Chordoid glioma of the third ventricle attached to the optic chiasm

Carrasco, Rodrigo; Pascual, José M.; Reina, Teresa; Nieto, Santiago; Linera, Juan Alvarez; Sola, Rafael G.

doi:10.1016/j.clineuro.2008.05.009

Cited by 18 publications

(8 citation statements)

References 30 publications

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“…[17, 25, 31] Less frequently, cystic components were noted on imaging in 9 patients. [4, 6, 10, 17, 23, 25, 31–36]…”

Section: Resultsmentioning

confidence: 99%

“…[13, 19, 26] Of the remaining cases, extent of infiltration was highly variable, ranging from occasional [27, 41] to prominent infiltration. [4, 10, 42, 43] Distribution of tumor infiltrating lymphocytes was also highly variable, with peripheral [21], scattered [30], and focal appearance. [44] Mitoses were consistently low [7, 10, 24, 33, 45–48] or absent [35] when noted.…”

Section: Resultsmentioning

confidence: 99%

“…The most common surgical approaches described to resect CG include transcallosal in 7 [12, 29, 37, 43, 44, 50], transcortical in 5 [22, 31, 51, 52], and trans-lamina terminalis in 17 [4, 11, 13, 17, 20, 23, 42, 43, 46, 47, 53–55]. Surgical approach was not specified in 52 patients.…”

Section: Resultsmentioning

confidence: 99%

“…[3] Histologically, CG are comprised of clusters and cords of epithelial cells in a mucinous matrix background with a strong presence of GFAP staining on immunohistochemistry. [4]…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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Introduction Chordoid Gliomas (CG) are rare neoplasms which frequently arise within the third ventricle. Surgery remains the mainstay treatment for CG. The present study comprehensively reviews all reported cases of CG within the literature in order to identify risk factors for surgical complications and tumor recurrence. Methods A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science was conducted following PRISMA guidelines to identify all reported cases of CG. Results A total of 81 patients met the study criteria, comprised of 33 males and 48 females. Median age at diagnosis was 48 years with a range from 5 to 72 years, and mean tumor size was 3.1 cm. Biopsy, subtotal resection (STR), and gross total resection (GTR) was achieved in 8, 34, and 33 patients, respectively, with 6 cases not reporting extent of eresection (EOR). Thirteen patients underwent adjuvant radiotherapy. Postoperative complications were noted in 30 cases (37%), with new onset diabetes insipidus being the most common. Postoperative morbidity was not associated with age, tumor size, or extent of resection. A trans-lamina terminalis approach demonstrated a strong trend towards decreased overall rates of postoperative morbidity compared to other approaches (p=0.051). GTR was associated with improved progression-free survival (PFS; p=0.028), while adjuvant radiotherapy, age, tumor size and MIB-I were not predictive of patient outcomes. Conclusion GTR should be the primary goal for the management of CG, as it is associated with improved rates of tumor control without an increased rate of postoperative complications. Surgical approach was a stronger predictor of complication rates than extent of resection. Morbidity remains high, and future studies to further elaborate on factors predictive of postoperative complications are critical.

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“…[17, 25, 31] Less frequently, cystic components were noted on imaging in 9 patients. [4, 6, 10, 17, 23, 25, 31–36]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…[3] Histologically, CG are comprised of clusters and cords of epithelial cells in a mucinous matrix background with a strong presence of GFAP staining on immunohistochemistry. [4]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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“…Third ventricular chordoid glioma, first described by Brat et al in 1998, is characterized by its stereotypic location in the anterior third ventricle and its chordoid cellular architecture composed of glial fibrillary acidic protein (GFAP)-positive tumor cells embedded within a myxoid matrix [1][2][3]. Due to their intraventricular location and large size, they often obstruct cerebrospinal fluid (CSF) flow and compress adjacent structures, leading to symptoms associated with obstructive hydrocephalus, such as intracranial hypertension, headache, nausea, vomiting, ataxia, but also visual impairment, mental status changes, memory deficits, and fatigue.…”

Section: Introductionmentioning

confidence: 99%

Chordoid glioma of the third ventricle: report of a rapidly progressive case

et al. 2017

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Chordoid gliomas are slowly growing third ventricular tumors that can be challenging to manage clinically. Rapid progression causing death has not been previously reported for this tumor type. We present and discuss a case of chordoid glioma that arose in a 46-year-old female who presented with progressive fatigue, headache, and altered mental status, attributable to severe hydrocephalus caused by a third ventricular mass. She underwent urgent subtotal resection and ventriculo-peritoneal shunt placements. Post-operative MRI noted residual tumor in the anterior resection cavity. An MRI performed 9 weeks later showed substantial progression, with marked tumor enlargement and compression of adjacent hypothalamic structures and the optic chiasm. Despite a course of radiation therapy, the tumor continued to enlarge, and the patient died from tumor progression 7 months after initial presentation. Post-mortem exam demonstrated a mass that expanded the third ventricle and compressed adjacent hypothalamic, thalamic and suprasellar structures. Histologic and immunohistochemical studies confirmed a chordoid glioma and revealed multifocal coagulative necrosis and intravascular thrombosis, which are unusual in this tumor type. Cytogenomic microarray testing revealed numerous DNA copy number abnormalities, many of which had not previously been reported in this tumor. The pathologic and cytogenetic changes may correlate with the aggressive behavior of this chordoid glioma and can be pursued by future investigation of additional cases.

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Benign Glioma

Filley

Miller

et al. 2023

Advances in Experimental Medicine and Biology

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Chordoid glioma of the third ventricle attached to the optic chiasm

Cited by 18 publications

References 30 publications

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Chordoid glioma of the third ventricle: report of a rapidly progressive case

Benign Glioma

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