Choroid plexus carcinoma with leptomeningeal spread in an adult: a case report and  review of the literature

Jo, In Young; Yeo, Seung‐Gu; Oh, Hyung Geun; Oh, Jae Sang

doi:10.1186/s13256-021-02887-2

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Overall, this adds to the growing body of literature regarding metastatic CPC and outcomes of surgical management. [26][27][28][29][30] The findings in this case raise the possibility that there may exist a subgroup of patients with histological evidence of CPC that cluster epigenetically with pediatric subgroup B but who lack evidence of TP53 mutation or polymorphisms associated with dysregulation of p53 in CPT. Further, this subgroup may have distinct outcomes with an individualized set of surgical management options.…”

Section: Lessonsmentioning

confidence: 77%

Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case

Guadix

Garman

Gundlach

et al. 2023

Journal of Neurosurgery: Case Lessons

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OBJECTIVE Choroid plexus carcinoma (CPC) is a rare, primarily intraventricular neoplasm. Extent of resection correlates with improved outcomes but is limited due to tumor vascularity and size. Evidence on optimal surgical management and molecular drivers of recurrence remains limited. Here the authors characterize a case of multiply recurrent CPC treated with sequential endoscopic removals over 10 years and highlight its genomic properties. OBSERVATIONS Five years after standard treatment, a 16-year-old female presented with a distant intraventricular recurrence of CPC. Whole exome sequencing revealed NF1, PER1, and SLC12A2 mutations, FGFR3 gain, and no TP53 alterations. Repeat sequencing on recurrences 4 and 5 years later showed persistent NF1 and FGFR3 alterations. Methylation profiling was consistent with plexus tumor, subclass pediatric B. Short-term magnetic resonance imaging detected four total isolated recurrences, all treated with complete endoscopic resections at 5, 6.5, 9, and 10 years after initial diagnosis. Mean hospital stay for all recurrences was 1 day with no complications. LESSONS The authors describe a patient with four isolated recurrences of CPC over a decade, each treated with complete endoscopic removal, and identify unique molecular alterations that persisted without TP53 alterations. These outcomes support frequent neuroimaging to facilitate endoscopic surgical removal following early detection of CPC recurrence.

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Section: Lessonsmentioning

confidence: 77%

Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case

Guadix

Garman

Gundlach

et al. 2023

Journal of Neurosurgery: Case Lessons

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“… 2 Nevertheless, CPCs tend to spread extensively along the ventricle into the spinal canal; thus, they are frequently associated with leptomeningeal seeding upon initial diagnosis. 4 , 7 The manifestation of CPCs in patients generally includes symptoms of increased intracranial pressure and hydrocephalus, alongside neurological symptoms linked to the mass effect of the lesion. 2 …”

Section: Discussionmentioning

confidence: 99%

Recurrent choroid plexus carcinoma treated with CyberKnife radiosurgery: illustrative case

Yuan,

Park,

Persad

et al. 2024

J Cosmet Laser Ther

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BACKGROUND Choroid plexus carcinomas (CPCs) are rare malignant brain tumors primarily affecting children younger than 2 years old. These tumors originate from the choroid plexus epithelium and are a subtype of choroid plexus tumors, which account for 1%–4% of pediatric brain tumors. Although CPCs often show a notably high recurrence rate after surgery, the standard treatment approach remains gross-total resection (GTR) of the tumor, given the lack of clinical data supporting the effectiveness of adjunct treatment options such as radiotherapy or chemotherapy. OBSERVATIONS A 16-year-old female with a history of a recurrent cranial CPC resistant to surgery and radiotherapy was treated with CyberKnife stereotactic radiosurgery (SRS), following resection. The procedures successfully maintained local disease control for 41 months; however, there was a subsequent recurrence, ultimately leading to the death of the patient. LESSONS CPC treatment remains challenging. SRS can be used as a viable adjunct to surgery, which remains the gold standard, although it can also be considered for nonsurgical candidates or when GTR cannot be achieved. Nevertheless, it is crucial to conduct additional research to explore diverse approaches for radiosurgery, including its role as the primary treatment modality versus its combination with surgery, radiotherapy, or chemotherapy. https://thejns.org/doi/10.3171/CASE23748

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Primary adult choroid plexus carcinomas: a single-center experience with a systematic review

Zuo,

Mai,

Jiang

et al. 2023

Front. Oncol.

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ObjectivePrimary adult choroid plexus carcinomas (PACPCs) are extremely rare brain tumors. The existing literature primarily comprises case reports, which limits our understanding of this uncommon disease. This study aims to describe the clinical characteristics and prognosis of PACPCs, as well as to identify optimal treatment strategies.MethodsWe conducted a comprehensive analysis of clinical data from 7 patients with PACPCs who underwent surgical treatment at the Department of Neurosurgery, Beijing Tiantan Hospital, between March 2011 and March 2023. Additionally, a thorough search of the PubMed database was performed using the keywords “choroid plexus carcinoma” or “choroid plexus carcinomas” within the time frame of August 1975 to April 2023, which yielded a total of 28 identified cases. Subsequently, we evaluated risk factors for progression-free survival (PFS) and overall survival (OS) based on the pooled cases.ResultsThe pooled cohort, consisting of 7 cases from our institution and 28 cases from the literature, included 20 males and 15 females with a mean age of 44.3 ± 14.7 years (range: 21-73 years). Gross-total resection (GTR) and non-GTR were achieved in 22 (62.9%) and 13 (37.1%) patients, respectively. Radiotherapy and chemotherapy were administered to 29 (90.6%) and 13 (40.6%) patients, respectively. After a mean follow-up of 21.0 ± 26.7 months (range: 2-132 months), 18 patients were alive, and 11 patients had died. The multivariate Cox regression model demonstrated that non-GTR (HR 5.262, 95% CI 1.350-20.516, p=0.017) was a negative prognostic factor for OS. However, we did not find any risk factors for PFS.ConclusionComplete surgical resection should be considered as the primary treatment approach for this rare disease. Chemotherapy and radiotherapy appear to have limited effectiveness in treating this condition. Further research with large cohorts is needed to validate our conclusions.

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Choroid plexus carcinoma with leptomeningeal spread in an adult: a case report and review of the literature

Cited by 4 publications

References 14 publications

Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case

Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case

Recurrent choroid plexus carcinoma treated with CyberKnife radiosurgery: illustrative case

Primary adult choroid plexus carcinomas: a single-center experience with a systematic review

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