Choriocarcinoma of the Esophagus Producing Chorionic Gonadotropin

Kikuchi, Yūko; Tsuneta, Yasuhiro; Kawai, Terukuni; Aizawa, Mamoru

doi:10.1111/j.1440-1827.1988.tb02322.x

Cited by 7 publications

(13 citation statements)

References 18 publications

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“…Primary tumors of the upper gastrointestinal tract showing hepatoid differentiation or trophoblastic differentiation are extremely rare. Most have been reported as arising in the stomach 11–14 and, to our knowledge, only seven have been documented in the esophagus 15–19 . Two reports suggested primary esophageal choriocarcinomas to have been derived from adenocarcinomas in BE 17,20 .…”

Section: Discussionmentioning

confidence: 96%

Hepatoid adenocarcinoma in Barrett’s esophagus associated with achalasia: First case report

Tanigawa

Kida

et al. 2002

Pathology International

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We report an unusual hepatoid adenocarcinoma in Barrett's esophagus with achalasia, which developed in a 44-year-old Japanese woman. The patient received an esophago-gastrectomy after diagnosis of the tumor and achalasia at the lower esophagus, 4 months before her death due to multiple metastatic tumors of the liver. The main granular tumor removed surgically was a hepatoid adenocarcinoma, mainly composed of clear cancer cells (alpha-1 antitrypsin, albumin and alpha-fetoprotein positive), with elements of choriocarcinoma and tubular adenocarcinoma. Non-neoplastic specialized columnar epithelium was present extensively near the oral side of the tumor edge in the esophagus, indicating Barrett's esophagus. This unusual tumor was therefore considered to have originated in Barrett's esophagus. The gastroesophageal reflux was presumed to have occurred for a long period, as there was a well-preserved fundic gland in the stomach and a history of frequent vomiting from the patient's youth, accounting for the appearance of achalasia.

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Section: Discussionmentioning

confidence: 96%

Hepatoid adenocarcinoma in Barrett’s esophagus associated with achalasia: First case report

Tanigawa

Kida

et al. 2002

Pathology International

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“…Absence of a tumor in possible primary sites for choriocarcinoma, such as the mediastinum, retroperitoneum, stomach, jejunum and gallbladder, 20 and the presence of choriocarcinoma in the esophagus, contiguous with the overlying squamous cell carcinoma, suggested that the esophagus was the site of primary choriocarcinoma in this case. Primary esophageal choriocarcinomas are extremely rare and only six examples could be identified in the English literature 2–7 . Their ages ranged from 40 to 80 years, with a mean of 54.8 years.…”

Section: Discussionmentioning

confidence: 99%

Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: An autopsy case report

Ishihara

Mori²,

Koono

2002

Pathology International

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Esophageal squamous cell carcinoma in situ (SCCIS) with diffuse pagetoid features is a recently recognized rare variant of squamous cell carcinoma. A histopathological study of a specimen from a 70-year-old male Japanese patient is reported. The patient died of respiratory failure due to rapidly progressing metastatic pulmonary tumors of unknown origin 73 days after the onset of hemosputum. Autopsy disclosed widespread metastasis of choriocarcinoma in the absence of tumors of the testes or other common sites of germ cell tumors. Elevation of human chorionic gonadotropin (hCG-beta) levels was later detected in the stored serum. Serial histological evaluation of the entire esophagus revealed a small primary site of choriocarcinoma in a background of diffuse SCCIS, mainly of pagetoid type, accompanied by several small foci of submucosally invasive squamous cell carcinoma and primary mucoepidermoid carcinoma. These stimulated nodal metastasis independently of the choriocarcinoma. The SCCIS did not alter the gross mucosal appearance. This is the first reported case of diffuse pagetoid SCCIS combined with choriocarcinoma. Morphological findings and previous studies suggest that the extensive SCCIS of the esophagus resulted from pagetoid spread of tumor cells. The invasive squamous cell carcinoma, mucoepidermoid carcinoma and choriocarcinoma are suggested to have originated from the overlying SCCIS.

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“…Most have been reported as arising in the stomach [5,6,11,15]. To the best of our knowledge, only five choriocarcinomas have been documented as arising in the oesophagus [7,10,16,17,191, but primary hepatoid adenocarcinoma of the oesophagus has not been reported. Primary small cell carcinomas are known to arise in either the stomach or the oesophagus, although they are also rare [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors suggest that primary oesophageal choriocarcinomas arise in an adenocarcinoma in Barrett's oesophagus [10,19]. Two of the previously reported cases of primary oesophageal choriocarcinoma were the pure type [7,17]. In such pure cases, the common adenocarcinomatous components may have been expelled by the more aggressive choriocarcinomatous components.…”

Section: Discussionmentioning

confidence: 99%

Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus

Motoyama

Higuchi

Taguchi

1995

Vichows Archiv A Pathol Anat

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We describe an oesophageal tumour composed of choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma. The choriocarcinomatous areas and hepatoid adenocarcinomatous areas contained beta human chorionic gonadotropin-positive cells and alpha fetoprotein-positive cells, respectively. The small cell carcinomatous areas contained cells positive for serotonin or adrenocorticotrophic hormone, while the tubular adenocarcinomatous areas contained cells positive for carcinoembryonic antigen. Non-neoplastic gastric type columnar epithelium was found directly adjoing the tumour at the oral side. This tumour, with its unprecedented histology combination of tissues may have originated in Barrett's oesophagus, although we could not confirm a history of chronic gastro-oesophageal reflux.

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Choriocarcinoma of the Esophagus Producing Chorionic Gonadotropin

Cited by 7 publications

References 18 publications

Hepatoid adenocarcinoma in Barrett’s esophagus associated with achalasia: First case report

Hepatoid adenocarcinoma in Barrett’s esophagus associated with achalasia: First case report

Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: An autopsy case report

Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus

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