Chordoid Meningioma, an uncommon variant of meningioma: A clinicopathologic study of 12 cases

Epari, Sridhar; Sharma, Mehar Chand; Sarkar, Chitra; Garg, Ajay; Gupta, Anand; Mehta, Veer Singh

doi:10.1007/s11060-005-9092-y

Cited by 67 publications

(86 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A little more than 100 cases of chordoid meningioma have been described in the English-language literature, the majority of which are in the pathology and neurosurgery literature. [4][5][6][7][8][9] Attempts to distinguish benign from atypical and malignant meningiomas have been undertaken with variable results, and DWI and ADC values have provided the most reliable means of differentiation, 10,11 though no data analysis specifically examining the chordoid morphologic variant has been performed. To the best of our knowledge, only 3 case reports in which the MR imaging characteristics of chordoid meningiomas were described have been published in the radiology literature.…”

Section: Resultsmentioning

confidence: 99%

Chordoid Meningioma: Differentiating a Rare World Health Organization Grade II Tumor from Other Meningioma Histologic Subtypes Using MRI

Pond

Morgan²,

Hatanpaa³

et al. 2015

American Journal of Neuroradiology

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:Meningiomas are very commonly diagnosed intracranial primary neoplasms, of which the chordoid subtype is seldom encountered. Our aim was to retrospectively review preoperative MR imaging of intracranial chordoid meningiomas, a rare WHO grade II variant, in an effort to determine if there exist distinguishing MR imaging characteristics that can aid in differentiating this atypical variety from other meningioma subtypes.

show abstract

Section: Resultsmentioning

confidence: 99%

Chordoid Meningioma: Differentiating a Rare World Health Organization Grade II Tumor from Other Meningioma Histologic Subtypes Using MRI

Pond

Morgan²,

Hatanpaa³

et al. 2015

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

“…In our study we found an association between the presence of mast cells and brain oedema, especially in high grade group, however, there was no statistically significant correlation between both parameters because of low number of examined cases. Epari et al [12] and Tena-Suck et al [13] observed a significant number of mast cells and B lymphocytes in chordoid meningioma, in the stroma of connective tissue. Similar to our results were obtained by Bo et al [14] who observed a statistically significant association between the number of macrophages and mast cells and microscopic features of aggressiveness, i.e.…”

Section: Discussionmentioning

confidence: 97%

Mast cells evaluation in meningioma of various grades

Reszeć¹,

Hermanowicz

Kochanowicz

et al. 2012

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Abstract:Meningioma is a heterogenous group of primary brain tumors. The progression or recurrence is relatively very common; however, prognostic factors which may indicate those events are not known. The aim of the study was to evaluate the presence of mast cells within the low grade and high grade meningiomas. The material included 70 cases of meningomas (63 G1 grade cases) of adult subjects (range 23-84 years). In paraffin sections presence of tryptase, a marker of mast cells, was detected by immunohistochemistry in 10 random fields in each slide under the light microscope. The presence of the peritumoral oedema was estimated by brain computer tomography. The expression of tryptase was observed in 32% of low grade meningiomas and 86% of high grade meningiomas. The immunostained cells were observed close to the blood vessels. We conclude that the number of mast cells might be a significant prognostic factor for the recurrence or bad prognosis of meningiomas.

show abstract

“…In the event of subtotally resected intracranial CMs, post-operative radiotherapy is the standard treatment (10,14). Due to the aggressive growth pattern of spinal CMs and long-term fatal outcome in the present patient, post-operative early adjuvant radiotherapy and close follow-up investigation in adult and pediatric patients is recommended, although certain studies debate the benefit of post-operative adjuvant treatments in pediatric patients (2,7,15).…”

Section: Discussionmentioning

confidence: 99%

Spinal chordoid meningioma in a child: A case report and review of the literature

Yang

Fang

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

Abstract.As an uncommon subtype of meningioma, chordoid meningioma (CM) of the spinal canal is extremely rare. There have been only two reported cases of intraspinal CM in the literature, and this lesion has not been previously reported in the pediatric age group. To the best of our knowledge, the present study reports the first case of spinal chordoid meningioma in a pediatric patient. A 12-year-old female presented with a 3-month history of progressive numbness and weakness in the right-side limbs, and intermittent pain in the neck and right shoulder. Spinal magnetic resonance imaging (MRI) revealed an intraspinal lesion at the C2-3 level with irregularly heterogeneous enhancement. The patient underwent a C2-3 laminotomy. Due to adhesion to the dura and proximity to the vertebral artery, the tumor was partially removed intraoperatively. The post-operative course was uneventful and the symptoms were apparently relieved. The patient experienced recurrence 5 years subsequent to surgery. MRI revealed an extradural regrown tumor at the C2-5 level. Partial removal combined with radiotherapy was performed. However, the patient experienced progression of tetraplegia and succumbed to severe pneumonia and respiratory failure 5 months subsequent to the second surgery. In the present study, the clinicoradiological findings and treatment outcome of this rare entity are discussed, in addition to a review of the relevant literature. Spinal CMs should be included in the differential diagnosis of intraspinal tumors of the pediatric spine. Multidisciplinary treatment, consisting of total surgical removal and adjuvant radiotherapy, should be considered due to the aggressive nature of this abnormality and the risk of long-term recurrence.

show abstract

Chordoid Meningioma, an uncommon variant of meningioma: A clinicopathologic study of 12 cases

Cited by 67 publications

References 24 publications

Chordoid Meningioma: Differentiating a Rare World Health Organization Grade II Tumor from Other Meningioma Histologic Subtypes Using MRI

Chordoid Meningioma: Differentiating a Rare World Health Organization Grade II Tumor from Other Meningioma Histologic Subtypes Using MRI

Mast cells evaluation in meningioma of various grades

Spinal chordoid meningioma in a child: A case report and review of the literature

Contact Info

Product

Resources

About