Chordoma in Early Childhood: A Clinicopathological Study

Kaneko, Yasunari; Sato, Yuji; Iwaki, Toru; Shin, Ryong-Woon; Tateishi, J; Fukui, Masashi

doi:10.1227/00006123-199109000-00019

Cited by 54 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Today, however, immunohistochemical studies permit differentiation between the two lesions. 20,27 Furthermore, the chondroid type is more often observed in young patients 2,7,8,11,16,35 and a better prognosis generally exists for younger patients as well. 10,17,35 According to Forsyth, et al, 10 age less than 40 years is the only significant factor associated with better prognosis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Suboccipital and cervical chordomas: radical resection with vertebral artery control

Carpentier¹,

Blanquet²,

George³

2001

FOC

View full text Add to dashboard Cite

Object Radical resection of chordomas seems to improve a patient's long-term prognosis. At the suboccipital and cervical levels, the vertebral artery (VA) is often considered as a limit in surgical possibilities. The authors report on the management of the VA in a series of 36 patients with chordomas located in the cervical region. Methods Over an 11-year period, 36 patients with chordomas located at the suboccipital (28 patients) or cervical (eight patients) level were treated in the authors' neurosurgical department. In 30 patients, the tumors extended laterally toward the VA and required surgical control of the VA. Sixteen of these 30 patients harbored primary tumor, whereas 14 were treated for recurrent disease. The VA was encased in the tumor in 23 patients, with stenosis in six cases. A balloon occlusion test was performed in seven patients and the VA was resected in four. Extensive resection, via a lateral approach on one (22 cases) or on both (eight cases) sides, did not cause any permanent postoperative deficits. In five patients a complementary approach was performed: posterolateral in one and transoral in four. Spinal fixation was performed via the lateral approach (eight cases) or via a complementary posterior approach (five cases). All but two patients underwent radiotherapy, including 10 who underwent proton-beam radiotherapy. Conclusions Chordomas extending laterally to the VA can be radically resected via a lateral approach without causing significant morbidity. A complementary approach is often necessary. The best results are achieved in patients with primary compared with recurrent tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Alternatively it seems that very young patients (Ͻ 5 years of age) have a very poor prognosis. 20,35 Tumor recurrence and death very often occur in less than 1 year, and there is a high frequency of metastasis. Sex has also been proposed as a prognosis factor 4 but this has not been confirmed.…”

Section: Discussionmentioning

confidence: 99%

Suboccipital and cervical chordomas: radical resection with vertebral artery control

Carpentier¹,

Blanquet²,

George³

2001

FOC

View full text Add to dashboard Cite

show abstract

“…Distant metastases are mainly pulmonary. 31,37 This pattern has been correlated with a higher proportion of atypical pathological variants compared with adults especially those <5 years of age (approx 65% vs. 20%). This age group is also remarkable for a higher proportion of SC sites (25% vs. 6%), compared with older children.…”

Section: Review Of Literaturementioning

confidence: 96%

“…Metastases are more common in the course of the disease with a pediatric predominance compared with adults: 9-58% range vs. 7-40%. 10,31,37 In these situations, they are frequently associated with a local failure. 38 Some patterns of such "combined" failures are more frequently reported such as local + nodal or local + surgical route.…”

Section: Review Of Literaturementioning

confidence: 99%

“…<5 years of age) behave actually less favorably. 10,11,31,37,54 This seems to be related with a higher rate of undifferentiated histologies, and a more rapid pace of the disease, related with upfront or secondary metastases. These tumors are also more frequently located in the SC region with frequent advanced presentation that pose highly challenging surgical decisions (especially in case of S3 invasion).…”

Section: Review Of Literaturementioning

confidence: 99%

See 1 more Smart Citation

Reprint of “Chordoma in children: Case-report and review of literature”

Habrand

Datchary

Bolle

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

Sarcoma Protontherapy Children a b s t r a c tWe report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon-proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology.© 2015 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o. All rights reserved. IntroductionChordomas ( with the brachyury gene, a gene involved in the notochord development. 5,6 In the adults, they are located typically in the sacrococcygeal (SC) (50%), the intra cranial (IC), at the skull base (SB) (35%), and the intermediate spinal (S) regions (15%). Only 5% of cases have been described in the pediatric age, with unclear specificities concerning presentation, and outcome. We report in this paper a clinical case of skull base CH http://dx

show abstract

Metastatic skull base chordoma: A systematic review

Young

Nielsen

Bulosan

et al. 2022

Laryngoscope Investig Oto

View full text Add to dashboard Cite

Objective/Hypothesis To investigate the clinical features, management strategies and outcomes for patients with metastatic primary skull base chordomas. Study Design Systematic review. Methods A systematic search through Pubmed/Medline, Web of Science, and EBSCOhost (CINAHL) was conducted without restriction on dates. After study screening and full‐text assessment, two authors independently extracted all data using a pre‐established abstraction form. Results Forty cases were included from 38 studies. The average age (standard deviation [SD]) of the sample at presentation was 28.5 (23.3) and was equally distributed across genders. The average time (SD) between initial diagnosis to local recurrence was 40.1 (60.3) months. The average time (SD) from primary tumor detection to the diagnosis of metastatic disease was 55.2 (49.0) months. The most common subsite for metastatic spread were the lungs (32.5%). Of the 33 patients with data on outcomes, 48.5% were found to have expired by the time of publication. The median overall survival was estimated to be 84 months (95% confidence interval [CI] 62.3–105.7). Conclusions The most common subsites for metastatic spread of skull base chordoma were the lungs and bone. Overall survival for patients in the current cohort was a median of 84 months, with no significant differences noted when stratifying by the extent of surgery or the site of metastases. Level of Evidence 3a

show abstract

Chordoma in Early Childhood: A Clinicopathological Study

Cited by 54 publications

References 0 publications

Suboccipital and cervical chordomas: radical resection with vertebral artery control

Suboccipital and cervical chordomas: radical resection with vertebral artery control

Reprint of “Chordoma in children: Case-report and review of literature”

Metastatic skull base chordoma: A systematic review

Contact Info

Product

Resources

About