Chorioamnionitis exposure dampens the preterm monocyte response to subsequent challenges

Bermick, Jennifer; Schaller, Matthew

doi:10.1111/imcb.12174

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…On the other hand, most studies of early life LPS result in dampening of innate immunity in monocytes in offspring from LPS-treated dams compared with offspring from control pregnancies, suggesting an impaired capacity to respond to infection. In infants born to mothers with chorioamnionitis, for example, monocytes have impaired production of inflammatory cytokines and lower expression of genes involved in antigen presentation and adaptive immunity [ 165 , 166 ]. Taken together, altered microbiomes can have a profound effect both on the proper development and maintenance of immunity during critical periods of fetal development.…”

Section: Maternal Obesity Influences the Fetal Microbiome And Immune ...mentioning

confidence: 99%

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

Nelson,

Friedman

2024

IJMS

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Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with obesity have reduced immune responses to stimuli which increase susceptibility to infections. Recently, maternal western-style diets (WSDs), high in fat and simple sugars, have been associated with skewing neonatal immune cell development, and recent evidence suggests that dysregulation of innate immunity in early life has long-term consequences on metabolic diseases and behavioral disorders in later life. Several factors contribute to abnormal innate immune tolerance or trained immunity, including changes in gut microbiota, metabolites, and epigenetic modifications. Critical knowledge gaps remain regarding the mechanisms whereby these factors impact fetal and postnatal immune cell development, especially in precursor stem cells in bone marrow and fetal liver. Components of the maternal microbiota that are transferred from mothers consuming a WSD to their offspring are understudied and identifying cause and effect on neonatal innate and adaptive immune development needs to be refined. Tools including single-cell RNA-sequencing, epigenetic analysis, and spatial location of specific immune cells in liver and bone marrow are critical for understanding immune system programming. Considering the vital role immune function plays in offspring health, it will be important to understand how maternal diets can control developmental programming of innate and adaptive immunity.

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Section: Maternal Obesity Influences the Fetal Microbiome And Immune ...mentioning

confidence: 99%

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

Nelson,

Friedman

2024

IJMS

View full text Add to dashboard Cite

show abstract

Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection

Lewis,

Weitkamp,

Levy

2025

Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant

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Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19

Gilley,

Boly,

Paden

et al. 2023

Pediatr Res

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Chorioamnionitis exposure dampens the preterm monocyte response to subsequent challenges

Abstract: See also: Original Article by de Jong et al.

Cited by 3 publications

References 11 publications

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection

Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19

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