Chorionepithelioma in an 18-Year-Old Primigravida

Choriocarcinoma

“…Further examples are recorded by Cosgrove (1938), Rust (1938) andTrafford (1953). A second possibility is that the growth may be surrounded or damaged by haemorrhage which prevents the elaboration and absorption of gonadotrophin (Durburg, 1946). This would explain the occasional negative tests following a positive one as in the case of Tuchschmid (1943), and is comparable to the transient disappearance of gonadotrophin which may occur during a threatened abortion.…”

A Case of Chorionepithelioma of the Uterus With Pulmonary Metastases Cured by Operation and X‐rays

“…The Mount Vernon report on the slide, which was sent with the patient, was as follows: "The section shows blood clot, uterine muscle, and a malignant tumour composed mainly of chorionic processes; very little syncytial tissue been reported (Browne, 1930;Scott, 1939;Acosta-Sison and Espaniola, 1941 ;Durburg, 1946;Dilworth et al, 1950); (6) the cytotrophoblast composing the tumour may not show any of the recognized signs of malignancy such as anaplasia, hyperchromatosis, abnormal mitoses, etc. In this connexion it will be recalled that the normal cytotrophoblast of the early ovum possesses one character usually associated with malignancy, namely the power to erode maternal blood vessels and thus establish the maternal placental circulation.…”