Choroid Plexus Metastasis From Papillary Thyroid Carcinoma Presenting With Intraventricular Hemorrhage

Wasita, Brian; Sakamoto, Makoto; Mizushima, Minoru; Kurosaki, Masamichi; Watanabe, Takashi

doi:10.1227/01.neu.0000369193.03305.00

Cited by 21 publications

(19 citation statements)

References 11 publications

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“…CPM lesions originating from thyroid carcinoma are extremely rare, with only five cases reported thus far (8)(9)(10)(11)(12). In this report, we described the sixth such case; all six cases are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 79%

“…Wasita et al reported that, in their case, the tumor was initially not recognized because it was obscured by the focal IVH. One month later, following blood reabsorption, the tumor was identified and removed (11). In our case, CT revealed the IVH, and we planned endoscopic hematoma evacuation, which ultimately could not be performed.…”

Section: Discussionmentioning

confidence: 85%

“…The rapid type is often fatal, causing death within a few years, while patients with the slow type may survive for more than 10 years. Interestingly, metastasis of RCC to the choroid plexus occurs most often in association with the slowly progressive type (11,29). Similarly, indolent DTC may have a higher tendency to metastasize to the choroid plexus during a slowly progressive disease course than in cases of lethal anaplastic thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The disease-specific mortality rate of DTC metastasis is 67%, with a median product-limit survival of 12.4 months (4-7). In addition, among types of brain metastasis cases, choroid plexus metastasis (CPM) is extremely rare, with only five cases reported in the literature to date (8)(9)(10)(11)(12). In this report, we describe the sixth case of FTC metastasizing to the choroid plexus in a patient presenting with intraventricular hemorrhage (IVH) 13 years after total thyroidectomy.…”

Section: Introductionmentioning

confidence: 97%

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Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage

et al. 2015

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Choroid plexus metastasis (CPM) is extremely rare and originates most frequently from renal cell carcinoma (RCC). We herein report the case of a 58-year-old man who developed a solitary CPM lesion derived from follicular thyroid carcinoma in addition to intraventricular hemorrhage. Computed tomography revealed acute hydrocephalus as a result of the hemorrhage, and we planned endoscopic hematoma evacuation. Since it was too difficult to reach the hematoma, we considered the possibility of a neoplasm and performed a biopsy of the lesion, the results of which led to an accurate diagnosis of CPM in this case. We also review previous reports of CPM originating from thyroid carcinoma compared with RCC.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage

et al. 2015

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“…Different treatment modalities, such as radioiodine therapy, external beam radiation and surgery have been suggested and used in the limited number of cases [8]. In the present case, surgery was chosen because of the nature of the tumor.…”

Section: A B Pamukkale Tıp Dergisi 2013;6(2):104-106mentioning

confidence: 99%

Calvarial metastasis from papillary thyroid carcinoma: A case report

Bozkurt¹,

Ozdemir²,

Percinel³

et al. 2013

Pau Med J

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A large variety of metastatic tumors can be found in the skull; breast, prostate, lung carcinoma, multiple myeloma, neuroblastoma and sarcoma are among those that have been reported in the literature. In the current case, a very rare case of metastasis to skull from papillary thyroid carcinoma is reported. A 45-year-old man was admitted to our service with head trauma. Computed tomography and magnetic resonance imaging revealed lytic mass lesions in the right frontal and occipital bone extending through the dura mater and subcutaneous tissue. Right frontal, suboccipital craniectomy, tumor excision were performed and microscopic examination revealed papillary thyroid carcinoma metastasis. There is no consensus on treatment protocols for patients with central nervous system metastases from papillary thyroid carcinoma, most likely because of the rarity of cases. In the present case, we suggest that the best option for treatment of papillary thyroid carcinoma metastasis to skull would be surgery followed by radiotherapy. Pam Med J 2013;6(2):104-106Key words: Brain tumors, Craniotomy, Metastasis, Papillary Thyroid Carcinoma ÖzetKranial bölgeye bir çok farklı tümör metastaz yapabilmektedir; bunlar içerisinde meme, prostat, akciğer kanseri, multipl myeloma, nöroblastoma ve sarkoma sayılabilir. Bu yazıda çok nadir görülen papiller tiroid karsinomunun kraninuma metastazı sunulacaktır. 45 yaşında erkek hasta kafa travması şikayeti ile kliniğimize başvurdu. Çekilen kranial tomografi ve magnetik rezonans incelemelerinde sağ frontal ve oksipital kemikte dura mater ve subkutanöz dokulara uzanım gösteren litik kitle lezyonları tespit edildi. Çok nadir görülmesi nedeni ile papiller tiroid karsinomunun santral sinir sistemi metastazının tedavisi ile ilgili literatürde net bir tedavi şeması bulunmamaktadır. Bu yazı ile papiller tiroid karsinomunun kranial metastazında en uygun tedavi yönteminin cerrahi rezeksiyon ve ardından radyoterapi uygulaması şeklinde olduğu belirtilmiştir.

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Clinicopathological and immunohistochemical study of 20 choroid plexus tumors: their histological diversity and the expression of markers useful for differentiation from metastatic cancer

et al. 2011

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The aim of this study was to summarize the clinicopathological features and the histological diversity of choroid plexus tumors and to examine the expression of immunohistochemical markers that are useful for their differentiation from metastatic cancer. Twenty cases were collected, including 11 choroid plexus papillomas, 5 choroid plexus adenomas, 1 atypical choroid plexus papilloma, and 3 choroid plexus carcinomas. The choroid plexus papillomas showed various parenchymal and stromal changes: focal solid growth, oncocytic alterations, melanin deposition, calcification, ossification, and xanthogranulomatous reactions. The choroid plexus tumors showed the following cytokeratin (CK) 7 and 20 staining patterns: CK7(+)/CK20(+) (11/19 cases), CK7(+)/CK20(-) (7/19 cases), CK7(-)/CK20(-) (1/19 cases), and CK7(-)/CK20(+) (0/19 cases). Positivity for CK5/6 and thyroid transcription factor-1 was found in 3 of 18 and 1 of 19 cases, respectively. All cases were negative for the estrogen receptor (0/18 cases). The choroid plexus tumors showed various CK7/CK20 staining patterns, and the staining of CK7 and CK20 in most CK7(+)/CK20(+) and CK7(+)/CK20(-) cases was focal, in contrast to that observed in carcinomas. Therefore, nondiffuse staining of CK, rather than the CK7/CK20 panel itself, is important for discriminating between a choroid plexus tumor and metastatic cancer.

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Choroid Plexus Metastasis From Papillary Thyroid Carcinoma Presenting With Intraventricular Hemorrhage

Abstract: Choroid plexus metastasis from papillary thyroid carcinoma is very rare, and this is the first case of intraventricular hemorrhage reported.

Cited by 21 publications

References 11 publications

Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage

Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage

Calvarial metastasis from papillary thyroid carcinoma: A case report

Clinicopathological and immunohistochemical study of 20 choroid plexus tumors: their histological diversity and the expression of markers useful for differentiation from metastatic cancer

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