Choriocapillaris photodynamic therapy using indocyanine green

Costa, R. A.; Farah, Michel Eid; Freymüller, Edna; Morales, Paulo Henrique; Smith, Ricardo Luiz; Cardillo, J.A.

doi:10.1016/s0002-9394(01)01138-2

Cited by 64 publications

(39 citation statements)

References 24 publications

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“…In an uncontrolled clinical trial, occult choroidal neovascularization in age-related macular degeneration was selectively closed using 1.5 mg/kg of ICG at 3 W/cm 2 for 95 s (calculated as 285 J/ cm 2 ) [34] . In in vivo experiments the choriocapillaris of normal rabbits was closed successfully using PDT mediated by higher ICG doses (10-20 mg/kg) and an 810-nm diode laser at a fluence of 6.3 J/cm 2 [35] . Since choriocapillaris occlusion was always associated with some degree of RPE damage in this and in other studies [36,37] , the authors hypothesized that the RPE damage could be related to choroidal ischemia.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Ku70/80, Clusterin/ApoJ Isoforms and Bax Expression in Indocyanine-Green-Mediated Photo-Oxidative Cell Damage

Ricci¹,

Pucci²,

Sesti³

et al. 2007

Ophthalmic Res

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dium azide, suggesting the involvement of reactive oxygen species in the laser-induced cell damage. Bax was strongly induced after 4 and up to 24 h of treatment. The nuclear proapoptotic isoform of clusterin/ApoJ was selectively upregulated after 24 h of treatment. The DNA repair machinery was upregulated after 4 and up to 24 h. Conclusion: These data elucidate some molecular mechanisms involved in cell death induced by ICG photosensitization. The increase and relocalization of Bax into the mitochondria and the upregulation and translocation of the proapoptotic isoform of clusterin/ ApoJ in the nucleus demonstrated the involvement of these proteins in the photo-oxidative cell death pathway. These data point out new molecular targets and suggest potential applications in the therapy of the retinal diseases that could benefit by selective RPE treatment.

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Section: Discussionmentioning

confidence: 99%

Modulation of Ku70/80, Clusterin/ApoJ Isoforms and Bax Expression in Indocyanine-Green-Mediated Photo-Oxidative Cell Damage

Ricci¹,

Pucci²,

Sesti³

et al. 2007

Ophthalmic Res

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“…Oral corticosteroids were prescribed and by 2 weeks, the BCVA had further decreased to 20/125 þ 2 caused by a subretinal haemorrhage involving the macular region and increase in retinal oedema. ICG-mediated photothrombosis is a modality of laserdye treatment that uses large-spot, low-intensity 810-nm light to apply laser energy continuously to an area where ICG has been highly concentrated, 4 used recently in the management of CNV associated with age-related macular degeneration. 5 The study protocol was approved by the local institutional review board and a written informed consent was obtained before treatment.…”

Section: Case Reportmentioning

confidence: 99%

Indocyanine green-mediated photothrombosis combined with intravitreal triamcinolone for the treatment of choroidal neovascularization in serpiginous choroiditis

Navajas

Costa

Farah

et al. 2003

Eye

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Purpose To report a case of peripapillary choroidal neovascularization (CNV) complicating serpiginous choroiditis that was treated by a single indocyanine green (ICG)-mediated photothrombosis session combined to intravitreous triamcinolone acetonide (TA) injection. Methods Interventional case report. A 48-year-old patient with peripapillary CNV was submitted to a laser-dye-mediated technique that uses ICG and low-intensity 810-nm light for continuous laser application; TA was then injected into the vitreous cavity 1 hour later, and prospective evaluation with fluorescein and ICG angiography as well as optical coherence tomography (OCT) was performed. Results At 2 weeks after treatment, bestcorrected visual acuity improved from 20/200 to 20/50, with further improvement to 20/20À1 in the subsequent 10 weeks. Absence of fluorescein leakage from the CNV and OCT evidence of resolved retinal oedema was observed at that time. Clinical stabilization was maintained up to 1 year of follow-up. There was no significant complication related to the procedure. Conclusion Combined ICG-mediated photothrombosis and intravitreous TA induced rapid and significant visual acuity recovery in this particular case of peripapillary CNV complicating serpiginous choroiditis. Accordingly, angiographic and OCT findings demonstrated neovascular lesion regression and restoration of the macular architecture.

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“…Os fotossensibilizantes mais recentes foram desenvolvidos para superar essas dificuldades. Entre eles está a verteporfirina (36) e a indocianina verde (42) .…”

Section: Terapia Fotodinâmicaunclassified

“…Efeitos coroidais mais intensos foram observados com doses mais elevadas de luz. Exame clínico e retinografias de fundo não revelaram mudança na coloração retiniana após a TFD, embora um leve esbranquecimento retiniano tenha sido observado no dia seguinte (42) .…”

Section: B) Indocianina Verdeunclassified