Choroid Plexus Carcinomas and Rhabdoid Tumors: Phenotypic and Genotypic Overlap

Wyatt-Ashmead, Josephine; Kleinschmidt‐DeMasters, Bette K.; Mierau, Gary W.; Malkin, David; Orsini, Edmund N.; McGavran, Loris; Foreman, Nicholas

doi:10.1007/s10024001-0085-3

Cited by 30 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of necrosis has been considered as malignancy criteria (20,21). None of the cases in our series had notable necrosis, either on the MRI or under a microscope, which is consistent with the benign nature of CPPs.…”

Section: Discussionsupporting

confidence: 76%

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Shi

Chen

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were retrospectively observed. The mass site, size, contour, signal intensity, cystic or solid appearance, calcification, capsules, degree and pattern of enhancement, and hydrocephalus were evaluated based on CT or MRI. The misdiagnosis rate of CPPs in extraventricular sites was 80.0% (8/10). Solitary masses and multiple masses were observed in nine patients (90.0%, 9/10) and one patient (10%, 1/10), respectively. In addition to the typical imaging findings [a lobulated, cauliflower-like or mulberry-like mass that is homogeneous isointense or slightly hypointense on T1-weighted imaging (T1WI) and heterogeneous isointense or slightly hyperintense on T2WI], four masses had round or oval contours and three had cystic components; abnormal signal intensity (mixed hyperintense signals on T1WI and T2WI or slightly hyperintense signals on T1WI or hypo-/hyperintense on T2WI) and low or no enhancements were observed in three and six masses, respectively; absence of hydrocephalus and mild or local hydrocephalus were each observed in four subjects, respectively. Hemorrhage and psammomatous bodies and/or calcification were observed in four and three masses, respectively. In conclusion, in addition to the typical imaging findings, atypical imaging findings, including atypical contours, abnormal signal intensity, low enhancement and absence of hydrocephalus were also observed in extraventricular CPPs.

show abstract

Section: Discussionsupporting

confidence: 76%

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Shi

Chen

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Cases were classified according to the WHO nomenclature 26 as papilloma (PP) and carcinoma (CA). We further divided the carcinomas into well [WCA] or poorly differentiated [PCA], similarly to what was done by others 21,27 . Five cases of normal fetal choroid plexus (NFCP) (between 16 and 40 gestational weeks) were also studied to compare their immunohistochemical pattern with those of tumors.…”

Section: Methodsmentioning

confidence: 99%

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus

Barreto

Vassallo

Queiróz

2004

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Background: Choroid plexus tumors are rare. Results on immunohistochemical features are scanty and controversial even regarding normal plexus. Method: Thirteen cases of choroid plexus tumors and five samples of normal fetal choroid plexus were submitted to immunohistochemical study using a panel of epithelial, neuronal and stromal markers. Results/Conclusions: Relevant histological findings were presence of clear cells in 3/5 papillomas (PP) and 7/8 carcinomas (CA) and all 5 fetal plexuses; rhabdoid cells, desmoplasia and vascular proliferation were found respectively in 3, 4 and 5 cases out of 6 poorly differentiated CA and were absent in PP and well differentiated CA. Pancytokeratin AE1/AE3 was strongly positive in all 13 cases, even in the undifferentiated component of poorly differentiated CA, where reactivity was focal in 3 and diffuse in 3 cases. Low molecular weight cytokeratin (35βH11) was not expressed in any of the 8 CA, but was present in all 5 PP. In 4 of 6 poorly differentiated CA there was reactivity for smooth muscle actin (1A4) in 10 to 30% of the cells. This was true also for one case lacking rhabdoid cells. Laminin was undetectable in all 6 cases of poorly differentiated CA but was present in 4 PP and 2 well differentiated CA. All 5 fetal plexuses expressed GFAP.KEY WORDS: choroid plexus tumors, normal fetal choroid plexus, immunohistochemistry, central nervous system. Papilomas e carcinomas do plexo coróide: estudo histológico e imuno-histoquímico e comparação com plexo coróide fetal normal RESUMO -Contexto: Os tumores do plexo coróide são raros. Os resultados de dados imuno-histoquímicos são escassos e controversos, o mesmo valendo para o plexo coróide normal. Método: Treze casos de tumores do plexo coróide e cinco exemplares de plexo coróide fetal normal foram submetidos a estudo imuno-histoquímico, utilizando-se marcadores para antígenos epiteliais, neurais e estromais. Resultados/Conclusão: Os achados histológicos mais relevantes foram células claras em 3/5 papilomas (PP) e 7/8 carcinomas (CA) e em todos os 5 plexos fetais; células rabdóides, desmoplasia e proliferação vascular foram encontradas, respectivamente, em 3, 4 e 5 casos de 6 CA pouco diferenciados, mas não nos PP e CA bem diferenciados. A pancitoqueratina AE1/AE3 foi fortemente positiva em todos os 13 casos, mesmo no componente indiferenciado do CA pouco diferenciado, em que a reatividade foi focal em 3 casos e difusa em outros 3. A citoqueratina de baixo peso molecular (35βH11) não foi expressa em nenhum dos 8 CA, mas estava presente em todos os 5 PP. Em 4/6 CA pouco diferenciados houve reatividade para actina de músculo liso (1A4) em 10-30% das células. Este achado ocorreu também em um caso sem células rabdóides. Laminina não foi detectada em nenhum dos 6 CA pouco diferenciados, mas estava presente em 4 PP e em 2 CA bem diferenciados. Todos os 5 plexos fetais expressaram GFAP. PALAVRAS-CHAVE: tumores do plexo coróide, plexo coróide fetal normal, imuno-histoquímica, sistema nervoso central.

show abstract

“…22,24 However, glioblastoma cases have been described where the sarcomatous components show osteo-chondrogenic or rhabdoid differentiation. [25][26][27] In such cases, cytogenetic analysis demonstrated that both the glioblastoma and mesenchymal component share identical abnormalities, suggesting a common clonal origin. 25 In addition, recent studies have shown that a subclass of glioblastoma exhibits molecular and phenotypic mesenchymal features, raising the question about the cellular origin of these tumors.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal differentiation of glioblastoma stem cells

et al. 2008

View full text Add to dashboard Cite

Glioblastoma multiforme is a severe form of cancer most likely arising from the transformation of stem or progenitor cells resident in the brain. Although the tumorigenic population in glioblastoma is defined as composed by cancer stem cells (CSCs), the cellular target of the transformation hit remains to be identified. Glioma stem cells (SCs) are thought to have a differentiation potential restricted to the neural lineage. However, using orthotopic versus heterotopic xenograft models and in vitro differentiation assays, we found that a subset of glioblastomas contained CSCs with both neural and mesenchymal potential. Subcutaneous injection of CSCs or single CSC clones from two of seven patients produced tumor xenografts containing osteochondrogenic areas in the context of glioblastoma-like tumor lesions. Moreover, CSC clones from four of seven cases generated both neural and chondrogenic cells in vitro. Interestingly, mesenchymal differentiation of the tumor xenografts was associated with reduction of both growth rate and mitotic index. These findings suggest that in a subclass of glioblastomas the tumorigenic hit occurs on a multipotent stem cell, which may reveal its plasticity under specific environmental stimuli. The discovery of such biological properties might provide considerable information to the development of new therapeutic strategies aimed at forcing glioblastoma stem cell differentiation.

show abstract

Choroid Plexus Carcinomas and Rhabdoid Tumors: Phenotypic and Genotypic Overlap

Cited by 30 publications

References 10 publications

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus

Mesenchymal differentiation of glioblastoma stem cells

Contact Info

Product

Resources

About