Choriocarcinoma Cells Modulate the Cytokine Production of Decidual Large Granular Lymphocytes in Coculture

Rieger, Lorenz; Kämmerer, Ulrike; Hofmann, Jürgen; Sütterlin, Marc; Dietl, Johannes

doi:10.1111/j.8755-8920.2001.460204.x

Cited by 26 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Uterine NK cells are a rich source of many different cytokines and growth factors including TNF-α, IL-10, GM-CSF, IL-1β, TGF-β1, CSF-1, LIF and IFN-γ (Saito et al, 1993;Jokhi et al, 1994;Jokhi et al, 1997;Rieger et al, 2001). In general investigation of cytokine production has been on uNK cells purified from early pregnancy decidua, with no separation of decidua basalis and decidua parietalis, although Von Rango et al (2003) compared cytokine production by uNK cells from decidua basalis and decidua parietalis and noted differences in cytokine profile.…”

Section: Functional Investigationsmentioning

confidence: 99%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

312

280

View full text Add to dashboard Cite

Section: Functional Investigationsmentioning

confidence: 99%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

312

280

View full text Add to dashboard Cite

“…Cytokine secretion of TNF-α, TGF-β1, IFN-γ, IL-8 and IL6 by uNK cells significantly increased in the present study following ULBP1 binding. Human uNK cells produce a variety of cytokines and growth factors, including TNF-α, IL-10, granulocyte-macrophage colony-stimulating factor, IL-1, TGF-β1, colony-stimulating factor-1, leukemia inhibitory factor, IFN-γ (45–47), IL-6 (9), IL-8 and interferon-inducible protein-10 (8), and the roles that these cytokines and growth factors have in EVT invasion has been investigated in previous studies. A study by Bauer et al (26) demonstrated that TNF-α inhibits trophoblast invasion through the elevation of plasminogen activator inhibitor-1.…”

Section: Discussionmentioning

confidence: 99%

Upregulated unique long 16 binding protein 1 detected in preeclamptic placenta affects human extravillous trophoblast cell line (HTR-8/SVneo) invasion by modulating the function of uterine natural killer cells

Liu

Song

Lin

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Well-controlled trophoblast invasion at the maternal-fetal interface is crucial for normal placentation and successful pregnancy, otherwise pathological conditions of pregnancy occur, such as preeclampsia. In previous studies, it has been demonstrated that unique long 16 binding protein (ULBP)1, a ligand for the natural-killer group (NKG)2D receptor on uterine natural killer (uNK) cells, is upregulated in the placenta in patients with preeclampsia. As they are present on the majority of the decidua, uNK have an important role in pregnancy. The aim of the present study was to determine the role of ULBP1 in trophoblast cell invasion, which is closely associated with the occurrence of preeclampsia. In the present study, ULBP1 expression levels in placentas collected after cesarean section from women with preeclampsia and normal pregnant women were determined by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. The effects of ULBP1 on extravillous trophoblast cell line (HTR-8/SVneo) invasion mediated via uNK cells and the underlying mechanisms were investigated. mRNA and protein expression levels of ULBP1 were significantly upregulated (P<0.05) in preeclamptic placentas compared with normal controls. ULBP1 inhibited HTR-8/SVneo cells via the regulation of biological functions of uNK cells, including the downregulation of NKG2D expression on uNK cells and the stimulation of production of cytokines and chemokines that affect extravillous cytotrophoblast invasion by uNK cells. ULBP1 may have an important role in the pathophysiology of preeclampsia through the modification of biological functions of uNK cells, which may affect trophoblast invasion.

show abstract

“…However, their levels diminish drastically toward the end of gestation (Williams et al 2009;Bulmer et al 2010). uNK are a rich source of a range of cytokines and angiogenic growth factors (Jokhi et al 1994(Jokhi et al , 1997Li et al 2001;Rieger et al 2001;Hanna et al 2006;Lash et al 2006aLash et al , 2010a.…”

Section: Immune Tolerancementioning

confidence: 99%

Molecular Cross-Talk at the Feto–Maternal Interface

Lash

2015

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

Molecular cross-talk at the feto-maternal interface occurs between many different cell types, including uterine leukocytes, extravillous trophoblast cells, and uterine spiral arteries, is essential for the establishment and maintenance of pregnancy. This review concentrates on human pregnancy and examines three main areas in which cross-talk occurs; immune tolerance, regulation of extravillous trophoblast invasion, and remodeling of the uterine spiral arteries.

show abstract

Choriocarcinoma Cells Modulate the Cytokine Production of Decidual Large Granular Lymphocytes in Coculture

Abstract: MHC class I positive/negative CC modulate the cytokine production of decidual LGL in different ways.

Cited by 26 publications

References 0 publications

Immune cells in the placental bed

Immune cells in the placental bed

Upregulated unique long 16 binding protein 1 detected in preeclamptic placenta affects human extravillous trophoblast cell line (HTR-8/SVneo) invasion by modulating the function of uterine natural killer cells

Molecular Cross-Talk at the Feto–Maternal Interface

Contact Info

Product

Resources

About