Chorionic gonadotropin as a modulator of cell interactions in the induction of a primary immune response

Kevorkov, N. N.; Shirshev, S. V.

doi:10.1007/bf01188737

Cited by 2 publications

(2 citation statements)

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“…In contrast to PGE 2, this type of PG activates lymphocyte function [1], which is evidently why injections of CG to intact female mice increase the production of antibody-producing ceils [3,5,6]. Voltaren, an inhibitor of PG synthesis, has been shown to suppress the formation of the adoptive immune response, whereas CG and estradiol cancel out this depression [5].…”

Section: Resultsmentioning

confidence: 99%

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Contribution of the reproductive hormones to the regulation of prostaglandin F2α production by immunocompetent cells

1995

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The ability of estradiol, progesterone, and chorionic gonadotropin to influence prostaglandin F2~ production by intact splenocytes of CBA mice was studied. Estradiol and progesterone similarly activated the processes of prostaglandin F2~ production. No relationship was revealed between the effect and the concentration of the hormones. Chorionic gonadotropin activated prostaglandin production by immunocompetent cells but only when used in a concentration reflecting the peak of its physiological secretion. Combining gonadotropin with estradiol or progesterone did not lead to any appreciable differences in the prostaglandin-stimulating action of each hormone alone.Key Words: prostaglandin F~; chorionic gonadotropin; estradiol; progesterone; splenocytes From the immunological viewpoint, pregnancy is still an enigma: a semiallogenic fetus, despite the functional intactness of the maternal lymphocytes, is not subject to immune aggression. Such reproductive hormones as chorionic gonadotropin (CG), estradiol, and progesterone, whose concentrations during pregnancy increase by several orders of magnitude, are known to exert strong immunomodulating effects [2,5,6]. It is possible that these very hormones create the basic prerequisites for normal development of the foreign fetus during gestation. However, the mechanisms of hormonal regulation of immunoeompetent cell functioning are not yet quite clear, nor are the results of their combined action.Prostaglandins (PG) are potent mediators of immunocompetent cells, and therefore the level of their production gives an idea of the functional activity of the immune system cells. The majority of studies of PG have been devoted mainly to PG class

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Section: Resultsmentioning

confidence: 99%

“…Such reproductive hormones as chorionic gonadotropin (CG), estradiol, and progesterone, whose concentrations during pregnancy increase by several orders of magnitude, are known to exert strong immunomodulating effects [2,5,6]. It is possible that these very hormones create the basic prerequisites for normal development of the foreign fetus during gestation.…”

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confidence: 99%