Chorioangiomas – new insights into a well-known problem II. An immuno-histochemical investigation of 136 cases

Guschmann, M.; Henrich, Wolfgang; Dudenhausen, Joachim W.

doi:10.1515/jpm.2003.023

Cited by 44 publications

(44 citation statements)

References 10 publications

(21 reference statements)

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“…Large or giant chorioangiomas are often defined as a diameter of detected mass greater than 4 or 5 cm and have an incidence varying from 1:500 to 1:16,000 placentas examined. It is easier to detect larger chorioangiomas prenatally by USG and/or doppler imaging or on routine pathologic examination [2,3]. In our case, chorioangioma diagnosis was initially done by USG and doppler at the 24th week of gestation.…”

Section: Discussionmentioning

confidence: 95%

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A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review

Beyazıt¹,

Göret²,

Pek³

et al. 2016

Med-Science

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Chorioangioma, or hemangioma of the placenta, is the most frequent non-trophoblastic tumor of the placenta consisting of blood vessels and stroma. A great proportion of these tumors are small and well delineated within the placental parenchyma and have no or minimal adverse impact on the fetus. Unfortunately, large tumor size is linked to serious complications such as fetal anemia, hydrops and intrauterine death. This is probably because of arteriovenous shunts leading to progressive heart failure of the fetus. With the increasing rates of antenatal screenings with ultrasonography, prenatal diagnosis of these tumors is widely achieved. Here we report a case of giant placental chorioangioma diagnosed in the second trimester of pregnancy. The size of the tumor minimally increased during follow-up and at term, uncomplicated labor was achieved. Macroscopic and histologic examination confirmed the diagnosis.

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Section: Discussionmentioning

confidence: 95%

“…Although they can be detected in 0.6-1% of placentas with pathomorphological analysis, clinically evident chorioangiomas are rarely seen, with an incidence varying from 1:500 to 1:16,000 placentas examined [2,3]. Usually seen as a single tumor, some of them can present as multiple tumors.…”

Section: Introductionmentioning

confidence: 99%

A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review

Beyazıt¹,

Göret²,

Pek³

et al. 2016

Med-Science

View full text Add to dashboard Cite

show abstract

“…Only fifty percent are detected during prenatal period. 5 Moreover, its incidence rises with maternal age and is more prevalent in multiple gestation. Also, there are more female babies with angiomas in their placenta.…”

Section: Pathogenesis and Pathologymentioning

confidence: 99%

“…Also, there are more female babies with angiomas in their placenta. 5 Chorioangioma is thought to arise by day16 of fertilization, although there is no documentation of tumor in first trimester. HPE is consistent with a benign angioma arising from chorionic tissue.…”

Section: Pathogenesis and Pathologymentioning

confidence: 99%

Giant chorioangioma of placenta: an infrequent placental cause for adverse feto-maternal outcome

Marwah

Bansal

Gaikwad

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…Histologically they appear as a group of grossly enlarged intermediate and terminal villi that are not demarcated by a fibrous capsule but are simply surrounded by otherwise normal villous tissue [1] . CA occur in 0.6-1% of pregnancies at term [2] . Mainly they are isolated, microscopically small and without clinical significance.…”

Section: Introductionmentioning

confidence: 99%

The Changes in Angiogenic Gene Expression in Recurrent Multiple Chorioangiomas

Gallot

Marceau²,

Laurichesse‐Delmas³

et al. 2006

Fetal Diagn Ther

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Objectives: To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas. Methods: Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis. Results: Eleven genes presented more than two-fold alteration in expression levels: undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor β receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-α V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin). Conclusions: We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.

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Chorioangiomas – new insights into a well-known problem II. An immuno-histochemical investigation of 136 cases

Abstract: According to this study and the current literature in the field of hamartomas and some neoplasia, we can assume that increased growth factor expression plays a role in the formation of chorioangiomas, since it stimulates proliferation in a wide variety of cell compartments.

Cited by 44 publications

References 10 publications

A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review

A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review

Giant chorioangioma of placenta: an infrequent placental cause for adverse feto-maternal outcome

The Changes in Angiogenic Gene Expression in Recurrent Multiple Chorioangiomas

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