in DR [ 13 , 22 , 40 ]. We confirm these results, as there were significant differences in PFT and PFV between the groups.…”

Section: Discussionmentioning

confidence: 99%

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Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography

Gołębiewska

Olechowski

Wysocka‐Mincewicz

et al. 2018

Journal of Diabetes Research

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Aim To assess the retinal and choroidal thickness and ganglion cell complex (GCC) in pubescent children with type 1 diabetes (T1D) without diabetic retinopathy (DR), using spectral domain optical coherence tomography (SD-OCT). Materials and Method Sixty-four right eyes of 64 subjects with T1D and 45 right eyes of 45 age-matched healthy volunteers (control group) were enrolled in this study. The mean age of the subjects and controls was 15.3 (±SD = 2.2) and 14.6 (±SD = 1.5), respectively. SD-OCT was performed using RTVue XR Avanti. Ganglion cell complex (GCC), GCC focal loss volume (FLV), GCC global loss volume (GLV), choroidal thickness (CT), foveal (FT) and parafoveal thickness (PFT), and foveal (FV) and parafoveal volume (PFV) data were analyzed. Results There was no significant difference between subjects and controls in the CT in the fovea and nasal, temporal, superior, and inferior quadrants of the macula. There were no significant correlations between CT, duration of diabetes, and HbA1C level (p = 0.272 and p = 0.197, resp.). GCC thickness did not differ significantly between the groups (p = 0.448), but there was a significant difference in FLV (p = 0.037). Significant differences between the groups were found in the PFT and PFV (p = 0.004 and p = 0.005, resp.). There was a significant negative correlation between PFT, PFV, and HbA1C level (p = 0.002 and p = 0.001, resp.). Conclusions Choroidal thickness remains unchanged in children with T1D. Increased GCC FLV might suggest an early alteration in neuroretinal tissue. Parafoveal retinal thickness is decreased in pubescent T1D children and correlates with HbA1C level. OCT can be considered a part of noninvasive screening in children with T1D and a tool for early detection of retinal and choroidal abnormalities. Further OCT follow-up is needed to determine whether any of the discussed OCT measurements are predictive of future DR severity.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography

Gołębiewska

Olechowski

Wysocka‐Mincewicz

et al. 2018

Journal of Diabetes Research

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“…In the present study as well, we determined that the choroid is thinner in the nasal quadrant in both groups. In a study conducted by Yolcu et al in 60 healthy subjects and 60 type 1 DM patients with no retinopathy, the choroidal thickness was found to become thinner in the subfoveal nasal 1500µm and temporal 1500µm quadrants in type 1 diabetes patients, but no difference was determined between the groups for the other quadrants (13). Querques et al found no difference between the diabetic groups of different stages in terms of change in subfoveal choroidal thickness but reduced subfoveal choroidal thickness in diabetic groups vs the control group (14).…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Subfoveal Choroidal Thickness Using Spectralis Oct in the Patients With Type 1 Diabetes Mellitus

Eroğul¹,

Eroğul²

2019

Kocatepe Tıp Dergisi

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Bu çalışmada amacımız, endokrin kliniğince tip 1 diyabetes mellitus (DM) tanısı konulmuş herhangi bir diyabetik retinopati (DR) bulgusu olmayan olgularla, sağlıklı bireylerin koroid tabakası kalınlıklarını karşılaştırmaktır. GEREÇ VE YÖNTEM: Olguların spektral domain optical chorence tomografi cihazı (Nidek SLO/Spectral OCT(RS 3000))ile horizontal düzlemde taraması yapıldı. Koroid kalınlıklarını foveada, nazal ve temporalde horizontal olarak 600µm aralıklarla 1200 µm mesafaye kadar toplam 7 noktada ölçümler yapıldı. Tip 1 diyabet olan hastalar grup 1, kontrol grubu ise grup 2 olarak sınıflandırıldı. Korneal opasite, katarakt, retinal hastalık, ailede glokom ve oküler cerrahi öyküsü, kontrolsüz hipertansiyon, kardiyovasküler bozukluk olan hastalar çalışmaya dahil edilmedi.

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“…Choroidal thickness (CT) is considered a measure of choroidal blood flow, which supplies the outer retinal layers. Several studies have described the presence of choroidal vasculopathy in diabetic subjects [9,13,14,15,16]. However, those studies—most of which were performed in a paediatric population—have reported contradictory findings, likely due to their small sample sizes.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study

Carbonell

Alonso

Castelblanco

et al. 2019

JCM

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Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To assess the inner retinal and choroidal structural changes in type 1 diabetic subjects (T1D), a cross-sectional study was conducted in 242 T1D patients and in 69 age-matched, non-diabetic individuals. The nasal retinal nerve fibre layer (RNFL) thickness was lower in T1D patients without DR (p < 0.001), with mild DR (p < 0.001), and with advanced DR (p < 0.001) compared to control subjects. The ganglion cell layer (GCL) thickness was lower in T1D patients with advanced DR compared to those with mild DR (p = 0.003) and without DR (p < 0.001) and compared to the control subjects (p < 0.001). T1D subjects with no DR and mild DR had higher CT than the control subjects, but the CT in T1D patients with advanced DR was lower (p = 0.038) than that in T1D subjects with mild DR and was not significantly different from that of the control subjects. In conclusion, T1D subjects showed a significant thinning of the nasal RNFL in the early stages of the disease, even before any vascular changes in the retina. A decrease in the GCL thickness during advanced DR stages was observed. Choroidal thickness was higher in T1D subjects without DR and in early DR stages but decreased in advanced stages.

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Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retinopathy

Cited by 20 publications

References 26 publications

Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography

Choroidal Thickness and Ganglion Cell Complex in Pubescent Children with Type 1 Diabetes without Diabetic Retinopathy Analyzed by Spectral Domain Optical Coherence Tomography

Evaluation of Subfoveal Choroidal Thickness Using Spectralis Oct in the Patients With Type 1 Diabetes Mellitus

Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study

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