Choroid plexus-ventricular wall separation in fetuses with normal-sized cerebral ventricles at sonography: postnatal outcome.

Hertzberg, Barbara S.; Lile, R.; Foosaner, D. E.; Kliewer, Mark A.; Paine, Susan; Paulson, Erik K.; Carroll, Brianne; Bowie, J D

doi:10.2214/ajr.163.2.7518643

Cited by 25 publications

(24 citation statements)

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“…Additionally, we determined the area of the choroid plexuses relative to that of the ventricles, because an early sign of ventriculomegaly during the second trimester of pregnancy is apparent shrinkage of the choroid plexuses. Previous studies reported that at 14–21 weeks' gestation the choroid plexus normally fills the lateral cerebral ventricle from side to side7 and that, with development of ventricular dilatation, the choroid plexus separates from the medial wall of the lateral ventricle8, 9. A previous study from 14 weeks' gestation onwards established a normal range for the ratio of occipital horn height to choroid plexus thickness and reported that it was above the 95 th centile in 31 of 32 cases of confirmed ventriculomegaly10.…”

Section: Discussionmentioning

confidence: 96%

Physical function and health‐related quality of life of Spanish patients with ankylosing spondylitis

Ariza‐Ariza¹,

Hernández‐Cruz²,

Navarro‐Sarabia³

2003

Arthritis & Rheumatism

106

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Section: Discussionmentioning

confidence: 96%

Physical function and health‐related quality of life of Spanish patients with ankylosing spondylitis

Ariza‐Ariza¹,

Hernández‐Cruz²,

Navarro‐Sarabia³

2003

Arthritis & Rheumatism

106

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“…126 Ventriculomegaly is suspected when the atrial diameter reaches 10 mm, although separation of the dependent choroid from the medial ventricular wall may be visible evidence of early ventricular dilatation. 127 Mild ventricular dilatation deserves comment because it has been associated with trisomy 21 as well as other aneuploidies. [128][129][130] Although some authors 40,41 have categorized it as a major abnormality, we think it shares similar characteristics (nonspecific, common in normal fetuses, and often transient) 131 with other minor markers.…”

Section: Mild Ventricular Dilatationmentioning

confidence: 99%

Sonographic markers of fetal trisomies: second trimester.

Nyberg

Souter

2001

J of Ultrasound Medicine

110

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Objective. Second-trimester sonographic findings of fetal trisomy may include structural abnormalities or sonographic markers of fetal aneuploidy. Unlike structural anomalies, sonographic markers of fetal aneuploidy are insignificant by themselves with regard to outcome, are nonspecific-most frequently seen in normal fetuses, and are often transient. Our objective was to review the secondtrimester sonographic findings of the major trisomic conditions, trisomies 13, 18, and 21. Methods. We reviewed a number of the most commonly accepted markers, including nuchal thickening, hyperechoic bowel, echogenic intracardiac focus, renal pyelectasis, shortened extremities, mild cerebral ventricular dilatation, and choroid plexus cysts. Markers associated with trisomy 21 were emphasized. Results. The sensitivity of sonography for detection of fetal trisomic conditions varies with the type of chromosome abnormality, gestational age at the time of sonography, reasons for referral, criteria for positive sonographic findings, and the quality of the sonography. As an estimate, 1 or more sonographic findings can be identified in approximately 90% of fetuses with trisomy 13, 80% of fetuses with trisomy 18, and 50% to 70% of fetuses with trisomy 21 (Down syndrome). Conclusions. The presence or absence of sonographic markers can substantially modify the risk of fetal Down syndrome and is the basis of the so-called genetic sonogram. Because maternal biochemical and sonographic markers are largely independent, combined risk estimates will result in even higher detection rates than either alone.

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“…4 Separation of the choroid from the medial ventricular wall by 3 mm or greater ( Figure 2) has been associated with an abnormal outcome. [5][6][7] Prior studies on this finding have shown an association with trisomy 21 and developmental problems. These studies, however, have not detailed the natural history of choroid plexus separation or completely excluded cases with other sonographic findings.…”

mentioning

confidence: 63%

“…Hertzberg et al 6 reported on 74 cases of choroid separation, excluding fetuses with ventriculomegaly (atrial width >10 mm). In 58 of these cases, the choroid separation was an isolated finding.…”

Section: Discussionmentioning

confidence: 99%

Isolated Choroid Plexus Separation on Second‐Trimester Sonography

Bronsteen

Lee

Vettraino

et al. 2006

J of Ultrasound Medicine

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Objective. This study was undertaken to investigate the natural history and clinical importance of choroid plexus separation (a ≥3 mm distance between the choroid plexus and medial wall of the lateral ventricle) as an isolated finding in the second trimester. Methods. This was a 5-year retrospective review of an ultrasound database, looking for singleton fetuses with a menstrual age of 16 to 26 weeks and a finding of isolated choroid plexus separation. Results. There were 78 cases available for study. The finding of choroid plexus separation was usually transient. Resolution was noted in 37% of the cases that were rescanned within 2 weeks and 71% of the cases that were rescanned more than 2 weeks after the initial diagnosis. Two abnormal karyotypes (trisomy 21 and 47,XXY) and 3 cases with abnormal development not associated with an abnormal karyotype were noted on neonatal followup. Cases with abnormal development were quite varied in their presentation. Conclusions. The finding of isolated choroid plexus separation is usually temporary, resolving in most cases within 4 weeks of the initial diagnosis. Most infants with this finding have no abnormalities. The clinical implication of the lone case of trisomy 21 was limited by a major preexisting risk in this patient. The 3 cases of abnormal development had varying presentations; the causal nature of this association is not yet clear. No trends were noted between the changing choroid plexus appearance with time and abnormal neonatal outcome, but the number of abnormal cases was quite limited.

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Choroid plexus-ventricular wall separation in fetuses with normal-sized cerebral ventricles at sonography: postnatal outcome.

Cited by 25 publications

References 0 publications

Physical function and health‐related quality of life of Spanish patients with ankylosing spondylitis

Physical function and health‐related quality of life of Spanish patients with ankylosing spondylitis

Sonographic markers of fetal trisomies: second trimester.

Isolated Choroid Plexus Separation on Second‐Trimester Sonography

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