Chorionic Gonadotrophin in the Human Placenta in Relation to the Sex of the Foetus at Term

Hobson, B. M.; Wide, Leif

doi:10.1677/joe.0.0600075

Cited by 23 publications

(11 citation statements)

References 13 publications

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“…The results of the present investigation do agree with those previously published in which CG was found in term placentae from marmosets and rhesus monkeys [Hobson, 1972;Hobson and Wide, 1972]. The concentration of biologically active CG in ape and monkey placentae was, with the exception of the marmoset and lemur, within the range for human placentae at term [Hobson and Wide, 1974], The higher CG concentration in the placenta from one orang-utan, obtained early in pregnancy, is similar to that of man, where the highest concentrations of CG in placental tissue are also found early in gestation [Diczfalusy, 1953;Hobson, 1972]. In all the extracts from term pla centae the CG activity was higher in the bioassay.…”

Section: Discussionsupporting

confidence: 93%

The Similarity of Chorionic Gonadotrophin and Its Subunits in Term Placentae from Man, Apes, Old and New World Monkeys and a Prosimian

Hobson¹,

Wide²

1981

IJFP

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Chorionic gonadotrophin (CG) was estimated, by bioassay and radioimmunoassay (RIA), in placental extracts from 11 ape and monkey species. There was a significant correlation between the results of the two assay systems (r = 0.903, p < 0.001). The concentration of CG in most primate term placentae was the same as that in the human placenta at term. Extracts from all placentae cross-reacted with antiserum to ovine LH-β subunit, and those of the chimpanzee and gorilla also had a significant cross-reaction with an antiserum to the carboxyl terminal peptide of the HCG-β subunit. Primate placentae chromatographed on Sephadex G-200 had components active in the RIA systems for HCG, HCG-α HCG-β sub-units. In general, the elution profiles of all ape and monkey placental extracts resemble those made from human term placentae and of purified HCG and its subunits. The shape of the elution patterns from human and non-human material suggests that there was more than one molecular form of CG-α subunit activity. A second, more retarded molecular form having β subunit activity was found in extracts made from human, gorilla, gibbon and rhesus monkey placentae. The similarity between the structure of ape and monkey placental CG with HCG and its subunits implies a function similar to that of HCG in late pregnancy.

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Section: Discussionsupporting

confidence: 93%

The Similarity of Chorionic Gonadotrophin and Its Subunits in Term Placentae from Man, Apes, Old and New World Monkeys and a Prosimian

Hobson¹,

Wide²

1981

IJFP

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“…They have been com¬ pared with those of a previous investigation on term (37-41 weeks gestation) placentae (Hobson & Wide, 1974). The results of both investigations were converted to logarithmic values and their means and S.D.…”

Section: Resultsmentioning

confidence: 99%

“…It has been shown that the amount of human chorionic gonadotrophin (HCG) present in serum (Brody & Carlström, 1965), urine (Danielsson, 1965), serum and amniotic fluid (Crosignani, Nencioni & Brambati, 1972), and term placentae (Hobson & Wide, 1974) was related to the sex of the foetus. This relationship -significantly lower levels of HCG when the conceptus was male than when it was female -seems to be true for serum and urinary HCG in late pregnancy only.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between the Sex of the Foetus and the Amount of Human Chorionic Gonadotrophin in Placentae From the 10th to the 20th Week of Pregnancy

Wide¹,

Hobson²

1974

Journal of Endocrinology

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Sixty-seven placentae were obtained by abdominal hysterotomy, between the 10th and 20th weeks of pregnancy, from women who had had a therapeutic abortion. Human chorionic gonadotrophin (HCG) in extracts from these placentae was assayed by a biological and a radioimmunological method. When the concentration and total amount of HCG in placentae was related to the sex of the foetus no significant difference between 'male' and 'female' placentae was found. This is contrary to findings at term when there is a significant (P < 0\m=.\005) difference in the concentration of HCG/g and/placenta in 'male' and 'female' placentae. The amount of biologically active HCG in 'female' placentae significantly increased but was unchanged in 'male' placentae when the periods 10\p=n-\20 and 37\p=n-\41 weeks were compared. Similarly, the amount of immunologically active HCG in 'female' placentae was unchanged but in 'male' placentae it decreased. The possible reasons for the different results obtained with the biological and the radioimmunological assays are discussed.

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“…Since regulation of HCG secretion is incompletely understood -albeit androgens [39][40][41] and pros taglandins [42] might play a role -this question is difficult to answer. According to Belisle et al [29], HCG in serum is 4-to 5-fold below normal values in women who subsequently start to bleed.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Early Pregnancy HCG Determination as a Prognostic Tool for Fetal Outcome

Bremme

Eneroth²,

Nord³

1983

Gynecol Obstet Invest

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In a retrospective study of 150 pregnant women with high or low serum HCG levels at the time they sought acute advice at the ward, two categories of women were found: a majority (n = 111) who had abdominal pain and/or vaginal bleeding, and a minor group (n = 39) who worried about their condition but were otherwise symptom free. The underlying reason for the difference in clinical outcome amongst ‘bleeding’ and ‘concern’ women with both high and low HCG serum values are discussed. It is concluded that women with abnormal HCG levels in early pregnancy deserved close attention in the 3rd trimester.

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Chorionic Gonadotrophin in the Human Placenta in Relation to the Sex of the Foetus at Term

Cited by 23 publications

References 13 publications

The Similarity of Chorionic Gonadotrophin and Its Subunits in Term Placentae from Man, Apes, Old and New World Monkeys and a Prosimian

The Similarity of Chorionic Gonadotrophin and Its Subunits in Term Placentae from Man, Apes, Old and New World Monkeys and a Prosimian

Relationship Between the Sex of the Foetus and the Amount of Human Chorionic Gonadotrophin in Placentae From the 10th to the 20th Week of Pregnancy

An Evaluation of Early Pregnancy HCG Determination as a Prognostic Tool for Fetal Outcome

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