Choriocarcinoma syndrome in a 24-year-old male

Arana, Santiago; Fielli, Mariano; González, Alejandra; Segovia, Jaime; Villaverde, Marcelo

doi:10.1258/shorts.2012.012004

Cited by 17 publications

(18 citation statements)

References 7 publications

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“…Typically choriocarcinoma syndrome occurs shortly after the administration of chemotherapy and is associated with a high mortality rate at an early phase of treatment induction [26]. Choriocarcinoma syndrome is not exclusively found in choriocarcinoma since it is also described in other cases of embryonal tumors or seminomas [27][28][29]. Additionally, our patient suffered from paraneoplastic hy- perthyroidism.…”

Section: Discussion/conclusionmentioning

confidence: 79%

Extracorporeal Membrane Oxygenation Support as a Bridge to Recovery during Chemotherapy in a Young Patient with Metastatic Choriocarcinoma and Severe Acute Respiratory Distress Syndrome

et al. 2020

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• Polychemotherapy in choriocarcinoma triggers acute respiratory distress syndrome (ARDS). • Choriocarcinoma is curable, but severe ARDS leads to death. Novel Insights • Extracorporeal membrane oxygenation (ECMO) support enables continuation of polychemotherapy in severe ARDS as a bridge to recovery. • ECMO support should not be excluded a priori for cancer patients and deserves consideration as a rescue therapy for patients with at least stable disease and eligible for full-code intensive care unit management. • An interdisciplinary strategy combining polychemotherapy and intensive care support including ECMO support may enable a curative approach also in patients with metastatic choriocarcinoma and ARDS.

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Section: Discussion/conclusionmentioning

confidence: 79%

Extracorporeal Membrane Oxygenation Support as a Bridge to Recovery during Chemotherapy in a Young Patient with Metastatic Choriocarcinoma and Severe Acute Respiratory Distress Syndrome

et al. 2020

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“…Elements include hemorrhagic sequela of metastatic disease in any organ system involved [3]. Choriocarcinomas are heavily vascular; therefore, they often present with life threatening hemorrhage from metastatic sites [4]. Lung metastasis leading to diffuse alveolar hemorrhage is the most common manifestation as seen in our patient; however, literature describes bleeding at other metastatic sites including the liver, kidneys, bone, small intestines, and brain.…”

Section: Discussionmentioning

confidence: 96%

Choriocarcinoma Syndrome: A Potentially Fatal Complication of Testicular Cancer

Zeitjian

Arslan

Borja-Alvarez

et al. 2019

Case Reports in Oncological Medicine

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Choriocarcinoma syndrome is a rare clinical entity with advanced, high volume choriocarcinomatous tumors and markedly elevated B-hCG (>50,000 IU/L). Recognition is important because the diagnosis of this syndrome identifies poor prognosis without mortality-proven management options. We present a case of a male in his twenties with metastatic choriocarcinoma who developed choriocarcinoma syndrome acutely after chemotherapy commencement. The patient deceased after hypoxic respiratory failure due to diffuse alveolar hemorrhage as a result of death of vascular tumors. While the prognosis for early diagnosis and treatment is excellent, the prognosis for late diagnosis is grim. Unfortunately, despite surgical or chemotherapeutic intervention, this syndrome has poor outcome.

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“…It has been reported that choriocarcinoma syndrome should be suspected in patients who exhibit high HCG levels, large tumors, and multiple metastases in the early stages of chemotherapy . ARDS due to bleeding from lung metastases has been well characterized, and there have also been reports about bleeding from liver and brain metastases…”

Section: Discussionmentioning

confidence: 99%

Case of acute respiratory distress syndrome in a patient with an extragonadal germ cell tumor without lung metastasis in which choriocarcinoma syndrome was suspected

et al. 2019

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Abbreviations & Acronyms ARDS = acute respiratory distress syndrome BEP = bleomycin etoposide cisplatin CT = computed tomography HCG = human chorionic gonadotropin TIP = paclitaxel ifosfamide cisplatin Correspondence: KotaIntroduction: Choriocarcinoma syndrome is caused by bleeding from metastatic germ cell tumors with choriocarcinoma components. Here, we report a case of acute respiratory distress syndrome, which arose after first-line chemotherapy for an extragonadal germ cell tumor without lung metastasis. Case presentation: A 41-year-old male visited our institution with chief complaints of back pain and weight loss. Computed tomography showed multiple lymph node metastases in the retroperitoneal cavity. There were no lung metastases. A lymph node biopsy resulted in a diagnosis of choriocarcinoma. Bleomycin etoposide cisplatin therapy was started as induction chemotherapy. On the first day, he was diagnosed with acute respiratory distress syndrome due to choriocarcinoma syndrome. We administered highdose hydrocortisone therapy for 3 days. The patient's respiratory status improved. Conclusion: In patients who are at high risk of developing choriocarcinoma syndrome, induction chemotherapy might lead to the development of acute respiratory distress syndrome due to the release of cytokines despite the absence of lung metastasis.

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Choriocarcinoma syndrome in a 24-year-old male

Cited by 17 publications

References 7 publications

Extracorporeal Membrane Oxygenation Support as a Bridge to Recovery during Chemotherapy in a Young Patient with Metastatic Choriocarcinoma and Severe Acute Respiratory Distress Syndrome

Extracorporeal Membrane Oxygenation Support as a Bridge to Recovery during Chemotherapy in a Young Patient with Metastatic Choriocarcinoma and Severe Acute Respiratory Distress Syndrome

Choriocarcinoma Syndrome: A Potentially Fatal Complication of Testicular Cancer

Case of acute respiratory distress syndrome in a patient with an extragonadal germ cell tumor without lung metastasis in which choriocarcinoma syndrome was suspected

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