Choriocarcinoma Metastatic to Skin

Scalp Metastases Mimicking Alopecia Areata

“…While choriocarcinoma is well recognized for its frankly malignant behavior and high rate of metastases, PSTT also has been found in about 10–15% of cases to result in disseminated metastases, often with fatal outcome 1 . Cutaneous metastases from trophoblastic neoplasms are reported to occur only rarely, and it is even more rare for the cutaneous metastases to be the presenting manifestation 2,3 . We now report the first case of PSTT to initially present with cutaneous metastases.…”

Non‐hematopoietic cutaneous metastases in children and adolescents: thirty years experience at St. Jude Children's Research Hospital

“…Choriocarcinoma is only rarely reported to metastasize to the skin. 25 Osteosarcoma is the most common second malignancy in pediatric oncology patients and may arise in irradiated or unirradiated bone. 26 We identified two cases of metastasis (cases 23; Fig.…”

Choriocarcinoma of the Testis Metastatic to the Skin

“…Choriocarcinoma has a distinct propensity to spread hematogenously and the principal sites of involvement include lung, liver, intestines, spleen, adrenals, and brain 9 . Reports of metastatic choriocarcinoma infrequently mention the skin as a site of metastasis 6,7,12–15 . Reingold 12 reported 32 necropsied cases with cutaneous metastases from internal carcinoma.…”

“…An additional report 14 described a woman who developed multiple skin metastases following a miscarriage, but this report did not have histopathologic confirmation. Cosnow et al 15 reported a case in which a diagnosis of metastatic choriocarcinoma was made by the biopsy of a solitary nodule on the scalp of an asymptomatic woman, because both cytotrophoblastic and syncytiotrophoblastic elements were found in the cutaneous biopsy. The patient died and at autopsy metastatic choriocarcinoma was found in the brain, lungs, liver, kidneys, spleen, jejunum, and lymph nodes, but careful histologic examination failed to locate the primary site of the choriocarcinoma.…”