Chordoid Glioma of the Third Ventricle: CT and MR Findings

Tonami, Hisao; Kamehiro, M; Oguchi, Manabu; Higashi, Kentaro; Yamamoto, Ikuo; Njima, Tadao; Okamoto, Kouichirou; Akai, Takuya; Iizuka, Hiroshi

doi:10.1097/00004728-200003000-00029

Cited by 35 publications

(30 citation statements)

References 10 publications

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“…The characteristic MR imaging findings are an isointense ovoid or round mass on T 1 -weighted and a slightly hyperintense mass on T 2 -weighted images, with homogeneous enhancement by gadolinium. 29,37) Most tumors are solid, but some cystic area is present in 25% of cases. CT will be helpful for detecting any abnormal calcification present.…”

Section: Discussionmentioning

confidence: 99%

“…Conventional radiotherapy was given in 4 cases, 3,14,37) and two died of recurrence. Two patients survived for 4 years and for 9 months, one of whom received focal radiotherapy of 52 Gy with additional stereotactic radiosurgery of 20 Gy.…”

Section: Discussionmentioning

confidence: 99%

“…Two patients survived for 4 years and for 9 months, one of whom received focal radiotherapy of 52 Gy with additional stereotactic radiosurgery of 20 Gy. 37) Two patients underwent additional interstitial radiotherapy to the residual tumor. 21) One patient survived for 15 months but the other died after 11 months from recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Another case of PR was followed by focal radiotherapy of 52 Gy with additional stereotactic radiosurgery of 20 Gy to the residual tumor. 37) No information was available on the outcome of the patient after such a high-dose treatment.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Kobayashi

Tsugawa

Hashizume

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Chordoid glioma of the third ventricle is considered to be a benign glial tumor located exclusively in the mid-anterior portion of the third ventricle near the hypothalamus and optic nerves, with the histological features of a chordoma and immuno-labeling for glial fibrillary acidic protein. Unfortunately, the clinical outcome of chordoid glioma has been poor, even in patients receiving gross total or partial removal with or without radiotherapy. Three cases of chordoid glioma of the third ventricle were treated with less invasive microsurgery for pathological diagnosis or partial removal without neuro-endocrinological complication, followed by gamma knife radiosurgery using a lower marginal dose for the optic nerves and hypothalamus. Gamma knife radiosurgery was performed after open biopsy in two patients, and after partial removal in the third patient using a lower marginal dose of 10.5 to 12 Gy. Serial magnetic resonance imaging revealed gradual decrease or at least no change in the tumor size, without significant complication at follow up 70 and 66 months later in two cases. The third patient accidentally died 13 months after gamma knife treatment. We conclude that low dose gamma knife radiosurgery after less invasive microsurgery is both safe and effective for the control of chordoid glioma of the third ventricle over a very long follow-up period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Kobayashi

Tsugawa

Hashizume

et al. 2013

Neurol. Med. Chir.(Tokyo)

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“…Post-mortem exam demonstrated a mass that expanded the third ventricle and compressed adjacent hypothalamic, thalamic and suprasellar structures. Histologic and immunohistochemical studies confirmed a chordoid glioma and revealed multifocal coagulative necrosis and intravascular insipidus, obesity, other endocrinological disorders, as well as amnesia [5][6][7][8][9]. Subtotal resection is often accompanied by tumor recurrence, typically after numerous years.…”

Section: Introductionmentioning

confidence: 99%

Chordoid glioma of the third ventricle: report of a rapidly progressive case

et al. 2017

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Chordoid gliomas are slowly growing third ventricular tumors that can be challenging to manage clinically. Rapid progression causing death has not been previously reported for this tumor type. We present and discuss a case of chordoid glioma that arose in a 46-year-old female who presented with progressive fatigue, headache, and altered mental status, attributable to severe hydrocephalus caused by a third ventricular mass. She underwent urgent subtotal resection and ventriculo-peritoneal shunt placements. Post-operative MRI noted residual tumor in the anterior resection cavity. An MRI performed 9 weeks later showed substantial progression, with marked tumor enlargement and compression of adjacent hypothalamic structures and the optic chiasm. Despite a course of radiation therapy, the tumor continued to enlarge, and the patient died from tumor progression 7 months after initial presentation. Post-mortem exam demonstrated a mass that expanded the third ventricle and compressed adjacent hypothalamic, thalamic and suprasellar structures. Histologic and immunohistochemical studies confirmed a chordoid glioma and revealed multifocal coagulative necrosis and intravascular thrombosis, which are unusual in this tumor type. Cytogenomic microarray testing revealed numerous DNA copy number abnormalities, many of which had not previously been reported in this tumor. The pathologic and cytogenetic changes may correlate with the aggressive behavior of this chordoid glioma and can be pursued by future investigation of additional cases.

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Management of Rare Central Nervous System Tumors

Hsu

Sawaya

2003

Combined Modality Therapy of Central Nervous System Tumors

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Chordoid Glioma of the Third Ventricle: CT and MR Findings

Cited by 35 publications

References 10 publications

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

Chordoid glioma of the third ventricle: report of a rapidly progressive case

Management of Rare Central Nervous System Tumors

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