Choriovitreal neovascularization following transpupillary thermotherapy for choroidal melanoma

Kıratlı, Hayyam; Bilgiç, Sevgül

doi:10.1038/sj.eye.6700369

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…If the burn involves the iris, then cataract can develop [ 28 ]. Excessive energy can cause retinal vascular occlusions with neovascular complications [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Phototherapy of Uveal Melanoma

Heimann

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Damato

2014

Clinical Ophthalmic Oncology

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“…If the burn involves the iris, then cataract can develop [ 28 ]. Excessive energy can cause retinal vascular occlusions with neovascular complications [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Phototherapy of Uveal Melanoma

Heimann

Seider

Damato

2014

Clinical Ophthalmic Oncology

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“…Note: n -number of patients, * -significance of differences. образование на ранних стадиях с целью проведения органосохранного лечения, которое включает лазерные и лучевые методы [4][5][6][7]. В последние годы в современной офтальмологии появился метод ОКТ-А [11], позволяющий неинвазивно определять основной патогномоничный признак опухоли -ее сосуды [12,13].…”

Section: Discussionunclassified

“…2021;18(1):96-102 ВВЕДЕНИЕ Меланома хориоидеи -злокачественная опухоль сосудистой оболочки глаза, являющаяся одной из самых частых внутриглазных новообразований, склонная к раннему метастазированию, достигающему даже на ранних стадиях 15 % [1][2][3]. При начальной меланоме хориоидеи применяют лазерное (разрушающая лазерная коагуляция, транспупиллярная термотерапия) и лучевое (брахитерапия) лечение [4][5][6][7].…”

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Optical Coherence Tomography — Angiography in Revealing Predictors of Small Choroidal Melanoma Transpupillary Thermotherapy Efficiency

2021

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Purpose. To reveal predictors of small choroidal melanoma transpupillary thermotherapy efficiency using optical coherence tomography-angiography.Patients and methods. 34 patients with small choroidal melanoma at an average age of 55.0 ± 2.9 years were examined. Optical coherence tomography-angiography was performed on an OCT-Angiography Software for RS-3000 Advance Optical Coherent Tomograph, Nidek, Japan, before and 4 months after 1 session of transpupillary thermotherapy. Transpupillary thermotherapy (TTT) was performed with a Nidec DC 3300 diode laser.Results. Prior to TTT — a loop-shaped, cranked-convoluted with an uneven lumen heterogeneous nature of the vasculature of the tumor with numerous bends and interlacing, located under the vessels of the retina in the central zone; the area of neovascular vasculature is 32.82 mm2, the density is 12.42 %. The limiting avascular zone is on the periphery. Around melanoma is a homogeneous hyperreflective rim of dilated choriocapillaries. 4 months after 1 session of TTT in 24 (70.6 %) of 34 cases — occlusion of the choriocapillaries in the central and peripheral zone of the tumor (avascular regions), expansion of the large and medium vessels of the choroid around the focus — predictors of complete tumor devitalization (chorioretinal scar). In 6 (17.6 %) of 34 patients, occlusion of the choriocapillaries in the central zone, expansion of large and medium vessels of the choroid around the tumor, along its periphery and in the paracentral region, retinochoroidal anastamoses along the periphery and in the paracentral zone, heterogeneous neovascularization of the choriocapillaries around; decrease in the area of vasculature — 12.44 mm2, density — 6.15 %, (p < 0.05) — predictors of partial devitalization of small choroidal melanoma (residual tumor). In 4 (11.8 %) of 34 cases, tumor vessels in the tumor area, large and medium vessels of the choroid around, along its periphery and in the central zone, occlusion of the choriocapillaries in the central zone, retinochoroidal anastamoses in the periphery and in the central zone, heterogeneous neovascularization choriocapillaries around; vascular network area — 29.13 mm2, density — 10.17 %, (p > 0.05), lack of devitalization (continued growth).Conclusion. The introduction of optical coherence tomography-angiography revealed the predictors of the effectiveness of transpupillary thermotherapy of the initial melanoma of the choroid, which are various types of tumor vascularization, indicating its about complete, partial or absence devitalization after treatment.

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“…Although sporadic cases have been reported, 1,2 CVNV often occurs as a result of iatrogenic damage to the retinal layers and Bruch's membrane from high-energy laser or cryotherapy 3 for treating various pathologies such as diabetic retinopathy, sickle cell disease, 4 retinal vein occlusions, 3 and tumors. 5 Prior reports of CVNV preceded the widespread use of anti-vascular endothelial growth factor (anti-VEGF) agents, and were associated with a poor prognosis.…”

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confidence: 99%