Chordoma and its embryonic determinants

Vanderheijden, Cas

doi:10.26481/marble.2014.v2.308

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2018

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“…A recent study showed that, other than Brachyury, another embryonic transcription factor like Twist might have a role in the tumorigenesis of chordoma (Vanderheijden, 2014). Therefore, we conducted the present study to investigate the possible role of Twist in cell migration of chordoma cells and its role in metastasis.…”

Section: Introductionmentioning

confidence: 95%

The effect of TWIST silencing in metastatic chordoma cells

et al. 2018

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Chordoma is a slowly growing and invasive bone tumor with a tendency to metastasize locally in advanced stages. It is essential to discover new therapeutics that target genes involved in the metastasis of chordoma. Epithelial-mesenchymal transition (EMT) might robustly influence the metastasis of a tumor bulk. To our knowledge, this is the first time to show that EMT might have a role in chordoma metastasis. In this study, we aim to investigate the possible role of Twist, a key player transcription factor of EMT, in chordoma metastasis. The TWIST gene was silenced by short hairpins in chordoma cell line MUG-Chor1 and effects on metastasis were investigated by wound healing/gap closure and invasion assays. Twist-silenced MUG-Chor1 cells were found to be less migratory and less invasive when compared to the negative control. This study indicates that Twist might have a role in metastatic chordoma cells.

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Section: Introductionmentioning

confidence: 95%