Chordoid glioma: report of two rare examples with unusual features

Jain, Deepali; Sharma, Mehar Chand; Sarkar, Chitra; Suri, Vaishali; Rishi, Arvind; Garg, Ajay; Vaishya, Sandeep

doi:10.1007/s00701-008-1420-x

Cited by 30 publications

(48 citation statements)

References 17 publications

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“…Evidence of ependymal histogenesis was provided by the ultrastructural demonstration of microvilli-like structures and hemidesmosomes in these tumors [11]. These findings were confirmed in other studies [12]. A possible origin of the CG in tanycytic cells, specialized ependymal cells, with abundant cytoplasmic intermediate filaments, a basal lamina, and secretory granules has been proposed [3] but the absence of intercellular junctions argues against this hypothesis [13].…”

Section: Gc Has Recently Been Included (2000) In the Cns Tumormentioning

confidence: 62%

CD99 is expressed in chordoid glioma and suggests ependymal origin

2011

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Section: Gc Has Recently Been Included (2000) In the Cns Tumormentioning

confidence: 62%

CD99 is expressed in chordoid glioma and suggests ependymal origin

2011

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“…24,30) Other fatal complications were pneumonia, bacterial meningitis, septicemia, and cardiac arrest. 17,21,24,38) Nonfatal but serious morbidity was often found after surgical removal. 18,26,39) Diabetes insipidus, 3,14,34) hypotension and hyponatremia, 21,25) hypothermic episodes, 39) weight gain, 28) and memory disturbance and psychotic changes 3,16,26,28,31) were reported.…”

Section: Discussionmentioning

confidence: 99%

“…20) The ideal treatment for chordoid glioma would be GTR without complications, but this is quite difficult because of the size and location of the tumor. 8,13,17,27,31) PR can reduce the tumor volume and also increase the distance from the optic pathways, where the risk of morbidity could be minimized while the effect of gamma knife radiosurgery is maximized. Less invasive microsurgery and gamma knife radiosurgery with a lower marginal dose can provide a safe and effective treatment for chordoid glioma of the third ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,4,6,11,15,17,18,21,24,25,[27][28][29][30][32][33][34]36) Immunohistochemically, chordoid glioma is strongly and diffusely positive for GFAP and vimentin, and shows focal reactivity to EMA and cytokeratin in some cases, but little or no reactivity to S-100 protein. Some authors reported immunoreactivity for CD34, 4,12,15,17,18,21,24,25,27,28,30,31,[33][34][35][36] which will be useful for making differential diagnoses from chordoid meningioma, pilocytic astrocytoma, and/or ependymoma. 21) The MIB-1 index has been low in all reported cases, ranging from 0% to 5%.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Kobayashi

Tsugawa

Hashizume

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Chordoid glioma of the third ventricle is considered to be a benign glial tumor located exclusively in the mid-anterior portion of the third ventricle near the hypothalamus and optic nerves, with the histological features of a chordoma and immuno-labeling for glial fibrillary acidic protein. Unfortunately, the clinical outcome of chordoid glioma has been poor, even in patients receiving gross total or partial removal with or without radiotherapy. Three cases of chordoid glioma of the third ventricle were treated with less invasive microsurgery for pathological diagnosis or partial removal without neuro-endocrinological complication, followed by gamma knife radiosurgery using a lower marginal dose for the optic nerves and hypothalamus. Gamma knife radiosurgery was performed after open biopsy in two patients, and after partial removal in the third patient using a lower marginal dose of 10.5 to 12 Gy. Serial magnetic resonance imaging revealed gradual decrease or at least no change in the tumor size, without significant complication at follow up 70 and 66 months later in two cases. The third patient accidentally died 13 months after gamma knife treatment. We conclude that low dose gamma knife radiosurgery after less invasive microsurgery is both safe and effective for the control of chordoid glioma of the third ventricle over a very long follow-up period.

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“…From then on, approximately 50 cases of chordoid glioma, to our best knowledge, have been reported [1][2][3][4][5]7,8,[11][12][13][14][15][16][17][18][20][21][22][23]25,28) . Chordoid glioma is a rare lowgrade tumor of the brain, most of which are known to be located in the third ventricle, frequently attached to the hypothalamic or suprasellar area.…”

Section: Introductionmentioning

confidence: 99%

Chordoid Glioma : A Case Report of Unusual Location and Neuroradiological Characteristics

Kim

Choe

et al. 2010

J Korean Neurosurg Soc

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J Korean Neurosurg Soc 48 : [62][63][64][65] 2010 Since the World Health Organization (WHO) classification for central nervous system neoplasms was declared in 2000, chordoid glioma of the third ventricle has been noted as a newly recognized tumor for central nervous system neoplasms. Although there is not enough universal experience to know the nature of this tumor due to its rarity, the origin of chordoid glioma was guardedly proposed to be the ependymal cells of the third ventricle. Such an idea has been primarily based on the specific location of the tumor, that is, third ventricle, suprasellae, and hypothalamus. However, we report a rare case of histologically confirmed chordoid glioma located in the left thalamus, not attached to any of the midline structures having unusual neuroradiological characteristics. KEY WORDS :Chordoid glioma˙ Third ventricle˙ Radiological feature.

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Chordoid glioma: report of two rare examples with unusual features

Cited by 30 publications

References 17 publications

CD99 is expressed in chordoid glioma and suggests ependymal origin

CD99 is expressed in chordoid glioma and suggests ependymal origin

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Chordoid Glioma : A Case Report of Unusual Location and Neuroradiological Characteristics

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