Choroid Plexus Papillary Carcinoma Associated with Hemorrhage

Guan, Jitian; Liu, GR; Guo, Gang; Geng, Yiqun; Cheng, Ying; Li, Yikai; Guo, YL

doi:10.1177/197140090601900510

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Lacking signs of impaired hemostasis, attention was initially focused on the tumor histotype, being choroid plexus tumors reportedly associated with intracranial hemorrhages even spontaneous and distant from the tumor site. [18][19][20][21][22] The third bleeding episode, which resembled hemorrhagic congestion of the choroid plexuses (Fig. 5), although calling for a search for hidden coagulopathies, reinforced the impression that the main problem could be a structural abnormality of the choroid plexus or a tumor-specific propensity for delayed bleeding, as also observed for other histotypes.…”

Section: Observationsmentioning

confidence: 73%

Factor XI deficiency and delayed hemorrhages after resection of choroid plexus papilloma: illustrative case

Mancarella

Marini

Severino

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUND Factor XI deficiency, also known as hemophilia C, is a rare inherited bleeding disorder that may leave routine coagulation parameters within normal range. Depending on the mutation subtype, prolonged activated partial thromboplastin time may occasionally be found. The disease has an autosomal transmission, with an estimated prevalence in the general population of approximately 1 in 1 million. Heterozygosis accounts for partial deficits, but the tendency to bleed is unrelated to the measured activity of factor XI. Diagnosis usually follows unexpected hemorrhages occurring spontaneously or after trauma or surgical procedures. OBSERVATIONS Few cases have been reported in the neurosurgical literature, all occurring spontaneously or after head trauma. Owing to its subtle features, the true incidence of the disease is probably underestimated. The authors report a case of a patient with previously undiagnosed factor XI deficiency who underwent uncomplicated resection of a fourth-ventricle papilloma and experienced delayed, severe hemorrhagic complications. LESSONS The known association between choroid plexus tumors and intracranial bleeding raised differential diagnosis issues. This report may serve to help to investigate delayed hemorrhages after cranial surgery.

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Section: Observationsmentioning

confidence: 73%

Factor XI deficiency and delayed hemorrhages after resection of choroid plexus papilloma: illustrative case

Mancarella

Marini

Severino

et al. 2021

Journal of Neurosurgery: Case Lessons

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Choroid plexus carcinoma of the spinal canal without cranial lesion

Bekiesińska‐Figatowska¹,

Mądzik²,

Biejat

et al. 2009

European Journal of Radiology Extra

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Primary adult choroid plexus carcinomas: a single-center experience with a systematic review

Zuo,

Mai,

Jiang

et al. 2023

Front. Oncol.

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ObjectivePrimary adult choroid plexus carcinomas (PACPCs) are extremely rare brain tumors. The existing literature primarily comprises case reports, which limits our understanding of this uncommon disease. This study aims to describe the clinical characteristics and prognosis of PACPCs, as well as to identify optimal treatment strategies.MethodsWe conducted a comprehensive analysis of clinical data from 7 patients with PACPCs who underwent surgical treatment at the Department of Neurosurgery, Beijing Tiantan Hospital, between March 2011 and March 2023. Additionally, a thorough search of the PubMed database was performed using the keywords “choroid plexus carcinoma” or “choroid plexus carcinomas” within the time frame of August 1975 to April 2023, which yielded a total of 28 identified cases. Subsequently, we evaluated risk factors for progression-free survival (PFS) and overall survival (OS) based on the pooled cases.ResultsThe pooled cohort, consisting of 7 cases from our institution and 28 cases from the literature, included 20 males and 15 females with a mean age of 44.3 ± 14.7 years (range: 21-73 years). Gross-total resection (GTR) and non-GTR were achieved in 22 (62.9%) and 13 (37.1%) patients, respectively. Radiotherapy and chemotherapy were administered to 29 (90.6%) and 13 (40.6%) patients, respectively. After a mean follow-up of 21.0 ± 26.7 months (range: 2-132 months), 18 patients were alive, and 11 patients had died. The multivariate Cox regression model demonstrated that non-GTR (HR 5.262, 95% CI 1.350-20.516, p=0.017) was a negative prognostic factor for OS. However, we did not find any risk factors for PFS.ConclusionComplete surgical resection should be considered as the primary treatment approach for this rare disease. Chemotherapy and radiotherapy appear to have limited effectiveness in treating this condition. Further research with large cohorts is needed to validate our conclusions.

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Choroid Plexus Papillary Carcinoma Associated with Hemorrhage

Cited by 3 publications

References 9 publications

Factor XI deficiency and delayed hemorrhages after resection of choroid plexus papilloma: illustrative case

Factor XI deficiency and delayed hemorrhages after resection of choroid plexus papilloma: illustrative case

Choroid plexus carcinoma of the spinal canal without cranial lesion

Primary adult choroid plexus carcinomas: a single-center experience with a systematic review

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