Choroid plexus papilloma of the cerebellopontine angle: a twelve patient series

Talacchi, Andrea; Micheli, Enrico De; Lombardo, Cristina; Turazzi, S.; Bricolo, Albino

doi:10.1016/s0090-3019(99)00024-5

Cited by 69 publications

(66 citation statements)

References 26 publications

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“…As a result, we recommend limiting the resection to avoid neurologic injury. Overall, the incidence of complications observed in our study compares favorably with other published studies [5,7,9,11], particularly those including patients treated in the pre-microsurgical era [6,12,13], in which perioperative mortality was high, especially in children [14][15][16][17][18][19]. Compared to published series from the modern microsurgical era, our observed morbidity and mortality were very minimal, once again confirming that these tumors can be safely resected in both children and adults [2,3,5,9,11].…”

Section: Discussionsupporting

confidence: 84%

“…Although there are reports of radiation therapy for residual tumor [4,5] or as a neoadjuvant treatment to shrink large lesions preoperatively [6], the indolent nature of these lesions suggests that observation of residual disease may be most appropriate. Most authors agree that radiation should be reserved for recurrent or malignant lesions, even in cases of STR, and certainly not in children less than 3 years of age [2,[7][8][9]. This is supported by our data, which demonstrated stable disease in all but one patient who underwent STR alone, with a mean follow-up time of over 10 years.…”

Section: Discussionsupporting

confidence: 82%

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Surgical outcomes in choroid plexus papillomas: an institutional experience

et al. 2013

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Choroid plexus papillomas (CPPs) are rare, indolent lesions that comprise less than 0.5 % of intracranial tumors. We sought to assess the long-term outcomes and associated surgical complications at our institution. A review of the University of California, San Francisco (UCSF) Brain Tumor Research Center (BTRC) database was performed to identify a cohort of patients treated for CPP from 1997 to 2011. Patients were grouped based on tumor location and extent of resection. Outcomes including progression-free survival and surgical complications were assessed. We identified 24 patients (16 female, 8 male) ranging in age from 6 months to 55 years (median 29 years) treated at our institution. Tumors were found in the following locations: 16 (67 %) fourth ventricle/cerebellopontine angle; 7 (29 %) lateral ventricle; 1 (4 %) third ventricle. Gross total resection (GTR) was achieved in 20 patients (83 %) with subtotal resection (STR) in 4 (17 %). Median follow-up time was 2.8 years with 3 recurrences identified at 1.6, 3.3, and 8.5 years. Extent of resection and tumor location were not associated with recurrence. There was one new permanent neurologic deficit detected after surgery. All patients were alive at most recent follow-up. Attempted gross total resection is the standard treatment for CPPs and generally associated with excellent outcomes. Since recurrences are rare, even among patients who undergo STR, radiation may be reserved for cases of tumor progression. This modern experience at a tertiary care center performed exclusively during the MRI-era demonstrates that CPPs can be safely removed with minimal morbidity and good tumor control.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 82%

Surgical outcomes in choroid plexus papillomas: an institutional experience

et al. 2013

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“…CPPs are also characterized by significant vessel hyperplasia under the microscope (24). However, certain CPPs are not accompanied by hydrocephalus, regardless of the size of the tumor (4,23,25). In our study, extraventricular CPPs without hydrocephalus were observed in four patients.…”

Section: Discussionmentioning

confidence: 99%

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Shi

Chen

et al. 2016

Oncology Letters

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Abstract. Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were retrospectively observed. The mass site, size, contour, signal intensity, cystic or solid appearance, calcification, capsules, degree and pattern of enhancement, and hydrocephalus were evaluated based on CT or MRI. The misdiagnosis rate of CPPs in extraventricular sites was 80.0% (8/10). Solitary masses and multiple masses were observed in nine patients (90.0%, 9/10) and one patient (10%, 1/10), respectively. In addition to the typical imaging findings [a lobulated, cauliflower-like or mulberry-like mass that is homogeneous isointense or slightly hypointense on T1-weighted imaging (T1WI) and heterogeneous isointense or slightly hyperintense on T2WI], four masses had round or oval contours and three had cystic components; abnormal signal intensity (mixed hyperintense signals on T1WI and T2WI or slightly hyperintense signals on T1WI or hypo-/hyperintense on T2WI) and low or no enhancements were observed in three and six masses, respectively; absence of hydrocephalus and mild or local hydrocephalus were each observed in four subjects, respectively. Hemorrhage and psammomatous bodies and/or calcification were observed in four and three masses, respectively. In conclusion, in addition to the typical imaging findings, atypical imaging findings, including atypical contours, abnormal signal intensity, low enhancement and absence of hydrocephalus were also observed in extraventricular CPPs.

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“…brain-stem), florid vascularity, and capacity for local invasion into underlying brain parenchyma (Krishnan et al, 2004). Furthermore, microsurgery-related permanent complications are not negligible with morbidity and mortality rates up to 25% and 16.7%, respectively (Talacchi et al, 1999). Acute postoperative complications were frequent, most notably a 22% incidence of temporary swallowing dysfunction.…”

Section: Choroid Plexus Papilloma (Cpp)mentioning

confidence: 99%