Chordoma of the atlas.

Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine

“…Only one of 15 patients treated for sphenoid or vertebral chordoma at Memorial Hospital survived without evidence of disease, s However, an occasional patient will survive a long time following biopsy and conventional radiation treatmenP or without treatment. 12 The failure rate for treatment of chondrosarcomas and osteogenic sarcomas of the cervical spine, the base of the skull region, or the calvaria is almost 100%. Local control has been achieved without complication in all 10 patients reported here, with follow-up periods of up to 6 years.…”

Transnasal Endoscopic Biopsy Approach to Atlas Tumor with X‐ray Assisted and Related Radiographic Measure

“…The atlas is located at the craniovertebral junction (CVJ); adjacent organs include the spinal cord, C 1 nerve, vertebral artery and pharynx. Chordomas, osteoblastomas and Ewing sarcomas are the commonest tumors that occur in in the anterior tubercle and anterior arch of the atlas, which may also be affected by rheumatoid arthritis and other inflammatory conditions. Atlas tumors reportedly have little morbidity.…”

Proliferative Potentials of Intracranial Chordomas with a Reference to Extracranial Chordomas.

“…Many investigators reported the difficulty of predicting distant metastasis on the basis of histological findings [4,9,18,25,35,36], although Chambers and Schwinn suggested a relationship between the metastasis and anaplastic histological features such as pleomorphism and hyperchromatism [5], which are known to be common in chordomas [5,10,26,30]. Many studies suggested the proliferative potentials of neoplasms to be essential for evaluating their biological features [8, 14, 19-22, 24, 29], and thus, the proliferative potentials of chordomas should be elucidated with reference to the clinical course including tumor recurrence.…”