Chorioretinal Vascular Oxygen Tension Changes in Response to Light Flicker

Shakoor, Akbar; Blair, Norman P.; Mori, Marek; Shahidi, Mahnaz

doi:10.1167/iovs.06-0291

Cited by 39 publications

(47 citation statements)

References 25 publications

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“…Furthermore, the areas with the thinner choroid were found to be in the papillomacular region. This observation would comply with the hypothesis that retinal metabolism may play a role in the underlying choroidal physiology [7,8]. As studies have suggested an asymmetry in mitochondrial distribution and smaller ganglion cell axon size in the papillomacular region [9,10], a lesser retinal metabolic activity over the choroid might interfere with the choroidal vascular permeability [11] (thus potentially influencing the tissue's overall thickness).…”

Section: Discussionsupporting

confidence: 77%

Choroidal Thickness of the Papillomacular Region in Young Healthy Individuals

et al. 2014

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Purpose: To characterize the choroidal thickness of the papillomacular region in young healthy individuals using spectral-domain optical coherence tomography (SD-OCT). Methods: Papillary and macular SD-OCT scans were obtained using an enhanced depth imaging mode. Digital retinography was used to assess any overlapping areas and to determine the papillomacular region. Spearman's correlations were used to explore the relationship between the different regional choroidal thicknesses. Results: Sixty-three volunteers aged 21.6 ± 1.1 years were included. There was a significant asymmetry in choroidal thickness throughout the 10-mm length model (p < 0.001). While the choroid was shown to thicken as the distance from the optic disc increased (p < 0.001), each of the 500-µm blocks of the papillomacular region were significantly thinner than their nasal counterparts (p < 0.02 in all pairwise comparisons). Conclusion: In young healthy individuals, the choroid under the papillomacular region appears to be thinner than in other areas. These differences could relate to specificities of the retina overlying this region.

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Section: Discussionsupporting

confidence: 77%

Choroidal Thickness of the Papillomacular Region in Young Healthy Individuals

et al. 2014

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“…However, the light flicker induces measurable changes in retinal metabolism and blood flow [20], and the condition can be reproduced physiologically by moving the gaze over a visual field with many contrast borders. Furthermore, light flicker may reflect stimulus conditions during the watching of television and computer monitors.…”

Section: Discussionmentioning

confidence: 99%

Interaction between flicker-induced vasodilatation and pressure autoregulation in early retinopathy of Type 2 diabetes

Bek

Hajari

Jeppesen

2008

Graefes Arch Clin Exp Ophthalmol

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“…The cellular generators of the N1P1 waveform (mainly ON-and OFF-bipolar cells) are in part supplied by the choroid (Hayreh and Gartner, 1990) and the increased neural activity during time-slice stimulation may increase perfusion demands beyond that which can be supported by the choroid. Shakoor (2006) showed that flicker stimulation increases retinal blood flow but has no effect on choroidal blood flow. It was suggested that this was due to the poor autoregulation of the choroid as the flickering stimulus had a selective effect on inner retinal metabolic activity, but not outer retinal metabolic activity (Shakoor, 2006).…”

Section: Discussionmentioning

confidence: 99%